Efficiency of single-pulse laser fragmentation of organic nutraceutical dispersions in a circular jet flow-through reactor

• Tina Friedenauer,
• Maximilian Spellauge,
• Alexander Sommereyns,
• Verena Labenski,
• Tuba Esatbeyoglu,
• Christoph Rehbock,
• Heinz P. Huber and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 711–727, doi:10.3762/bjnano.16.55

• laser fragmentation in liquids with ultrashort-pulsed lasers was studied in a circular jet reactor using curcumin and cannabidiol as model substances and single-pulse-per-volume element conditions to compare the fragmentation efficiency for these two nutraceuticals. Fragmentation efficiency based on the

• viability even at high curcumin concentrations. Keywords: antioxidant; cannabidiol; curcumin; drug; food additive; low degradation; nanoparticle; pulsed laser ablation in liquids; solubilization; Introduction Laser synthesis and processing of colloids (LSPC) has become increasingly popular over the last

• one passage of the jet passing the laser) in a liquid jet (Figure 1). The two organic model nutraceuticals curcumin and cannabidiol (CBD) were used to cover different material classes with different initial particle diameters. As triggering photomechanical fragmentation effects is intended [43], we

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• nanoemulsion formulation with a particle size of 91.20 nm increased the drug absorption into the brain via the intranasal route compared to the mucoadhesive suspension form [115]. The encapsulation of a poorly soluble drug, cannabidiol, into nanoemulsions for the treatment of epilepsy was also evaluated. The

• intranasal administration of the formulation also showed better permeation in ex vivo studies with goat nasal mucosa and higher drug concentration in the brain in in vivo studies with Wistar rats compared to plain cannabidiol [116]. Hybrid nanoparticles Each NP class represents exclusive advantages for