Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

• developed. Cell-penetrating peptides (CPPs), renowned for their ability to traverse biological membranes, have been extensively studied for their potential to enhance endosomal escape by causing membrane disruption [5]. However, the broad utility of CPPs is limited by their non-specific nature, which often

Bioselectivity of silk protein-based materials and their bio-inspired applications

• Hendrik Bargel,
• Vanessa T. Trossmann,
• Christoph Sommer and
• Thomas Scheibel

Beilstein J. Nanotechnol. 2022, 13, 902–921, doi:10.3762/bjnano.13.81

• and promotes their attachment to the bacterial surface/membrane residues [85]. HDPs have properties of cell-penetrating peptides and can translocate across membranes of prokaryotic, but also eukaryotic, cells [90]. The main mode of action of these peptides is promotion of adhesion through the cationic

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• crossing through AMT by increasing the positive charge on the nanoparticle surface [125]. Another investigated way to increase BBB permeation is to use cell-penetrating peptides (CPPs). These peptides usually contain between five and 40 amino acids, including a large amount of basic amino-acid residues

• system was able to cross the BBB and to accumulate in glioma cells, thus improving the cytotoxicity effect of doxorubicin. To cross the BBB and to target glioma cells, liposomes have also been conjugated with cell-penetrating peptides. For example, in a study by Liu et al., a novel dual receptor

Internalization mechanisms of cell-penetrating peptides

• Ivana Ruseska and
• Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

• are dethroning small molecules as leading therapeutics. Given their immense potential, they are highly sought after. However, their application is limited mostly due to their poor in vivo stability, limited cellular uptake and insufficient target specificity. Cell-penetrating peptides (CPPs) represent

• influence the cellular uptake mechanism. Keywords: cell-penetrating peptides; direct translocation; drug delivery; endocytosis; internalization; Introduction The cell membrane is a semipermeable barrier, serving as a protective layer for the cells. It is an essential organelle for cell survival and

• provide enzymatic protection and stability for the drug, an improved distribution and target specificity, as well as a lack of toxicity [3]. Cell-penetrating peptides as drug delivery systems Having in mind the attention they have gained, cell-penetrating peptides (CPPs) have become a current hotspot in

In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

• Moritz Nazarenus,
• Qian Zhang,
• Mahmoud G. Soliman,
• Pablo del Pino,
• Beatriz Pelaz,
• Susana Carregal-Romero,
• Joanna Rejman,
• Barbara Rothen-Rutishauser,
• Martin J. D. Clift,
• Reinhard Zellner,
• G. Ulrich Nienhaus,
• James B. Delehanty,
• Igor L. Medintz and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1477–1490, doi:10.3762/bjnano.5.161

• release from the intracellular vesicles to the cytosol [56][57][58] (and not the diffusion through (transient) membrane pores). Endosomal release is, for example, a scenario which has been unraveled in detail for NPs coated with certain cell penetrating peptides (CPPs) [59][60][61][62]. Thus, while NPs