Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

• Horacio Emanuel Jerez,
• Yamila Roxana Simioni,
• Kajal Ghosal,
• Maria Jose Morilla and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

• Technology, Jadavpur University, 188, Raja Subodh Chandra Mallick Rd., Jadavpur, Kolkata 700032, West Bengal, India 10.3762/bjnano.15.46 Abstract Sodium alendronate (ALN) is a very hydrosoluble and poorly permeable molecule used as an antiresorptive agent and with vascular anticalcifying capacity. Loaded

• , not only surpassing that of free ALN but also that of dexamethasone. Keywords: alendronate; archaeolipids; endothelial; inflammation; Introduction Many acute lethal events and chronic inflammatory diseases are mediated by initial or consequential damage to the vascular endothelium. Endothelial

• , besides targeting areas of active bone remodeling and resorption [5] and osteoclasts, nitrogenous bisphosphonates have been reported to reduce vascular calcification, through direct or indirect interaction with the endothelium [1][6]. Alendronate sodium (ALN) (CAS 121268-17-5, 4-amino-1-hydroxybutylidine

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• capability and were used to decrease the level of proinflammatory cytokines, including TNF-α and IL-6, at the inflammatory sites. As another example, an alendronate-coated nanoceria (CeAL) nanozyme was reported by Zhou et al. for both ROS and RNS scavenging [107]. Other RNS scavenging nanomaterials such as

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• procedure for rats. (b) MRI visualization of the infarcted regions. Adapted with permission from [26]. Copyright 2021 American Chemical Society. This content is not subject to CC BY 4.0. Distribution of K7M2 cell membrane-coated hollow manganese dioxide nanoparticles loaded with alendronate and the

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• with higher turnover rates [33]. The authors used alendronate as a surface-exposed ligand for directing bortezomib-loaded nanoparticles consisting of poly(ᴅ,ʟ-lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) to the bone microenvironment, which resulted in a 9.6-fold increase of bone

• localization of the functionalized nanoparticles relative to the non-functionalized nanoparticles. Additionally, the loaded PLGA–PEG–alendronate nanoparticles demonstrated satisfactory results in myeloma growth inhibition and overall survival of the murine models. Considering the toxicity of bortezomib

• the improvement of the overall therapeutic efficacy. A targeted NDDS for the co-delivery of ponatinib and SAR302503 (selective JAK2 inhibitor) for efficient CML treatment was developed by Mu and co-workers [47]. The authors employed alendronate-decorated PLA–PEG micelles for BM targeting. Both

Advanced hybrid nanomaterials

• Andreas Taubert,
• Fabrice Leroux,
• Pierre Rabu and
• Verónica de Zea Bermudez

Beilstein J. Nanotechnol. 2019, 10, 2563–2567, doi:10.3762/bjnano.10.247

• is simultaneously employed as a contrast agent in magnetic resonance imaging (MRI) and for local heating therapy using magnetic particle hyperthermia [33]. In vitro hyperthermia tests showed efficiency in inoculating mouse breast cancer cells. Another study reports the use of alendronate-coated gold

• nanoparticles [34]. The resulting gold–alendronate nanoplatform combines antitumor activity through drug delivery and photothermal therapy, as illustrated in vitro on the inhibition of prostate cancer cells. In the field of hybrid coordination networks, new lanthanide-based networks synthesized by a solvo

Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment

• Anouchka Plan Sangnier,
• Romain Aufaure,
• Laurence Motte,
• Claire Wilhelm,
• Erwann Guenin and
• Yoann Lalatonne

Beilstein J. Nanotechnol. 2018, 9, 2947–2952, doi:10.3762/bjnano.9.273

• with the same molecule used as reductant, coating and therapeutic agent has been developed in a one-pot, one-phase process using alendronate, a drug from the bisphosphonate family known for its antitumor effects. In addition, the core made of gold nanoparticles (NPs) brings thermal functionalities

• under irradiation within the first biological window (650–900 nm). The Au@alendronate nanoplatform thus provided a combined antitumor activity through drug delivery and photothermal therapy. Au@alendronate NPs inhibited in vitro the proliferation of prostate cancer cells (PC3) in a dose-dependent manner

• , with an IC50 value of 100 µM. Under NIR irradiation a temperature increase was observed leading to a reduction of the IC50 value to 1 µM, with total tumor cell death at 100 µM. Keywords: alendronate; bisphosphonate; cancer treatment; gold nanoparticles; photothermia; Findings Bisphosphonates (BPs