Nanomaterials for biomedical applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Filippo Pierini,
• Seda Kizilel and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 1499–1503, doi:10.3762/bjnano.16.105

• well-suited for orthopedic implants. Likewise, the addition of silver nanoparticles provides antibacterial properties for the material. This action is helping to prevent infection during the recovery time [28][29]. One of the major advantages of using nanomaterials in tissue engineering is that they

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

Synthesis and antibacterial properties of nanosilver-modified cellulose triacetate membranes for seawater desalination

• Lei Wang,
• Shizhe Li,
• Kexin Xu,
• Wenjun Li,
• Ying Li and
• Gang Liu

Beilstein J. Nanotechnol. 2025, 16, 1380–1391, doi:10.3762/bjnano.16.100

• rates of the Ag@PCTA membrane were comparable to those of the parent CTA membrane. Keywords: antibacterial properties; cellulose triacetate; nanosilver; seawater desalination; Introduction As the global population continues to grow at a rapid pace, the demand for freshwater resources is escalating

• significant attention for their ability to enhance the antibacterial properties of membrane materials, effectively addressing critical issues such as biofouling and microbial contamination in water treatment systems. These nanomaterials, characterized by their high surface area-to-volume ratio, tunable

• oxygen species (ROS) that damage bacterial cell membranes and DNA [19]. The incorporation of these nanomaterials into seawater desalination membranes not only significantly improves salt rejection and water flux but also markedly enhances antibacterial properties, thereby extending the operational

Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems

• Alejandro Llamedo,
• Marina Cano,
• Raquel G. Soengas and
• Francisco J. García-Alonso

Beilstein J. Nanotechnol. 2025, 16, 1350–1366, doi:10.3762/bjnano.16.98

• micelles [102]. The nano-encapsulated complexes maintained their antibacterial properties, improving solubility and stability. In addition, reduced toxicity and side effects were observed for the nano-encapsulated Ag-NHC complexes compared to the free metallodrug. Additionally, the encapsulation system

• cell membranes. Following membrane degradation, copper-released ions penetrate into the bacterial cell causing oxidative stress by production of ROS and subsequent degradation of the DNA [114][115]. Recent research has focused on the antibacterial properties of copper complexes derived from quinolones

Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2025, 16, 1025–1067, doi:10.3762/bjnano.16.77

• substrate prepared by sulfonation (Figure 16). The material, which exhibits a bifunctional system of antioxidants and antibacterial properties on its surface, was employed as a model implant to effectively treat diabetic bone defects and restore the integration and remodeling of the implant and surrounding

Supramolecular hydration structure of graphene-based hydrogels: density functional theory, green chemistry and interface application

• Hon Nhien Le,
• Duy Khanh Nguyen,
• Minh Triet Dang,
• Huyen Trinh Nguyen,
• Thi Bang Tam Dao,
• Trung Do Nguyen,
• Chi Nhan Ha Thuc and
• Van Hieu Le

Beilstein J. Nanotechnol. 2025, 16, 806–822, doi:10.3762/bjnano.16.61

• nanocomposite were estimated to be 24.39% and 19.08%, respectively. Antibacterial properties of graphene oxide–nanosilica–zinc hydroxide in hydrogel and in coating structures The EDS analysis in Table 2 showed that the solid nanocomposite of GO-SG-ZH hydrogel was composed of 12.81% zinc atoms (derived from the

Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Muhammad Waqas,
• Ahsan Nazir and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 591–612, doi:10.3762/bjnano.16.46

• antibacterial properties of PU nanofibrous membranes [162]. PU/gelatin and PU/cobalt nitrate were used to create mixed nanofibers scaffolds used to develop wound dressings [162][163]. It was shown that cobalt nitrate added to the PU wound dressing resulted in improved physicochemical properties, blood

Clays enhanced with niobium: potential in wastewater treatment and reuse as pigment with antibacterial activity

• Silvia Jaerger,
• Patricia Appelt,
• Mario Antônio Alves da Cunha,
• Fabián Ccahuana Ayma,
• Ricardo Schneider,
• Carla Bittencourt and
• Fauze Jacó Anaissi

Beilstein J. Nanotechnol. 2025, 16, 141–154, doi:10.3762/bjnano.16.13

• Guarapuava region in conjunction with niobium, an abundant metal in Brazil, is easily synthesized, cost-effective, and has potential to be used as a pigment in commercial paints. Moreover, it exhibits antibacterial properties against pathogens responsible for various diseases, including ocular and ear

Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material

• Veronika Pálos,
• Krisztina S. Nagy,
• Rita Pázmány,
• Krisztina Juriga-Tóth,
• Bálint Budavári,
• Judit Domokos,
• Dóra Szabó,
• Ákos Zsembery and
• Angela Jedlovszky-Hajdu

Beilstein J. Nanotechnol. 2024, 15, 781–796, doi:10.3762/bjnano.15.65

• antibacterial properties is limited due to the encapsulation of certain nanoparticles within the fibers [23]. One of the most common approaches is the introduction of antibiotics. However, with the misuse and/or overuse of these types of drugs, there is the risk of antibiotic resistance (AMR), which is one of

• strategies to fight bacterial pathogens with similar effects to antibiotics and silver is essential. In our study, inorganic salts, namely Zn(O2CCH3)2 and Sr(NO3)2, were added to the polymer fibers. These salts possess antibacterial properties and stimulate cell proliferation as well as tissue regeneration

Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity

• Nguyen Thi Thanh Tu,
• T. Lan-Anh Vo,
• T. Thu-Trang Ho,
• Kim-Phuong T. Dang,
• Van-Dung Le,
• Phan Nhat Minh,
• Chi-Hien Dang,
• Vinh-Thien Tran,
• Van-Su Dang,
• Tran Thi Kim Chi,
• Hieu Vu-Quang,
• Radek Fajgar,
• Thi-Lan-Huong Nguyen,
• Van-Dat Doan and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2023, 14, 781–792, doi:10.3762/bjnano.14.64

• antibacterial agents. One of the advantages of AgNPs over bulk metal or salts is their ability to controllably release silver as ions or particles, resulting in prolonged protection against bacteria [20]. While the specific mechanism of their antibacterial properties is not fully understood, mechanisms such as

• antibacterial properties can serve as a source of silver ions. Another mechanism involves the electrostatic attraction between negatively charged microbial cells and positively charged AgNPs [25]. Because of their affinity to sulfur proteins and through electrostatic attraction, silver ions can bind to both

• . Thus, AgNPs@Lac/Alg-0.7 was selected for assessment of its catalytic and antibacterial properties in this study. Catalytic degradation of contaminants Toxic organic dyes pose a serious threat to the environment, and their non-biodegradability in aqueous media has led to the consideration of various

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

• Se-Kwon Kim,
• Sesha Subramanian Murugan,
• Pandurang Appana Dalavi,
• Sebanti Gupta,
• Sukumaran Anil,
• Gi Hun Seong and
• Jayachandran Venkatesan

Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92

• ). Besides this, significant antibacterial properties against Staphylococcus epidermidis have been found [99]. Coating materials containing chitosan, bioactive glass, and AgNPs were developed by using the electrophoretic deposition method. The produced material was coated on stainless steel 316 substrates

• release of copper ions from the composite was investigated by soaking it into a buffer solution. In addition, biological assays were done with MC3T3-E1 cells. It has been found that the developed material is biocompatible and enhances osteogenic gene expression. Besides this, remarkable antibacterial

• properties against Escherichia coli and Staphylococcus aureus were obtained [87]. In another study, Lu et al. (2018) developed a scaffolding system of copper ions incorporated in carboxymethyl chitosan and alginate for bone tissue repair. The porous size of the scaffolds was in the range of 45 to 107 μm and

Spindle-like MIL101(Fe) decorated with Bi₂O₃ nanoparticles for enhanced degradation of chlortetracycline under visible-light irradiation

• Chen-chen Hao,
• Fang-yan Chen,
• Kun Bian,
• Yu-bin Tang and
• Wei-long Shi

Beilstein J. Nanotechnol. 2022, 13, 1038–1050, doi:10.3762/bjnano.13.91

• –organic frameworks; MIL101(Fe); photocatalysts; Z-scheme heterojunction; Introduction Tetracyclines, as the second most widely used antibiotic in the world, have been widely applied in clinics, aquaculture, and livestock due to its broad-spectrum antibacterial properties and low price [1][2

Bioselectivity of silk protein-based materials and their bio-inspired applications

• Hendrik Bargel,
• Vanessa T. Trossmann,
• Christoph Sommer and
• Thomas Scheibel

Beilstein J. Nanotechnol. 2022, 13, 902–921, doi:10.3762/bjnano.13.81

• biomaterials and medical devices with antifouling and antibacterial properties, but with reduced susceptibility to enzymatic degradation [85]. General advantages of AMPs/HDPs and mimicking polymer systems over antibiotics as a new generation of antimicrobial agents are their functional diversity, broad

• antimicrobial features [50]. Several studies reported antibacterial properties, reduced biofilm formation, and bacterial repellency of both natural silkworm [127][128][129] and spider silk threads and cocoons [130][131][132][133][134][135][136]. However, the status of the intrinsic properties of silk materials

Zinc oxide nanostructures for fluorescence and Raman signal enhancement: a review

• Ioana Marica,
• Fran Nekvapil,
• Maria Ștefan,
• Cosmin Farcău and
• Alexandra Falamaș

Beilstein J. Nanotechnol. 2022, 13, 472–490, doi:10.3762/bjnano.13.40

• their wide bandgap energy (3.3–3.7 eV), strong luminescence [4][5], antibacterial properties, and UV-protection properties. Additionally, ZnO nanomaterials can be designed into various morphologies, such as nanoparticles, nanoneedles, nanorods, nanocages, nanocombs, and nanoflowers [5][6][7][8]. Hybrid

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• potential. Thus, the optimized TiO2 nanoparticle concentration of the PCL/5TiO2 sample exhibited improved biological and antibacterial properties for bone tissue engineering, thereby improving the properties of orthopedic devices [60]. Ko et al. found that titanium covered with a double layer of gold nps

• tissue, the material was covered with a nanoscale hydroxyapatite (nHA) coating and its efficacy was compared to the material without nHA coating. Interestingly, both materials showed antibacterial properties against Staphylococcus aureus, but the nHA-coated material was found to be more biocompatible [62

A comprehensive review on electrospun nanohybrid membranes for wastewater treatment

• Senuri Kumarage,
• Imalka Munaweera and
• Nilwala Kottegoda

Beilstein J. Nanotechnol. 2022, 13, 137–159, doi:10.3762/bjnano.13.10

• , modified chitin, cellulose acetate (CA) and chitosan (CS) have been electrospun as nanohybrids and have been used in a variety of applications [7][8]. Regarding the health sector, the enhanced biocompatibility, antibacterial properties, and cell compatibility has made ENHs great candidates to deliver

Characterization, bio-uptake and toxicity of polymer-coated silver nanoparticles and their interaction with human peripheral blood mononuclear cells

• Sahar Pourhoseini,
• Reilly T. Enos,
• Angela E. Murphy,
• Bo Cai and
• Jamie R. Lead

Beilstein J. Nanotechnol. 2021, 12, 282–294, doi:10.3762/bjnano.12.23

• . Discussion Because of the antibacterial properties of AgNPs and their use in medical applications, there have been several studies on their effects on human blood cells [26][27][28]. Most of the previous studies investigating uptake and toxicity of AgNPs in human PBMCs have failed to report procurement

A review on the biological effects of nanomaterials on silkworm (Bombyx mori)

• Sandra Senyo Fometu,
• Guohua Wu,
• Lin Ma and
• Joan Shine Davids

Beilstein J. Nanotechnol. 2021, 12, 190–202, doi:10.3762/bjnano.12.15

• ), graphene oxide, silver nanoparticles (Ag NPs) [24][25][26], quantum dots, and superparamagnetic particles [27] have been reported to have antibacterial properties against Streptococcus mutans [28] and Xanthomonas perforans, antifungal properties against Fusarium oxysporum [27] and Fusarium graminearum [29

• Ag NPs exhibited a smooth surface with significant changes in the silk diameter. Ag NPs concentrations of 0.20% and 0.02% were reported to promote the synthesis of silk proteins, improve the mechanical properties of the silk fibers, and to improve the antibacterial properties of the silk. Figure 2

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

• Matías Guerrero Correa,
• Fernanda B. Martínez,
• Cristian Patiño Vidal,
• Camilo Streitt,
• Juan Escrig and
• Carol Lopez de Dicastillo

Beilstein J. Nanotechnol. 2020, 11, 1450–1469, doi:10.3762/bjnano.11.129

• antibacterial properties, since they can exhibit both effects [1]. Furthermore, the antibacterial effectiveness of most compounds differs depending on the type of bacteria exposed to these compounds. Gram-positive and Gram-negative bacteria, for example, are categories widely studied due to their different

• Aspergillus tamarri and AgNO3. The resulting Ag NPs showed a potential antimicrobial activity against Candida albicans and Staphylococcus aureus [100]. Spherical Ag NPs, with a diameter of 16 nm, showed antibacterial properties against the human pathogens Escherichia coli and Pseudomonas aeruginosa [101

• ]. Chen et al. (2019) also developed an antimicrobial-based biocomposite containing Ag NPs with good antibacterial properties against E. coli and S. aureus, as shown by the disk diffusion method [102]. Copper nanoparticles are nanomaterials with good chemical stability, heat resistance, and excellent

Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms

• Mykola Borzenkov,
• Piersandro Pallavicini,
• Angelo Taglietti,
• Laura D’Alfonso,
• Maddalena Collini and
• Giuseppe Chirico

Beilstein J. Nanotechnol. 2020, 11, 1134–1146, doi:10.3762/bjnano.11.98

• results regarding antibacterial activity. The advances in the field of nanomaterials exhibiting antibacterial activity are well summarized in recent reviews [1][7][8][9]. In particular, the antibacterial properties of silver nanoparticles (Ag NPs) and Ag-NP-based polymeric materials are the most

• formation are controversial as the Ag nanoparticles seem to be effective against the Gram-negative but not so much against the Gram-positive strains [6]. The antibacterial properties of a wide range of nanoparticles and their corresponding nanocomposites, such as ZnO [17][18], TiO2 [19][20], Fe3O4 [21][22

• studied. The state-of-the art in antimicrobial polymeric nanoparticles, with an emphasis on the relationship between their structure and activity, is well presented in a recent review [29]. The antibacterial properties of solid lipid nanoparticles are also a subject of specific research interest as they

Gram-scale synthesis of splat-shaped Ag–TiO₂ nanocomposites for enhanced antimicrobial properties

• Mohammad Jaber,
• Asim Mushtaq,
• Kebiao Zhang,
• Jindan Wu,
• Dandan Luo,
• Zihan Yi,
• M. Zubair Iqbal and
• Xiangdong Kong

Beilstein J. Nanotechnol. 2020, 11, 1119–1125, doi:10.3762/bjnano.11.96

• antibacterial properties of TiO2 in the presence of silver were examined. The formation of Ag–TiO2 NCs was analyzed through various characterization techniques. The cell viability experimental results demonstrated that the Ag–TiO2 NCs have good biocompatibility. The antibacterial activity of the prepared Ag

• –TiO2 NCs was tested against the Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacterial strains. The Ag–TiO2 NCs exhibited promising and superior antibacterial properties compared to TiO2 nanospheres as confirmed by the bacterial growth and inhibition zone

• antibiotics, leading to environmental toxicity and damage of target organs in the human body [1]. Also, these materials rapidly dissolve in the human body creating numerous clinical risks [2][3]. In spite of the desirable antibacterial properties, the traditional quaternary ammonium salts (QASs) and the

Wet-spinning of magneto-responsive helical chitosan microfibers

• Dorothea Brüggemann,
• Johanna Michel,
• Naiana Suter,
• Matheus Grande de Aguiar and
• Michael Maas

Beilstein J. Nanotechnol. 2020, 11, 991–999, doi:10.3762/bjnano.11.83

• polysaccharides such as alginate, hyaluronic acid or chitosan, are widely used as biocompatible materials since they are biochemically similar to the native extracellular matrix (ECM) [16]. Chitosan is a biopolymer that combines excellent biocompatibility, low toxicity and antibacterial properties with a low

Silver-decorated gel-shell nanobeads: physicochemical characterization and evaluation of antibacterial properties

• Marta Bartel,
• Katarzyna Markowska,
• Marcin Strawski,
• Krystyna Wolska and
• Maciej Mazur

Beilstein J. Nanotechnol. 2020, 11, 620–630, doi:10.3762/bjnano.11.49

• of composite nanobeads with antibacterial properties. The particles consist of polystyrene cores that are surrounded by sulfonic gel shells with embedded silver nanoparticles. The nanocomposite beads are prepared by sulfonation of polystyrene particles followed by accumulation of silver ions in the

• , respectively [25]. In another study, citrate-stabilized nanoparticles (average diameter of 9 nm) inhibited the growth of E. coli and S. aureus at 10 and 5 μg/mL, respectively [26]. We report herein on the synthesis of nanocomposites with antibacterial properties. The polystyrene nanobeads were modified with

• nanobeads, which likely stabilizes these structures. The hybrid particles reveal considerable antibacterial properties. This has been evaluated based on the determination of MIC and MBIC values and an estimation of bacterial viability through fluorescence staining. Experimental Chemicals All chemicals were

Luminescent gold nanoclusters for bioimaging applications

• Nonappa

Beilstein J. Nanotechnol. 2020, 11, 533–546, doi:10.3762/bjnano.11.42

• rigidify the surface resulting in a 28-fold increase in the PL of Au-MTU/Prot NCs compared to that of Au-MTU NCs. The resulting Au-MTU/Prot NCs displayed antibacterial properties with abilities to kill both Gram-positive and Gram-negative bacteria, which was shown using E. coli and SA strains. The addition

Novel hollow titanium dioxide nanospheres with antimicrobial activity against resistant bacteria

• Carol López de Dicastillo,
• Cristian Patiño,
• María José Galotto,
• Yesseny Vásquez-Martínez,
• Claudia Torrent,
• Daniela Alburquenque,
• Alejandro Pereira and
• Juan Escrig

Beilstein J. Nanotechnol. 2019, 10, 1716–1725, doi:10.3762/bjnano.10.167

• the S. aureus strain. Antimicrobial tests also revealed that hollow TiO2 nanospheres present promising activity when irradiated with UV light. In addition to the antibacterial properties, these hollow nanospheres could be used for photocatalytic purposes. This represents a first work that opens up