Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• directions are proposed to overcome these obstacles and further enhance the mechanical properties of chitosan/PVA electrospun nanofibers, guiding their development for practical applications. Keywords: biomaterials; chitosan; electrospun nanofiber; mechanical properties; polyvinyl alcohol; Introduction In

• nanocomposites have been produced through the substantial utilization of nanoparticles. The development of fibrous nanocomposites or bio-nanocomposites, where the matrix and/or fillers are biomaterials, has been advanced in recent years by introducing nanoscale materials into electrospun fibers in the form of

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• relevant and challenging human diseases. This study demonstrates that mimicking cell membranes, particularly those of immune system cells, offers significant benefits by reducing the degradation of biomaterials by the host. The use of biocompatible coatings not only enhances treatment efficacy but also

Natural nanofibers embedded in the seed mucilage envelope: composite hydrogels with specific adhesive and frictional properties

• Agnieszka Kreitschitz and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 1603–1618, doi:10.3762/bjnano.15.126

• production of biofilms, encapsulation, or lubricants with medical application [106][110][111][116][117]. Our findings may also help to design pathogen-resistant lubricating biomaterials with low friction, which can be achieved in rather simply way by adding phenolic substances to the medical hydrogels [98

Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti

• Matheus Alves Siqueira de Assunção,
• Douglas Dourado,
• Daiane Rodrigues dos Santos,
• Gabriel Bezerra Faierstein,
• Mara Elga Medeiros Braga,
• Severino Alves Junior,
• Rosângela Maria Rodrigues Barbosa,
• Herminio José Cipriano de Sousa and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123

• on naturally occurring biomaterials have been used as an alternative to obtain metallic nanoparticles [32][33]. These do not involve any toxic chemicals and require less energy and synthesis time. Simple protocols have been used involving the reduction of metal ions using biological extracts as

A biomimetic approach towards a universal slippery liquid infused surface coating

• Ryan A. Faase,
• Madeleine H. Hummel,
• AnneMarie V. Hasbrook,
• Andrew P. Carpenter and
• Joe E. Baio

Beilstein J. Nanotechnol. 2024, 15, 1376–1389, doi:10.3762/bjnano.15.111

• aggregates form and are joined together through π stacking [45]. As mentioned earlier, quantification of the activation of intrinsic coagulation on SLIPS surfaces have not been fully investigated. For biomaterials, the intrinsic pathway has been shown to activate upon exposure, whereas in vivo the extrinsic

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• ) Tumor volume growth curves and (E) ex vivo weight of tumors at 14 days after treatment. Treatments included saline (control), targeted AuNCs, non-targeted AuNCs, with or without radiotherapy (RT). The figure was adapted from [122], Biomaterials, vol. 144, by G. Liang; X. Jin; S. Zhang; D. Xing, “RGD

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• . Also, alginate-based nanoparticles possess excellent mechanical and electrical properties, overcoming the limitations typically associated with biomaterials in sensing applications [73]. Drug delivery applications Alginate-based nanoparticles for smart DDSs Drug delivery systems are one of the areas in

Effect of wavelength and liquid on formation of Ag, Au, Ag/Au nanoparticles via picosecond laser ablation and SERS-based detection of DMMP

• Sree Satya Bharati Moram,
• Chandu Byram and
• Venugopal Rao Soma

Beilstein J. Nanotechnol. 2024, 15, 1054–1069, doi:10.3762/bjnano.15.86

• , and biomaterials for constructing flexible SERS substrates, owing to their numerous advantages over traditional options such as glass and silicon [31][32][33][34][35][36][37][38][39]. Detecting hazardous molecules, such as pesticides, explosives, and chemical threats (nerve agents) using flexible SERS

Interface properties of nanostructured carbon-coated biological implants: an overview

• Mattia Bartoli,
• Francesca Cardano,
• Erik Piatti,
• Stefania Lettieri,
• Andrea Fin and
• Alberto Tagliaferro

Beilstein J. Nanotechnol. 2024, 15, 1041–1053, doi:10.3762/bjnano.15.85

• biomaterials. Figure 3 was reproduced from [86] (© 2019 E. Mariani et al., published by MDPI, distributed under the terms of the Creative Commons Attribution 4.0 International License, https://creativecommons.org/licenses/by/4.0). Biofilm formation on an implanted biomaterial due to the presence of planktonic

Electrospun nanofibers: building blocks for the repair of bone tissue

• Tuğrul Mert Serim,
• Gülin Amasya,
• Tuğba Eren-Böncü,
• Ceyda Tuba Şengel-Türk and
• Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

• both trigger the bone healing process and provide mechanical support to damaged bone. Currently, research on bone healing has focused on the development of biomaterials that can be used as economic, biocompatible, and controllable bone substitutes. Studies have centered on biomaterials that can imitate

• natural bone structure with appropriate porosity and fulfill the functions of transport as well as the exchange of substances. Biomaterials should also help cells to adhere and maintain their normal proliferative and differentiation capacity. Nanofiber scaffolds are at the forefront of these types of

Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

• Horacio Emanuel Jerez,
• Yamila Roxana Simioni,
• Kajal Ghosal,
• Maria Jose Morilla and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

• with sufficient effectivity under dynamic conditions [26]. However, simple in vitro experimental settings employing static conditions could anticipate both potential toxicity and therapeutic effects. In this context, new natural biomaterials such as archaeolipids are being explored with growing

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• the conjugation of gold nanoparticles (AuNPs) with an anti-epithelial sodium channel (ENaC), known as a marker for arterial hypertension found in membrane platelets [186]. Beyond nanotechnology, the field has witnessed developments in metallic biomaterials for vascular tissue engineering. Titanium

• biomaterials for vascular interventions and cardiovascular therapeutics. As researchers continue to discover the intricacies of CVDs, the integration of metal-based materials holds promise for more effective clinical strategies. Challenges of metal-based nanoantioxidants in medicine and healthcare Metal-based

New application of bimetallic Ag/Pt nanoplates in a colorimetric biosensor for specific detection of E. coli in water

• Azam Bagheri Pebdeni,
• Mohammad N. AL-Baiati and
• Morteza Hosseini

Beilstein J. Nanotechnol. 2024, 15, 95–103, doi:10.3762/bjnano.15.9

• Department of Pharmaceutical Biomaterials and Medicinal Biomaterials Research Center,Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran 10.3762/bjnano.15.9 Abstract A fast and sensitive aptasensor was developed using nanoplates with peroxidase activity as a novel approach. E. coli

Determination of the radii of coated and uncoated silicon AFM sharp tips using a height calibration standard grating and a nonlinear regression function

• Perawat Boonpuek and
• Jonathan R. Felts

Beilstein J. Nanotechnol. 2023, 14, 1200–1207, doi:10.3762/bjnano.14.99

• nanostructured materials, for example, graphene, carbon nanotubes, nanoscale semiconductors, biomaterials, and molecules. Mechanical properties such as surface stiffness, adhesion, friction, electrostatics, and electrowetting can be measured [1][2][3][4]. In contact mode scanning, the contact area between the

Hierarchically patterned polyurethane microgrooves featuring nanopillars or nanoholes for neurite elongation and alignment

• Lester Uy Vinzons,
• Guo-Chung Dong and
• Shu-Ping Lin

Beilstein J. Nanotechnol. 2023, 14, 1157–1168, doi:10.3762/bjnano.14.96

• ; Introduction The surface features of biomaterials at the micro- and the nanoscale play a crucial role in modulating tissue responses and in determining the functional and temporal efficacy of implants [1]. Micro- and nanoscale surface structures affect cellular functions through micro- and nanometer-sized cell

• ]. Therefore, there is still a need to develop simple and cost-effective fabrication methods applicable to a wide range of nano- and micropatterns and biomaterials. In our previous studies, we have shown how nanosphere lens lithography (NLL) can be used with a low-cost ultraviolet light-emitting diode (UV-LED

Biomimetics on the micro- and nanoscale – The 25th anniversary of the lotus effect

• Matthias Mail,
• Kerstin Koch,
• Thomas Speck,
• William M. Megill and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2023, 14, 850–856, doi:10.3762/bjnano.14.69

• biological processes and surface interactions involved in the bioselective adhesion of mammalian cells. The second topic of the review was on repellence of microbes on protein-based material surfaces, highlighting the importance of materials made of recombinant spider silk proteins. Biomaterials that

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• nanoparticles (ISO/TR 7406 or ASTM E2524-08 standard) established that biomaterials that induce a critical hemolytic ratio of <5% can be considered safe for biological applications [46]. In our study, it was observed no hemolytic effects for BNZ, NLC-VEHICLE, and NLC-BNZ at different concentrations after 3 and

Molecular nanoarchitectonics: unification of nanotechnology and molecular/materials science

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2023, 14, 434–453, doi:10.3762/bjnano.14.35

• in a designed layered structure. As summarized in the review by Akashi and Akagi, LbL assembly is valuable as a pathway to the design and development of innovative biomaterials for tissue engineering [100]. Interfacial phenomena contribute significantly to material accumulation and property

New trends in nanobiotechnology

• Pau-Loke Show,
• Kit Wayne Chew,
• Wee-Jun Ong,
• Sunita Varjani and
• Joon Ching Juan

Beilstein J. Nanotechnol. 2023, 14, 377–379, doi:10.3762/bjnano.14.32

• nanobiotechnological processes to encourage the development of these converging technologies for a sustainable economic growth. The synthesis and the characterization of nanoscale biomaterials, the innovative applications of “smart nanoparticles”, and the technological/biological impact of nanoscale systems are just

• biocompatibility of the nanomaterials is also discussed. The thematic issue also recorded a work on the topic of “Self-assembly of amino acids toward functional biomaterials” [5], where the role of biomaterials in nanobiotechnology is discussed. In this review, the latest advances in amino acid self-assembly and

Antimicrobial and mechanical properties of functionalized textile by nanoarchitectured photoinduced Ag@polymer coating

• Jessica Plé,
• Marine Dabert,
• Helene Lecoq,
• Sophie Hellé,
• Lydie Ploux and
• Lavinia Balan

Beilstein J. Nanotechnol. 2023, 14, 95–109, doi:10.3762/bjnano.14.11

• Jessica Ple Marine Dabert Helene Lecoq Sophie Helle Lydie Ploux Lavinia Balan Université d’Orléans, Conditions Extrêmes Matériaux Haute Température et Irradiation CNRS UPR 3079, F-45000, Orléans, France Biomaterials Bioengineering INSERM/Université de Strasbourg U1121, Centre de Recherche en

Hydroxyapatite–bioglass nanocomposites: Structural, mechanical, and biological aspects

• Olga Shikimaka,
• Mihaela Bivol,
• Bogdan A. Sava,
• Marius Dumitru,
• Christu Tardei,
• Beatrice G. Sbarcea,
• Daria Grabco,
• Constantin Pyrtsac,
• Daria Topal,
• Andrian Prisacaru,
• Vitalie Cobzac and
• Viorel Nacu

Beilstein J. Nanotechnol. 2022, 13, 1490–1504, doi:10.3762/bjnano.13.123

• development of new synthetic biomaterials that are perfectly compatible with biological tissue and provide special functionalities for healing, regeneration, and substitution of diseased or injured bones, as an alternative to “allograft” and “autograft” transplantology methods, which have a number of

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

• Se-Kwon Kim,
• Sesha Subramanian Murugan,
• Pandurang Appana Dalavi,
• Sebanti Gupta,
• Sukumaran Anil,
• Gi Hun Seong and
• Jayachandran Venkatesan

Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92

• Se-Kwon Kim Sesha Subramanian Murugan Pandurang Appana Dalavi Sebanti Gupta Sukumaran Anil Gi Hun Seong Jayachandran Venkatesan Department of Marine Science and Convergence Engineering, College of Science and Technology, Hanyang University, Gyeonggi-do 11558, Korea Biomaterials Research Laboratory

• properties to bone graft substitutes. Therefore, to get all the three properties of bone graft substitutes, synthetic biomaterials are often mixed with growth factors and host-derived cells to increase bone formation [3]. Bone tissue engineering is the process of developing bone graft biomaterials with the

• combination of materials, growth factors, and cells [4]. Both natural and synthetic materials have been extensively studied for bone graft substitutes [5][6]. Natural biomaterials often are biocompatible, biodegradable, and less toxic to cells, whereas synthetic biomaterials have excellent mechanical strength

Bioselectivity of silk protein-based materials and their bio-inspired applications

• Hendrik Bargel,
• Vanessa T. Trossmann,
• Christoph Sommer and
• Thomas Scheibel

Beilstein J. Nanotechnol. 2022, 13, 902–921, doi:10.3762/bjnano.13.81

• Hendrik Bargel Vanessa T. Trossmann Christoph Sommer Thomas Scheibel Department of Biomaterials, University of Bayreuth, Prof.-Rüdiger-Bormann-Str. 1, 95447 Bayreuth, Germany Bayreuth Center of Material Science and Engineering (BayMat), University of Bayreuth, Universitätsstr. 30, 95440 Bayreuth

• . Engineering biomaterials that stimulate and interact with cell receptors to support binding and subsequent physiological responses of multicellular systems attracted much interest in the last years. Further to this, the increasing threat of multidrug resistance of pathogens against antibiotics to human health

• of bio-inspired selective surface modifications The increasing knowledge on natural receptor–ligand binding mechanisms led to various approaches in the last years to increase both cellular adhesion on surfaces of biomaterials and biosensors, as well as for therapeutic drug carrier systems against

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

• administration of new and efficient options for treating osteochondral lesions. This paper presents an overview of the recent advances in osteochondral tissue engineering resulting from the application of micro- and nanotechnology approaches in the structure of biomaterials, including biological and microscale

• application of such stimuli pave the way for the application of new and promising sources for re-engineering of biomaterials. In this paper, the native structure of articular cartilage is briefly described due to the importance of understanding its complex structure before designing a suitable construct

• . Afterward, recent advances in osteochondral tissue engineering resulting from the application of microspheres, nanoparticles, nanofibers, and nanotubes in the structure of biomaterials will be covered (Figure 1). Finally, the role of various cues such as biological cues, microscale/nanoscale topographical

Systematic studies into uniform synthetic protein nanoparticles

• Nahal Habibi,
• Ava Mauser,
• Jeffery E. Raymond and
• Joerg Lahann

Beilstein J. Nanotechnol. 2022, 13, 274–283, doi:10.3762/bjnano.13.22

• SPNPs made from blended proteins can serve as a promising drug delivery carrier owing to the ease of production, the composition versatility, and the control over their size, shape and dispersity. Keywords: nanogels; nanomedicine; particle characterization; protein-based biomaterials; Introduction As