Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• (i.e., IQN-iRGD-PLHNPs) to enhance anti-BC activity by active tumor targeting [121]. Coumarin-6 was tagged with the nanocarrier to investigate the cellular uptake potential. The developed targeted PLHNPs represented markedly enhanced cell uptake in MDA-MB-231 due to integrin receptor-mediated

Mn-doped ZnO nanopowders prepared by sol–gel and microwave-assisted sol–gel methods and their photocatalytic properties

• Cristina Maria Vlăduț,
• Crina Anastasescu,
• Silviu Preda,
• Oana Catalina Mocioiu,
• Simona Petrescu,
• Jeanina Pandele-Cusu,
• Dana Culita,
• Veronica Bratan,
• Ioan Balint and
• Maria Zaharescu

Beilstein J. Nanotechnol. 2024, 15, 1283–1296, doi:10.3762/bjnano.15.104

• fluorescent compound, namely umbelliferone, a coumarin degradation product obtained in the presence of hydroxyl radicals. Figure 11a–c clearly shows that ·OH radicals are photogenerated to a greater extent by the MW catalyst. This could be the result of specific differences in surface chemistry of the two

• resolution of 0.5 nm, and 10 nm slits in excitation and emission. All measurements were performed for 0.001 g catalyst suspended after ultrasonication in ultrapure water at room temperature (25 °C) and λexc = 270 nm. For ROS identification, ·OH radicals trapping was performed with 10 mM coumarin solution

Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

• Thi Ngoc Han Pham,
• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan Thang Cao,
• Thanh-Danh Nguyen,
• Vy Tran Anh and
• Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

• ), dichloromethane (DCM), 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-2H-tetrazolium bromide (MTT) (M2128), coumarin-6 (Cou-6) (442631), folic acid (1039840005) and 1,1-carbonyldiimidazole (115533) were purchased from Sigma-Aldrich. Dulbecco’s Modified Eagle Medium (DMEM) (11965092), fetal bovine serum (FBS

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan-Thang Cao,
• Vy Tran-Anh and
• Hieu Vu Quang

Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17

• -127 (P2443), poly(vinyl alcohol) (PVA) (P8136), phosphate buffered saline (PBS) (P4417), dimethyl sulfoxide (DMSO) (472301), dichloromethane (DCM), 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl-2H-tetrazolium bromide (MTT) (M2128), and coumarin-6 (442631), K3[Fe(CN)6] (1049730100) were purchased from

• formulations of the three nanoparticles were F127-folate@PLGA/IO/CHL/IR780 (F127-folate@NP), F127@PLGA/IO/CHL/IR780 (F127@NP), and PVA@PLGA/IO/CHL/IR780 (PVA@NP). Coumarin-6 (0.2 mg) was added to the organic phase to create F127-folate@NP/Cou-6, F127@NP/Cou-6, and PVA@NP/Cou-6 for the fluorescence assay in

Titania nanoparticles for photocatalytic degradation of ethanol under simulated solar light

• Evghenii Goncearenco,
• Iuliana P. Morjan,
• Claudiu Teodor Fleaca,
• Florian Dumitrache,
• Elena Dutu,
• Monica Scarisoreanu,
• Valentin Serban Teodorescu,
• Alexandra Sandulescu,
• Crina Anastasescu and
• Ioan Balint

Beilstein J. Nanotechnol. 2023, 14, 616–630, doi:10.3762/bjnano.14.51

• compounds. For example, the hydroxyl radical (•OH) is a strong oxidizer. The generation of (•OH) over the samples under simulated solar light irradiation (AM 1.5) has been evaluated according to the PL emission from 451 nm, attributable to the presence of umbelliferone, a derivative of coumarin resulting

• well as the oxidation states were found from the XPS spectra by using the “Avantage” software, version 5.978. ROS identification Trapping of •OH radicals was performed with 10 mM coumarin (Merck) solution and 0.001 g suspended catalyst exposed to simulated solar irradiation. The formation of a

Self-assembly and spectroscopic fingerprints of photoactive pyrenyl tectons on hBN/Cu(111)

• Domenik M. Zimmermann,
• Knud Seufert,
• Luka Ðorđević,
• Tobias Hoh,
• Sushobhan Joshi,
• Tomas Marangoni,
• Davide Bonifazi and
• Willi Auwärter

Beilstein J. Nanotechnol. 2020, 11, 1470–1483, doi:10.3762/bjnano.11.130

• excitation of the low-energy absorption peak lead to a strong emission at 433 and 458 nm (2.86 and 2.71 eV), with a quantum yield of 96% (determined using coumarin 153 in an EtOH solution as a reference). As expected, the tetrasubstituted pyrene 1 showed electronic transitions that were bathochromically

• lifetime measurements were performed on a JobinYvon-Horiba FluoroHub single-photon-counting module, using nano-LED-pulsed sources at 295 or 372 nm. The quantum yield measurements were performed using the relative determination, with coumarin 153 (C153, ϕ = 0.53 in ethanol) as the standard (st) [87]. The

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• both formulations were able to cross the BBB and deliver their cargo. On the other hand, in another study, coumarin-6-loaded PLGA nanoparticles coated with either chitosan or PS80 showed a better crossing ability than P188-coated nanoparticles [57]. This result seems to be in accordance with the

• cationic bovine serum albumin (CBSA) allows them to cross the BBB by AMT, as described above [110][111][112][114]. PEG-PLA nanoparticles were labeled with coumarin-6 and conjugated with either CBSA or BSA in a study by Lu and co-workers [110]. Transcytosis assays were performed on a co-culture BBB in vitro

• model and showed that CBSA-nanoparticles had an apparent permeability (Pe) seven times higher than that of BSA-nanoparticles. Furthermore, a leaching study of coumarin-6 was performed at pH 4.0 and 7.4 and showed that less than 1% of the dye was released from the nanoparticles after 80 h. Thus, coumarin

Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting

• Xianping Liu,
• Chengjuan Du,
• Haichun Li,
• Ting Jiang,
• Zimiao Luo,
• Zhiqing Pang,
• Daoying Geng and
• Jun Zhang

Beilstein J. Nanotechnol. 2019, 10, 1860–1872, doi:10.3762/bjnano.10.181

• was purchased from Abcam (USA). mPEG-DSPE (MW = 2000) and DSPE-PEG-NH2 (MW = 3400) was purchased from Laysan Bio (USA). DSPE-PEG-NHS (MW = 2000) was obtained from Nanocs (USA). DAPI (2-(4-amidinophenyl)-1H-indole-6-carboxamidine) was obtained from Beyotime (Nantong, China). Coumarin-6 was bought from

• derivative. Briefly, Cy7.5/DSPE-PEG-NH2 2:1 was dissolved in 10 mL of anhydrous dichloromethane and then reacted for 30 min. Then, the combination was evaporated with a ZX-98 rotary evaporator (Shanghai Institute of Organic Chemistry, China) for 1 h at room temperature. Cy7.5- and coumarin-6-decorated PEG

• -SPION (labeled as NPs in this work) were prepared in line with an adapted procedure previously described [27]. In brief, 2 mg of SPIONs, 10 mg of mPEG-DSPE, 1 mg of DSPE-PEG-NHS, 1 μg coumarin-6 and 0.5 mg DSPE-PEG-Cy7.5 were combined in 10 mL of dichloromethane and sonicated (53 W) for 10 min at room

Comparing a porphyrin- and a coumarin-based dye adsorbed on NiO(001)

• Sara Freund,
• Antoine Hinaut,
• Nathalie Marinakis,
• Edwin C. Constable,
• Ernst Meyer,
• Catherine E. Housecroft and
• Thilo Glatzel

Beilstein J. Nanotechnol. 2019, 10, 874–881, doi:10.3762/bjnano.10.88

• technologies such as dye-sensitized solar cells. A key optimization parameter for such devices is the choice of the compounds in order to control the direction and the intensity of charge transfer across the interface. Here, the deposition of two different molecular dyes, porphyrin and coumarin, as single

• Kelvin probe force microscopy measurements. Keywords: coumarin; Kelvin probe force microscopy; metal oxide; molecular resolution; nickel oxide (NiO); non-contact atomic force microscopy; porphyrin; Introduction With regard to its use in dye-sensitized solar cells (DSSCs), the wide-bandgap n-type

• -carboxyphenyl)porphyrin (Cu-TCPP) has been studied for the fabrication of n-type DSSCs [21][22]. In contrast, Coumarin 343 (C343) is an electron acceptor and is used for the design of p-type devices [23][24]. Both molecules structures are shown in Figure 1b. In this paper, non-contact atomic force microscopy

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

• Maria J. Ramalho,
• Joana A. Loureiro,
• Bárbara Gomes,
• Manuela F. Frasco,
• Manuel A. N. Coelho and
• M. Carmo Pereira

Beilstein J. Nanotechnol. 2015, 6, 1306–1318, doi:10.3762/bjnano.6.135

• conclude that nanoencapsulation in PLGA NPs may offer a new and potentially effective administration strategy of calcitriol that overcomes the actual limitations such as its low bioavailability. Experimental Chemicals PLGA Resomer® RG503H (50:50; Mw 24,000–38,000), ethyl acetate, Pluronic®F127, coumarin-6

• and subcultured. PLGA nanoparticle preparation PLGA NPs were prepared using the single emulsion solvent evaporation technique. For that purpose, 10 mg of PLGA was dissolved in 0.1 mL of ethyl acetate, and for encapsulation, 1 mg of vitamin was added. PLGA NPs for the entrapment of coumarin-6 were also

• prepared by this method using 1% w/w of coumarin-6 (C6). 200 μL of an aqueous solution of 1% w/v Pluronic®F127 was added dropwise to the organic phase. Then, the solution was vortexed and emulsified by sonication at an ultrasonic frequency of 45 kHz. The emulsion was subsequently poured into 2.5 mL of 0.1

Donor–acceptor graphene-based hybrid materials facilitating photo-induced electron-transfer reactions

• Anastasios Stergiou,
• Georgia Pagona and
• Nikos Tagmatarchis

Beilstein J. Nanotechnol. 2014, 5, 1580–1589, doi:10.3762/bjnano.5.170

• demonstrates the usage of a GO–coumarin conjugate as an activated fluorescent imaging probe with high sensitivity in the visualization of cancer cells [54]. The fluorescence of the probe can be switched off or on during intracellular imaging. Normally, the probe shows no or weak fluorescence (off) due to the

• fluorescence quenching of the coumarin moiety. However, fluorescence is activated (on) and significantly enhanced inside the cells by glutathione-initiated dissociation. Donor–acceptor hybrids based on exfoliated graphene However, as mentioned earlier, the surface defects in the sp2-network of GO influence the

Highly efficient ZnO/Au Schottky barrier dye-sensitized solar cells: Role of gold nanoparticles on the charge-transfer process

• Tanujjal Bora,
• Htet H. Kyaw,
• Soumik Sarkar,
• Samir K. Pal and
• Joydeep Dutta

Beilstein J. Nanotechnol. 2011, 2, 681–690, doi:10.3762/bjnano.2.73

• experiments, dye N719 was replaced by a fluorescent dye, namely Coumarin 343 (C343). Similar to dye N719, the carboxylic group of C343 binds directly to the Zn atoms on the surface of the ZnO nanorods [28] and has been used in DSSC applications [29][30]. The steady-state photoluminescence (PL) spectra of the

• -nanocomposite DSSC. Time-correlated single-photon count spectroscopic studies were conducted by using fluorescent Coumarin 343 dye, to explain the observed improvement in the DSSC performance in the presence of Au nanoparticles in the ZnO-nanorod photoelectrode. The results showed a longer decay time of the

• fluorescence study For the fluorescence study, nanorod thin films of ZnO and ZnO/Au were prepared on quartz glass substrate and the dye N719 was replaced with a fluorescent dye Coumarin 343 (C343, Aldrich), since N719 is nonfluorescent in nature. A 2 mM ethanolic solution of C343 dye was prepared and the