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Search for "apolipoprotein E" in Full Text gives 8 result(s) in Beilstein Journal of Nanotechnology.
Serum heat inactivation diminishes ApoE-mediated uptake of D-Lin-MC3-DMA lipid nanoparticles
Beilstein J. Nanotechnol. 2025, 16, 740–748, doi:10.3762/bjnano.16.57
- ) ionizable lipids. Cellular uptake and siRNA delivery efficiency of the LNPs were determined in media containing untreated or heat-inactivated serum. Mechanistically, we found that apolipoprotein E, a protein corona component that is crucial for MC3 LNP tropism, displayed reduced stability and functionality
- protein corona formation in vitro and prevent bias in LNP development. Keywords: apolipoprotein E; fetal calf serum; heat inactivation; lipid nanoparticle; protein corona; Introduction Nanotechnology has gained a strong foothold in the field of drug delivery, having significant promise to overcome the
- intravenously after which they are dependent on the adsorption of the plasma protein apolipoprotein E (ApoE) to their surface to efficiently target LDL-receptor expressing cells in the liver and deliver the siRNA cargo [25][26]. As the protein corona seems to play a pivotal role in LNP tissue distribution and
Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy
Beilstein J. Nanotechnol. 2025, 16, 561–580, doi:10.3762/bjnano.16.44
- ) influence of the APOE4 allele, that is, positive clinical trial outcomes tend to have a higher concentration of AβOs in the brain of individuals carrying the E4 allele of apolipoprotein E (APOE4). The origins of AβOs in AD patients remain a subject of debate and require further extensive research for a
Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer
Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23
- and exposure of the ionizable lipids at the surface of the LNPs. After dissociation of the PEGylated lipids, the naked surface of the particles containing the ionizable DLin-KC2-DMA, which is neutral in a biological environment, interacts with apolipoprotein E (ApoE), enabling ApoE liver-mediated
Key for crossing the BBB with nanoparticles: the rational design
Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72
- toxic effects and did not disrupt the BBB at the dose used [50]. At the same time, Lück published in his thesis that apolipoprotein E (ApoE) was adsorbed on the surface of nanoparticles coated with polysorbate 20, 40, 60 or 80 after their incubation in human plasma [51]. However, ApoE was not adsorbed
Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles
Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101
- attracted to NPs composed of hydrophobic core materials [30][31] resulting in a prolonged circulation time in blood [18]. Moreover, covalent attachment of apolipoprotein A–I and apolipoprotein E to the NP surface enables drug transport across the blood–brain barrier [32]. Here, both proteins were identified
Optimized design of a nanostructured SPCE-based multipurpose biosensing platform formed by ferrocene-tethered electrochemically-deposited cauliflower-shaped gold nanoparticles
Beilstein J. Nanotechnol. 2015, 6, 1840–1852, doi:10.3762/bjnano.6.187
- fractal gold nanostructures for electrodes endowed with very large surface areas useful for the sensitive detection of apolipoprotein E, which is a protein biomarker for Alzheimer’s disease [18]. The preparation of the platforms was achieved in a straightforward manner in few steps. Firstly, home-prepared
In vitro and in vivo interactions of selected nanoparticles with rodent serum proteins and their consequences in biokinetics
Beilstein J. Nanotechnol. 2014, 5, 1699–1711, doi:10.3762/bjnano.5.180
- protein in the circulation), serum albumin (most abundant blood multi-functional protein), fibrinogen beta (modulation of blood coagulation and opsonisation of foreign bodies [8]), and apolipoprotein E (ApoE) (mediating protein for transcytosis across biological membranes [9][10]). More detected proteins
- groups, but also with polyethylene glycol (PEG) or other polymers or polyelectrolytes and, finally, with tightly grafted plasma proteins (albumin or apolipoprotein E). All AuNP had been radioactively labeled with 198Au by neutron activation in a nuclear research reactor. Most of these studies were
- compared after intratracheal instillation or intravenous injection of 5 nm 198AuNP; Lipka et al. [14], biokinetics of protein–AuNP conjugates with albumin or apolipoprotein E versus polyelectrolytes and a small ionic ligand are compared after intravenous injection of 15 nm and 80 nm 198AuNP; Schäffler et
The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver
Beilstein J. Nanotechnol. 2014, 5, 1432–1440, doi:10.3762/bjnano.5.155
- process that is dependent on the LDL receptor and apolipoprotein E, by hepatocytes. Gene expression analysis of pro-inflammatory markers such as tumor necrosis factor alpha (TNFα) or chemokine (C-X-C motif) ligand 10 (Cxcl10) indicated that 48 h after injection internalized nanocrystals did not provoke
- ]. During peripheral processing within adipose tissues, the remaining lipid micelles become enriched with apolipoprotein E within the vascular system. These particles are then taken up primarily by hepatocytes in a process that is dependent on hepatic lipoprotein receptors such as the LDL receptor and its
- ligand apolipoprotein E, indicating that the nanocrystals did not influence the specificity of the metabolic process [18]. Here we show that substantial amounts of injected QDs–lipid micelles were not only internalized by hepatocytes but also targeted to non-parenchymal hepatic cells, most likely Kupffer
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