Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• specific biological targets. This study evaluated the biocompatibility of Fe3O4 NPs, Teucrium polium (T. polium) extract, rutin, and the corresponding complexes on the liver tissue of healthy white Wistar rats. The impact profile of the synthesized Fe3O4 NPs (15 ± 4 nm), rutin, T. polium extract, and their

• samples on the liver of Wistar rats was identified. Keywords: biocompatibility; hepatotoxicity; iron oxide (Fe3O4) nanoparticle; rutin; Teucrium polium (T. polium); Introduction Leveraging nanotechnology, personalized medicine, and interdisciplinary collaboration is essential for overcoming the complex

• issue in biomedicine with significant potential for practical application. In this work, we studied the biocompatibility and hepatotoxicity of Fe3O4 NPs both individually and in combination with plant extract from Teucrium polium (T. polium) and its active component rutin on the liver of healthy white