Nanoparticle delivery systems for HIV pre-exposure prophylaxis (PrEP): advances and challenges

• Sonia Zahara and
• Björn M. Reinhard

Beilstein J. Nanotechnol. 2026, 17, 839–853, doi:10.3762/bjnano.17.60

• Sonia Zahara Bjorn M. Reinhard Dept. of Chemistry and The Photonics Center, Boston University, Boston, MA 02215, United States 10.3762/bjnano.17.60 Abstract HIV pre-exposure prophylaxis (PrEP) encompasses antiviral drugs or formulations that aim to prevent the establishment of a permanent

• infection if exposure occurs. Conventional oral PrEP approaches require a daily drug regimen for effective prophylaxis, which can become burdensome, and pill fatigue creates challenges for adherence. There is, consequently, interest in the development of long-acting formulations of antiretrovirals that

• provide protection over extended periods of time after a single treatment. Nanoformulations and nanoparticle delivery strategies play an important role in achieving long acting (LA)-PrEP. This manuscript reviews emerging nanoparticle delivery platforms for LA-PrEP with a particular focus on four distinct

Ultrathin hydrophobic films based on the metal organic framework UiO-66-COOH(Zr)

• Miguel A. Andrés,
• Clemence Sicard,
• Christian Serre,
• Olivier Roubeau and
• Ignacio Gascón

Beilstein J. Nanotechnol. 2019, 10, 654–665, doi:10.3762/bjnano.10.65

• radiation source operated at 40 kV and 80 mA (average Kα radiation λ = 1.5418 Å). The sorption measurements were performed at 77 K on a BEL Japan Belsorp Mini apparatus using N2 as the probing gas. The samples were outgassed at 50 °C under vacuum for 24 h (BEL Japan, Belsorp Prep). Scanning electron

Evaluation of preparation methods for suspended nano-objects on substrates for dimensional measurements by atomic force microscopy

• Petra Fiala,
• Daniel Göhler,
• Benno Wessely,
• Michael Stintz,
• Giovanni Mattia Lazzerini and
• Andrew Yacoot

Beilstein J. Nanotechnol. 2017, 8, 1774–1785, doi:10.3762/bjnano.8.179

• procedure (Plasma Prep II, SPI Supplies) was chosen. A study of cleaning methods for silicon has been undertaken in [15]. The application of conditioned samples on the conditioned substrates were performed by four liquid phase preparation methods and two gas phase preparation methods as summarised in Table

Dielectrophoresis of gold nanoparticles conjugated to DNA origami structures

• Anja Henning-Knechtel,
• Matthew Wiens,
• Mathias Lakatos,
• Andreas Heerwig,
• Frieder Ostermaier,
• Nora Haufe and
• Michael Mertig

Beilstein J. Nanotechnol. 2016, 7, 948–956, doi:10.3762/bjnano.7.87

• 30 s using a SPI supplies Plasma prep II machine. A volume of 10 µL of the DNA origami structures was adsorbed on the grid for 5 min and wicked away. Then, a 0.1% uranyl formate solution (5 µL) was added for 5 min and again wicked away. Finally, the grid was gently washed with double-distilled water

Reconstitution of the membrane protein OmpF into biomimetic block copolymer–phospholipid hybrid membranes

• Matthias Bieligmeyer,
• Franjo Artukovic,
• Stephan Nussberger,
• Thomas Hirth,
• Thomas Schiestel and
• Michaela Müller

Beilstein J. Nanotechnol. 2016, 7, 881–892, doi:10.3762/bjnano.7.80

• , 61.57 and 29.55 µL of the phospholipid solution, respectively. From these mixtures, giant unilamellar vesicles (GUV) were formed using the electroformation technique [53]. For mixtures comprising of PIPEO877 and PIPEO3188, an alternating voltage of 3 V at 70 Hz was applied with the Vesicle Prep Pro