Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

• Thi Ngoc Han Pham,
• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan Thang Cao,
• Thanh-Danh Nguyen,
• Vy Tran Anh and
• Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

• chemotherapeutic agent chlorambucil (CHL) and the imaging agent IR780. The approach in this study incorporates Pluronic F127-folate onto the PLGA nanoparticles, which enables targeted delivery to folate receptor-expressing cancer cells. The F127-folate@PLGA/CHL/IR780 nanoparticles were formulated using a

• and diagnosis, leveraging the advantages of PLGA, folate targeting, and the integration of therapeutic and imaging agents. Keywords: cancer; chlorambucil; drug carrier; IR780; PLGA nanoparticle; theragnostic; Introduction Poly(ᴅ,ʟ-lactic-co-glycolic acid) (PLGA), a copolymer of poly(lactic acid

• folic acid to enhance the imaging contrast in magnetic resonance imaging (MRI) or to improve the therapeutic efficacy of nanoparticles [14]. Chlorambucil (CHL) is a nitrogen mustard alkylating drug used to treat several benign tumors and malignancies, including chronic lymphatic leukemia [15], Hodgkin’s

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan-Thang Cao,
• Vy Tran-Anh and
• Hieu Vu Quang

Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17

• nanocarrier that can be loaded with the chemotherapeutic medication chlorambucil and magnetic resonance imaging agents (e.g., iron oxide nanoparticles and near-infrared fluorophore IR780) for theragnostics. Poly(lactic-co-glycolic acid) was combined with the aforementioned ingredients to generate poly(vinyl

• alcohol)-based nanoparticles (NPs) using the single emulsion technique. Then the NPs were coated with F127 and F127-folate by simple incubation for five days. The nanoparticles have the hydrodynamic size of approx. 250 nm with negative charge. Similar to chlorambucil and IR780, iron oxide loadings were

• observed for all three kinds of NPs. The release of chlorambucil was quicker at pH 5.4 than at pH 7.4 at 37 °C. The F127@NPs and F127-folate@NPs demonstrated much greater cell uptake and toxicity up to 72 h after incubation. Our in vitro results of F127@NPs and F127-folate@NPs have demonstrated the ability

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

• Makoto Komiyama

Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21

• recent topics on medical applications of CyD 6.1 Chemical modification of CyD for precise targeting to predetermined cells A multicharged nanoassembly was constructed from β-CyD bearing seven hexylimidazolium units, adamantane-grafted hyaluronic acid, and chlorambucil (an anticancer drug) [90]. In cancer

• efficacy of chlorambucil was greatly increased since it remained in the cell for a long time. Furthermore, an anticancer drug and a resistance-suppressing gene were simultaneously delivered for cooperation [91]. For delayed drug release, anionic β-CyD polymers bearing carboxylate residues are useful [92

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• decreased without enhancing the risk of skin damage [131]. It has been established that ADV-mediated delivery of several chemotherapeutic drugs, including DOX [132], paclitaxel [133], and chlorambucil, could be achieved when loaded into PFC droplets [134]. The NDs could be successfully accumulated in a