Development of a mucoadhesive drug delivery system and its interaction with gastric cells

• Ahmet Baki Sahin,
• Serdar Karakurt and
• Deniz Sezlev Bilecen

Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28

• mucoadhesive drug delivery system that was developed to fulfill these requirements. Alginate nanoparticles were synthesized by water-in-oil emulsification followed by external gelation and then coated with the mucoadhesive polymer Eudragit RS100. The formulated nanoparticles had a mean size of 219 nm and

• developed in this study is intended to be loaded with active therapeutic agents and has the potential to be used as an alternative drug delivery strategy for the treatment of gastric related diseases. Keywords: alginate; Eudragit RS100; mucoadhesive nanoparticles; mucus; smart drug delivery; Introduction

• of the mucoid surface [17]. Eudragit RS100 polymer has been used for several applications aimed at different sites of the body such as skin [18], intestinal [16], intranasal [19], or ocular [20] drug delivery. This broad range of application sites is possible because pH-independent swelling of the