Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

• Horacio Emanuel Jerez,
• Yamila Roxana Simioni,
• Kajal Ghosal,
• Maria Jose Morilla and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

• , not only surpassing that of free ALN but also that of dexamethasone. Keywords: alendronate; archaeolipids; endothelial; inflammation; Introduction Many acute lethal events and chronic inflammatory diseases are mediated by initial or consequential damage to the vascular endothelium. Endothelial

• with sufficient effectivity under dynamic conditions [26]. However, simple in vitro experimental settings employing static conditions could anticipate both potential toxicity and therapeutic effects. In this context, new natural biomaterials such as archaeolipids are being explored with growing

• IL-6 and IL-8 by HUVECs even in the presence of TNF-α. Results Characterization of ALN-loaded nanovesicles The structural features of ALN-loaded nanovesicles are shown in Table 1. As reported previously, nanoarchaeosome bilayers contain archaeolipids displaying methyl groups perpendicular to their