Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

• Ana Cubillo Alvarez Dylan Maguire Ruairi P. Brannigan School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland 10.3762/bjnano.16.34 Abstract This review explores the recent advancements in polymer-assisted delivery systems for antisense oligonucleotides (ASOs) and their

• optimise ASO-based therapeutics for more precise and effective disease treatments. Keywords: antisense oligonucleotides; enhanced delivery; gene transfection; intracellular uptake; locked nucleic acid (LNA); nanoparticles; peptide nucleic acid (PNA); personalised therapy; phosphorodiamidate morpholino

• cellular internalisation [14]. Antisense oligonucleotides (ASOs) are short, chemically engineered single- or double-stranded oligonucleotides (also known as small interfering RNA, siRNA) that bind to complementary RNA in a sequence-specific manner, causing the suppression, modification, or restoration of a

Polymer nanoparticles from low-energy nanoemulsions for biomedical applications

• Santiago Grijalvo and
• Carlos Rodriguez-Abreu

Beilstein J. Nanotechnol. 2023, 14, 339–350, doi:10.3762/bjnano.14.29

• by TEM) were surface-decorated with carbosilane cationic dendrons via carbodiimide chemistry [54] for conjugation with antisense oligonucleotides (ASO). The conjugated nanoparticles with a hydrodynamic diameter between 80 and 160 nm (depending on dendron generation) showed high colloidal stability

• composed of carbosilane dendron functionalized nanoparticles prepared from nanoemulsions as non-viral carriers for antisense oligonucleotides”, pages 113-123, Copyright (2014), with permission from Elsevier. This content is not subject to CC BY 4.0. (a) Partial phase diagram of the system PBS/Polysorbate

Internalization mechanisms of cell-penetrating peptides

• Ivana Ruseska and
• Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

• process [30]. Membrane perturbation as an internalization mechanism has also been proposed for the MPG-family of amphipathic peptides (Figure 2) [3][17][31]. MPG carriers are amphipathic peptides able to form stable complexes with antisense oligonucleotides, plasmid DNA, siRNA and peptides, which improve

High antiviral effect of TiO₂·PL–DNA nanocomposites targeted to conservative regions of (−)RNA and (+)RNA of influenza A virus in cell culture

• Asya S. Levina,
• Marina N. Repkova,
• Elena V. Bessudnova,
• Ekaterina I. Filippova,
• Natalia A. Mazurkova and
• Valentina F. Zarytova

Beilstein J. Nanotechnol. 2016, 7, 1166–1173, doi:10.3762/bjnano.7.108

• NA-based drugs of various nature [8][9][10][11][12][13][14][15][16]. However, there is still no unified concept for the most vulnerable regions of this segment. In this work, we attempt to find some relationships in this aspect for IAV segment 5. To deliver antisense oligonucleotides into cells, we