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Search for "RNA delivery" in Full Text gives 5 result(s) in Beilstein Journal of Nanotechnology.

Serum heat inactivation diminishes ApoE-mediated uptake of D-Lin-MC3-DMA lipid nanoparticles

  • Demian van Straten,
  • Luuk van de Schepop,
  • Rowan Frunt,
  • Pieter Vader and
  • Raymond M. Schiffelers

Beilstein J. Nanotechnol. 2025, 16, 740–748, doi:10.3762/bjnano.16.57

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  • a crucial part during pre-clinical nanoparticle development. The influence of the protein corona is particularly evident for the efficacy of lipid nanoparticles used for RNA delivery. Lipid nanoparticles (LNPs) protect the encapsulated RNA from premature clearance and simultaneously facilitate the
  • uptake in HMEC-1, U87 or MDA-MB-231 cells. Moreover, no effect of ApoE3 supplementation was observed in any of the cell lines, indicating limited ApoE-dependent uptake of C12 LNPs (Figure 4). To assess whether differences in uptake correspond to variations in RNA delivery efficiency, the two formulations
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Published 30 May 2025

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

  • Ana Cubillo Alvarez,
  • Dylan Maguire and
  • Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

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Published 27 Mar 2025

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

  • Naths Grazia Sukubo,
  • Paolo Bigini and
  • Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

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  • into clinical practice requires overcoming key challenges, such as ensuring molecular stability, achieving targeted delivery, and minimizing immune activation. Ongoing research is addressing these barriers by advancing RNA delivery systems [77]. For example, mesoporous silica NPs have been utilized to
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Published 31 Jan 2025

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

  • Selin Akpinar Adscheid,
  • Akif E. Türeli,
  • Nazende Günday-Türeli and
  • Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

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  • ; intranasal delivery; liposomes; nanomedicine; nanostructured lipid carriers (NLCs); polymer nanoparticles; RNA delivery; solid lipid nanoparticles (SLNs); Introduction The central nervous system (CNS) consists of the brain and the spinal cord and is considered the body’s processing and control center. While
  • critical literature reviews on N2B delivery of peptides and proteins. Considering the recent advancements and publications in the field, we highlight N2B delivery of biopharmaceuticals while emphasizing mAbs, RNA delivery, and NP functionalization techniques for better targeting the brain [150]. Despite
  • were treated with the NPs, the median survival was increased by a factor of 1.37 [155]. Regarding RNA delivery, recent literature specifically stresses the delivery of siRNA. siRNAs are regarded as an effective and attractive strategy to inhibit specific genes; therefore, there is the possibility of
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Published 12 Nov 2024

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

  • Qixiong Lin,
  • Yueyou Peng,
  • Yanyan Wen,
  • Xiaoqiong Li,
  • Donglian Du,
  • Weibin Dai,
  • Wei Tian and
  • Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

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  • shows improved RNA delivery efficiency and overcomes the obstacles of body clearance, insufficient targeting, and low biocompatibility [115]. PLGA NPs loaded with siRNA-E7 and PTX were synthesized for cervical cancer treatment. siRNA-E7 enables the knockdown of E7, which leads to upregulation of the
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Published 27 Feb 2023
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