Facile synthesis of platinated DNA nanoparticles with radiosensitizing potential

• Leo Sala,
• Tomas Perecko,
• Antonín Kaňa and
• Jaroslav Kočišek

Beilstein J. Nanotechnol. 2026, 17, 1117–1127, doi:10.3762/bjnano.17.76

• atoms per nucleotide. The nanoparticles showed high thermal stability with the onset of thermal degradation between 80 and 90 °C and remained structurally stable at 4 °C storage for months. Clonogenic assays in FaDu cells demonstrated radiosensitization, with a dose enhancement ratio of 1.17 ± 0.07 at

• payload and a stabilizing cross-linker that reinforces the DNA matrix [24]. Beyond its conventional role in chemotherapy, cisplatin acts as a potent radiosensitizer [25][26] by reacting with low-energy secondary electrons generated during radiotherapy to amplify DNA damage within tumor cells [27][28

• with Milli-Q water (Millipore, USA). Clonogenic assay FaDu (#305033, squamous cell carcinoma of the hypopharynx) cell line was acquired from Cytion (Germany). Cells were cultured in RPMI-1640 medium (#21875‑091, Gibco, USA) supplemented with 10% FBS (#10270106, Gibco, USA) and 1% penicillin

Synthesis of carbon dot-mediated gold nanostructures: experimental and quantum chemical insights into turn-on fluorescence sensing of N-acetylcysteine

• Thuy-Huong Nguyen,
• Van-Nghia Nguyen,
• Ha Thi Thu Nguyen,
• Ha Ngoc Nguyen,
• Anh Duc Nguyen,
• Tuyen Viet Nguyen and
• Truong Xuan Nguyen

Beilstein J. Nanotechnol. 2026, 17, 1103–1116, doi:10.3762/bjnano.17.75

• , and –COOH. The model consists of 54 atoms, with edge carbon atoms hydrogen-passivated to satisfy valence requirements. All systems were modeled under periodic boundary conditions using sufficiently large simulation cells to avoid interactions between periodic images. Owing to the presence of acidic

Breaking barriers: nanosystems to overcome solubility and permeability challenges of second-generation tyrosine kinase inhibitors

• Bhagya Shree,
• Abhishek Sharma,
• Manish Kumar,
• Ruchi Chawla and
• Brahmeshwar Mishra

Beilstein J. Nanotechnol. 2026, 17, 1063–1086, doi:10.3762/bjnano.17.73

• in non-tumorigenic human embryonic kidney cells (HEK-293) and MCF10A cell lines, supporting the safety and potential applicability of this delivery system [41]. Hence, polymeric nanoparticles are versatile carriers that improve the therapeutic performance of TKIs by enabling targeted delivery

• packed-bed reactors demonstrated, respectively, 1.63 and 1.35 times improved in vitro drug permeability compared to raw DTB and cytotoxicities of 30.08% and 22.33% vs 11.51% in M.D. Anderson metastatic breast cancer – 231 (MDA-MB-231) cells [45]. Likewise, DTB nanocrystals prepared by sonoprecipitation

• -231 cells [75]. Hyaluronic acid-conjugated and curcumin TPGS were employed to formulate pH-sensitive micelles for the delivery of DTB to tumour cells. These nanoparticles exhibited enhanced drug release under acidic conditions characteristic of the tumour microenvironment and demonstrated good in

Nanoglasses: a trail towards uncharted regions of vitreous materials and their properties?

• Gerhard Wilde and
• Horst Hahn

Beilstein J. Nanotechnol. 2026, 17, 1047–1062, doi:10.3762/bjnano.17.72

Influence of an external electric field on the catalytic CO oxidation of nanoscaled CeO₂ and its La³⁺ and Gd³⁺ congeners

• Parastoo Jamshidi,
• Silvio Heinschke and
• Jörg J. Schneider

Beilstein J. Nanotechnol. 2026, 17, 1028–1038, doi:10.3762/bjnano.17.70

• the efficiency of CO oxidation [1]. The potential applicability of CeO2 in this reaction as well as in photocatalysis, gas sensing, solar cells, electrocatalysis, and as ultraviolet absorbent has been investigated extensively [2]. CeO2 crystallizes in the fluorite crystal structure in which each Ce4

Synthesis and characterization of RF-sputtered ZnTe/Cu_2−xTe thin films for solar cell applications

• Gerardo Arreola Jardón,
• Susana Meraz Dávila,
• Claudia Elena Pérez García,
• Aime Margarita Gutiérrez Peralta and
• Sergio Joaquín Jiménez Sandoval

Beilstein J. Nanotechnol. 2026, 17, 1016–1027, doi:10.3762/bjnano.17.69

• incorporation and the formation of conductive Cu-rich secondary phases, yielding a biphasic system composed of semiconducting ZnTe and conductive Cu-rich telluride phases. These material properties suggest potential relevance for future studies of back-contact materials in CdTe-based solar cells. Keywords

• : back contact materials; Cu2−xTe phases; phase segregation; RF magnetron sputtering; ZnTe thin films; Introduction CdTe solar cells remain one of the leading thin-film photovoltaic technologies due to the near-optimal direct bandgap of CdTe (≈1.45 eV) and its high absorption coefficient (>104 cm−1

• challenges for large-scale application [4]. One of the most persistent limitations in CdTe solar cells is the formation of a stable back contact with low resistance. The high work function of CdTe (≈5.7 eV) and its relatively high surface resistivity hinder the formation of an ideal ohmic contact with

Ultrasonic irradiation in the synthesis of nanohydroxyapatite: a chemically friendly technique for improving hemocompatibility and antibiofilm applications

• Juan Mendoza Turmero,
• Cristina Parra Pantoja,
• Marcos Sabino Gutiérrez,
• Milagro Fernández-Delgado,
• Claudia Alvarado-Castillo,
• Damarys Soto Gil,
• María E. Gomes Gomes,
• Yony Gutiérrez Barrios and
• Daniel Suárez Arteaga

Beilstein J. Nanotechnol. 2026, 17, 991–1015, doi:10.3762/bjnano.17.68

• its ability to form virulent biofilms, which are particularly difficult to eradicate. Biofilms are communities of microbial cells enclosed by exopolysaccharides that adhere to inert or living surfaces. These biofilms enhance bacterial growth and survival by providing access to nutrients and protection

• hemolysis values are comparable to those of other hydroxyapatites. For example, Barbosa et al. [85] using washed mouse red blood cells reported less than 2% hemolysis for hydroxyapatite tested up to 1 mg/mL for 1 h; and Radha et al. [86] using washed human red blood cells reported less than 2% of hemolysis

• to erroneous results [87]. In this sense, the sonochemical synthesis used to obtain nHA in this research, is simple and chemically clean, aligning with the principles of green chemistry. Figure 10 shows optical microscopy images of red blood cells from the bottom of the remaining fraction from which

Development of Protium heptaphyllum essential oil-loaded nanocapsules: experimental design and biological activity

• Debora Freitas Silva,
• Kaidy Giselle Orellana,
• Allessya Lara Dantas Formiga,
• Jin Wang,
• Eloisa Helena de Aguiar Andrade,
• Aline Collares Valente Pinheiro,
• Maria Izabel de Jesus,
• Francisco Canindé Ferreira de Luna,
• Wallax Augusto Silva Ferreira,
• Edivaldo Herculano Correa de Oliveira,
• Francisco Humberto Xavier Junior,
• Emmanuel Abraham Ho and
• Marcele Fonseca Passos

Beilstein J. Nanotechnol. 2026, 17, 974–990, doi:10.3762/bjnano.17.67

• ± 0.04, a zeta potential of −25.49 ± 1.08 mV and an encapsulation efficiency above 99%, in addition to long-term colloidal stability. Cell viability assays in HaCaT cells showed high biocompatibility, with cell viability above 70% up to 6 mg/mL and only moderate toxicity at 12 mg/mL. In antimicrobial

• storage [45]. Cell viability The cell viability following treatment with NPNC (Figure 4) showed a clear dose-dependent effect, with higher concentrations of encapsulated oil reducing viability in immortalized human keratinocyte epithelial cells (HaCat). At 12 mg/mL, a marked decrease was observed

• . Additionally, the effective concentration remains within a biologically safe range, as demonstrated in HaCaT cells, ensuring antimicrobial activity without compromising cell viability. Taken together, these findings provide evidence that the nanocapsule system enhances the antibacterial efficiency of P

Materials challenges in solid-state sensors for continuous monitoring of ions in water

• Maryam Darestani-Farahani and
• Peter Kruse

Beilstein J. Nanotechnol. 2026, 17, 935–973, doi:10.3762/bjnano.17.66

Nanocarrier strategies to overcome P-glycoprotein-mediated drug resistance in cancer therapy

• Andreina Quevedo-Enríquez,
• Katty Yi Zhang,
• Denisse Yajaira Enriquez,
• Byron Raul Inapanta,
• Roxana Noemí Peroni and
• Christian Rafael Quijia

Beilstein J. Nanotechnol. 2026, 17, 882–921, doi:10.3762/bjnano.17.64

• compromised by multidrug resistance (MDR), a phenomenon in which cancer cells evade the cytotoxic effects of drugs through various mechanisms. Overexpression of efflux transporters, particularly P-glycoprotein (P-gp), is a well-documented contributor to this phenotype, although it is not the sole mechanism

• by uncontrolled proliferation of breast tissue cells and marked clinical heterogeneity. Among the resistance mechanisms documented in breast cancer, overexpression of P-gp has been studied extensively as a factor that actively exports chemotherapeutic agents from cancer cells, reducing intracellular

• restoring drug sensitivity [10]. 1.2 Mechanisms of multidrug resistance in cancer Multidrug resistance and metastasis are the main causes of cancer treatment failure. MDR tends to occur in cancer patients and is the ability of tumor cells to develop a specific mechanism to resist and overcome the cytotoxic

Nanoparticle delivery systems for HIV pre-exposure prophylaxis (PrEP): advances and challenges

• Sonia Zahara and
• Björn M. Reinhard

Beilstein J. Nanotechnol. 2026, 17, 839–853, doi:10.3762/bjnano.17.60

• for the nanoparticles’ ability to target specific tissues and cells. CD4+ T cells and antigen-presenting cells of myeloid lineage, such as macrophages or dendritic cells (DCs), are involved in HIV infection and are, therefore, cellular targets of interest. CD4+ T cells are the primary host cells of

• HIV in cis-infection, in which the virus directly binds to a host cell and initiates replication [30], whereas myeloid cells play a role in trans-infection [31][32][33]. In trans-infection, the virus binds to myeloid cells via a myeloid-cell receptor, in particular sialic acid-binding Ig-like lectin 1

• combination of TDF/FTC as nucleoside reverse transcriptase inhibitors (NRTIs) or long-acting injectable CAB as integrase strand transfer inhibitor (INSTI) [2][15][16]. Targeting cells relevant for both cis- and trans-infection through appropriate nanoparticle delivery strategies is of interest for enhancing

Glycerol photoelectrochemical oxidation reaction at carbon nitrides/BiVO₄ materials

• Charles Garcia da Cunha,
• Isabelle M. D. Gonzaga,
• Cristian Hessel,
• Izadora F. Reis,
• Ivo F. Teixeira,
• Lucia H. Mascaro and
• Elton Sitta

Beilstein J. Nanotechnol. 2026, 17, 806–817, doi:10.3762/bjnano.17.57

• ; bismuth vanadate; glycerol valorization; heterojunctions; photoelectrochemistry; Introduction Hydrogen production based on sustainable and renewable energy sources (the so-called green-H2) is a promising alternative for energy storage, with potential applications in fuel cells and the chemical industry

• context, the oxidation of small organic molecules has great potential to replace water oxidation in photoelectrochemical cells [22], as these molecules have a considerably lower standard potential, with the possibility to yield value-added products. Indeed, biomass derivatives, such as ethanol and

• glycerol, are targeted to become a new route for converting solar energy into fuels [23] at both sides of the cells (i.e., while H2 is produced at the cathode, carboxylic acids, aldehydes, and ketones can be produced at the anode [24]). It is expected that glycerol photoelectrochemical oxidation at BiVO4

Restorative potential of laser-synthesized silver nanoparticles with Salvia officinalis for periodontal disease treatment: an in vitro study

• Jelena Filipović Tričković,
• Sanja Živković,
• Bojana Ilić,
• Miloš Tošić,
• Jelena Marinković,
• Ana Valenta Šobot and
• Miloš Momčilović

Beilstein J. Nanotechnol. 2026, 17, 781–795, doi:10.3762/bjnano.17.55

• aqueous sage extract as a stabilizer has not been reported. In the work conducted by Déné and co-workers [8], antifungal properties of sage-synthesized AgNPs were reported; but neither antibacterial effects nor effects on the eukaryotic cells were evaluated, and the synthesis relied on a chemical approach

• the 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay according to the standard procedures [27]. Upon seeding in 24-well plates at a density of 0.05 × 106 and reaching the subconfluent level, the cells were treated with concentrations of 0.5 × MIC, 1 × MIC, and 2

• × MIC for 24 and 48 h. Absorbance was measured at 470 nm on a microplate reader (Sunrise, Tecan Group Ltd., Switzerland). The results are presented as the percentage of viable cells compared to the untreated control (100% of viable cells). Cell proliferation assay Ki-67 immunofluorescent staining was

Interface-engineered Caco-2 cell culture on a collagen-coated liquid–liquid interface in a microfluidic device

• Satoru Kuriu and
• Soo Hyeon Kim

Beilstein J. Nanotechnol. 2026, 17, 760–768, doi:10.3762/bjnano.17.53

• Caco-2 cells in the device, we show that the liquid interface supports cell attachment and the formation of monolayers. Immunofluorescence observation reveals the development of tight junctions and organized actin cytoskeletons, indicating early-stage epithelial maturation. Our new microfluidic system

• Epithelial tissues form selective barriers that regulate the transport of molecules, ions, and gases; they play an important role in physiological homeostasis [1]. In vitro models of epithelial barriers, particularly culturing Caco-2 cells, have been widely used to study the function of the epithelial

• tissues [2][3][4]. The microfluidic culture system known as gut-on-a-chip enables the cultivation of Caco-2 cells under conditions that more closely recapitulate the in vivo intestinal environment. By precisely controlling fluid flow and inducing mechanical stimuli, this platform provides physiologically

Environmental applications of silver nanoparticles: state-of-the-art review and emerging trends

• Soni Prajapati,
• Akash Kumar and
• Ranjana Singh

Beilstein J. Nanotechnol. 2026, 17, 697–736, doi:10.3762/bjnano.17.49

• safety evaluation. Nanosilver coated with tannic acid significantly inhibits adenovirus type 3 (Ad3) in HeLa cells, serving as a model system [78]. The inhibition mechanism involves structural and DNA damage to Ad3 [78]. Another study assessed the dose- and size-dependent antiviral effects of AgNPs

Molecular engineering of individual dye-based nanoparticle photostability for ultrabright two-photon fluorescence

• Eleonore Kurek,
• Sasha Cooper,
• Alexandre Clausolles,
• Karen Perronet,
• Jonathan Daniel,
• Mireille Blanchard-Desce and
• François Marquier

Beilstein J. Nanotechnol. 2026, 17, 688–696, doi:10.3762/bjnano.17.48

• bioactuators for drug delivery [6][7][8][9], and most recently as actuators for optogenetics in mice [10]. However, dFONs are most widely used as biomarkers for fluorescence imaging. Their stealth properties can be engineered as needed [11][12][13][14], making them versatile for use in cells, tissues [15] and

• whole animals, such as Xenopus tadpoles [3], zebrafish [16][17], and mice [15]. Furthermore, dFONs have proven highly effective as probes for single-particle tracking (SPT) experiments, both within cells [18][19] and deep in the extracellular space of the mouse brain [20]. Recently, we achieved a

• practice is to assess the overall photostability of the nanoparticles in solution [16][17][29][30] or in cells [15][29], by monitoring the fluorescence intensity under continuous illumination. These studies effectively demonstrate the superior photostability of dFONs compared to individual organic dye

Two-step laser synthesis of Ag@TiO₂ nanomaterials for the photocatalytic degradation of rhodamine B

• Marija Kovačević,
• Miloš Tošić,
• Rafaela Radičić,
• Vladimir Rajić,
• Nikša Krstulović,
• Miloš Momčilović and
• Sanja Živković

Beilstein J. Nanotechnol. 2026, 17, 622–634, doi:10.3762/bjnano.17.43

• electrophoretic mobility Hydrodynamic size distribution and zeta potential of the nanoparticles were measured using a Zetasizer Ultra (Malvern Panalytical, Malvern, Worcestershire, UK). Disposable plastic cuvettes were employed for size distribution analysis, while capillary cells were used for zeta potential and

Recent progress in enhancing built-in electric fields of perovskite solar cells via junction engineering

• Tong Xiao and
• Ke Xu

Beilstein J. Nanotechnol. 2026, 17, 602–621, doi:10.3762/bjnano.17.42

• Tong Xiao Ke Xu School of Electrical & Control Engineering, Shenyang Jianzhu University, Shenyang, China 10.3762/bjnano.17.42 Abstract The performance of perovskite solar cells (PSCs) is primarily governed by the built-in electric field (BEF), which dictates photocarrier separation, drift

• ; junction; perovskite solar cells; Introduction Driven by the global push for carbon neutrality, next-generation high-efficiency and low-cost photovoltaic technologies have gained increasing attention. Due to their high absorption coefficients, long carrier diffusion lengths, tunable bandgaps, and solution

• processability, perovskite solar cells (PSCs) have advanced significantly since their inception [1]. The power conversion efficiency (PCE) of single-junction devices has risen from 3.8% to 27.3% [2][3][4], highlighting their potential to approach the Shockley–Queisser limit. In typical heterojunction solar cells

Towards targeted drugs and next generation of nanomedicines

• Anna Salvati,
• Silvia Giordani and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2026, 17, 598–601, doi:10.3762/bjnano.17.41

• size in a "big" human. At the same time, recent findings suggested that nanoparticles may be able to reach tumor tissue also via active mechanisms of uptake and transport across tumor endothelial cells, potentially opening up new ways to reach tumors with drugs [20][21][22]. Next to passive targeting

• , active targeting strategies are also being investigated, where drugs and drug carriers are modified via the addition of ligands specifically recognizing receptors overexpressed at the targeted cells. While few antibody–drug conjugates have been approved for clinical use [23], active targeting still

• several reviews on the current development of specific classes of nanomaterials, nanomedicines applied to specific diseases, and fundamental understanding of how nanomedicines are processed by cells and in the body. As a conclusion one can say that nanomedicine is in its infancy steps, where first

Impacts of annealing on structural and photophysical properties of zinc phthalocyanine adsorbed on graphene

• Gautier Creutzer,
• Quentin Fernez,
• Nataliya Kalashnyk,
• Zohreh Safarzadeh,
• Lydia Sosa Vargas,
• Céline Fiorini-Debuisschert,
• Nicolas Fabre and
• Fabrice Charra

Beilstein J. Nanotechnol. 2026, 17, 576–585, doi:10.3762/bjnano.17.39

• a promising route to design original and innovative electronic devices [1] such as diodes [2][3], transistors [4][5][6], photodetectors [7][8], solar cells [9][10][11], or light-emitting devices [12]. In such heterostructures most electronic processes take place at the interface between graphene and

Laser–material interactions in liquids for the synthesis of nanomaterials: current status and perspectives

• Carlos Doñate Buendia,
• Bilal Gökce and
• Leonid V. Zhigilei

Beilstein J. Nanotechnol. 2026, 17, 571–575, doi:10.3762/bjnano.17.38

• ]), generation of soft magnets for magnetocaloric applications [58], fabrication of photodetectors [59], nanoscale agents for photodynamic [60] and neutron capture therapy [61], incorporation of nanoparticles into solar cells [62], light-harvesting nanofluids [63], and materials with enhanced mechanical [64] or

Advances in nanotechnology applied to natural products

• Douglas Dourado,
• Fábio Rocha Formiga,
• Éverton do Nascimento Alencar and
• Franceline Reynaud

Beilstein J. Nanotechnol. 2026, 17, 555–558, doi:10.3762/bjnano.17.36

• applications, including cancer therapy, where they may be designed as conventional liposomes or as immunoliposomes functionalized with antibodies or ligands to promote targeted delivery to tumor cells or components of the immune microenvironment [18]. Combining liposomes with natural products and co-loaded

Defects and defect-mediated engineering of two-dimensional materials: challenges and open questions

• Arkady V. Krasheninnikov,
• Matthias Batzill,
• Anouar-Akacha Delenda,
• Marija Drndić,
• Chris Ewels,
• Katharina J. Franke,
• Mahdi Ghorbani-Asl,
• Alexander Holleitner,
• Ado Jorio,
• Ute Kaiser,
• Daria Kieczka,
• Hannu-Pekka Komsa,
• Jani Kotakoski,
• Manuel Längle,
• David Lamprecht,
• Yun Liu,
• Steven G. Louie,
• Janina Maultzsch,
• Thomas Michely,
• Katherine Milton,
• Anna Niggas,
• Hanako Okuno,
• Joshua A. Robinson,
• Marika Schleberger,
• Bruno Schuler,
• Alexander Shluger,
• Kazu Suenaga,
• Kristian S. Thygesen,
• Richard A. Wilhelm,
• E. Harriet Åhlgren and
• Carla Bittencourt

Beilstein J. Nanotechnol. 2026, 17, 454–488, doi:10.3762/bjnano.17.31

Nanocarrier-integrated multilayer films produced by 3D printing for improved skin adhesion and curcumin photostability

• Thayse Viana de Oliveira,
• Ana Paula Farias Leão,
• Júlia Leão,
• Cesar Liberato Petzhold and
• Ruy Carlos Ruver Beck

Beilstein J. Nanotechnol. 2026, 17, 440–453, doi:10.3762/bjnano.17.30

• to test our central hypothesis that multilayer printing can provide enhanced bioadhesion and light protection. However, they will be crucial for future optimisation and translation, including in vitro release testing using Franz diffusion cells as well as skin permeation studies. Conclusion In this

First-principles study on elastic properties of Cu, (Cu_1−x,Ni_x)₃Sn and interfacial mechanical properties of (Cu_1−x,Ni_x)₃Sn/Cu in the lead-free solder joint

• Guomin Hua

Beilstein J. Nanotechnol. 2026, 17, 428–439, doi:10.3762/bjnano.17.29

• calculated the energy increments of the deformed cells. Via quadratic fits of the relation between the energy increments and the strains, the elastic constants C11, C12, and C44 for Cu and C11, C22, C33, C12, C13, C23, C44, C55, and C66 for (CuxNi1−x)3Sn were extracted. Based on the calculated elastic