Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

• Thi Ngoc Han Pham,
• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan Thang Cao,
• Thanh-Danh Nguyen,
• Vy Tran Anh and
• Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

• and diagnosis, leveraging the advantages of PLGA, folate targeting, and the integration of therapeutic and imaging agents. Keywords: cancer; chlorambucil; drug carrier; IR780; PLGA nanoparticle; theragnostic; Introduction Poly(ᴅ,ʟ-lactic-co-glycolic acid) (PLGA), a copolymer of poly(lactic acid

Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

• Sebastian Pieper,
• Hannah Onafuye,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Martin Michaelis and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 2062–2072, doi:10.3762/bjnano.10.201

• incorporation into the lipophilic PLGA nanoparticle matrix. This explanation is consistent with data showing that PLGA nanoparticle degradation is unlikely to occur in a 24 h timeframe [50][52]. More sustained release patterns have been shown to be achievable by alternative nanoparticle approaches based on PLGA

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• nanoparticles were studied for glioma therapy by Qian et al. where a PLGA nanoparticle surface was modified with CS and cellular uptake of nanoparticles was determined. They showed that cellular uptake is related to chitosan concentration and particle size. According to their results, chitosan modification

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

• Maria J. Ramalho,
• Joana A. Loureiro,
• Bárbara Gomes,
• Manuela F. Frasco,
• Manuel A. N. Coelho and
• M. Carmo Pereira

Beilstein J. Nanotechnol. 2015, 6, 1306–1318, doi:10.3762/bjnano.6.135

• suffer a decrease in the presence of sucrose (p > 0.05). This could be explained by sucrose adsorption on the NPs surface. Calcitriol release from the PLGA nanoparticle The release of calcitriol entrapped in PLGA NPs was carried out in PBS (0.01 M, pH 7.4 at 37 °C) and the results are presented in Figure

• and subcultured. PLGA nanoparticle preparation PLGA NPs were prepared using the single emulsion solvent evaporation technique. For that purpose, 10 mg of PLGA was dissolved in 0.1 mL of ethyl acetate, and for encapsulation, 1 mg of vitamin was added. PLGA NPs for the entrapment of coumarin-6 were also

• . Lyophilization was carried out in a BenchTopTM K series freeze-dryer (VirTis, NY, USA) at 5 × 10−5 bar and −95 °C for 48 h. PLGA nanoparticle physicochemical characterization The size, polydispersity index (PDI), zeta potential, morphology, vitamin loading capacity and encapsulation efficiency were the