Beilstein J. Nanotechnol.2025,16, 371–384, doi:10.3762/bjnano.16.28
mucoadhesive drug delivery system that was developed to fulfill these requirements. Alginate nanoparticles were synthesized by water-in-oil emulsification followed by external gelation and then coated with the mucoadhesive polymer EudragitRS100. The formulated nanoparticles had a mean size of 219 nm and
developed in this study is intended to be loaded with active therapeutic agents and has the potential to be used as an alternative drug delivery strategy for the treatment of gastric related diseases.
Keywords: alginate; EudragitRS100; mucoadhesive nanoparticles; mucus; smart drug delivery; Introduction
of the mucoid surface [17]. EudragitRS100 polymer has been used for several applications aimed at different sites of the body such as skin [18], intestinal [16], intranasal [19], or ocular [20] drug delivery. This broad range of application sites is possible because pH-independent swelling of the
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Figure 1:
Micrographs of nanoparticles. SEM micrographs of (A) Alg NPs and (B) EudAlg NPs. STEM micrographs o...