Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• intranasal administration compared to the intravenous administration of the NP formulation (by a factor of 2.41) [108]. In another study, NLCs were designed and optimized by 32 full factorial design for the encapsulation of clozapine, an anti-schizophrenia drug suffering from low bioavailability after oral

Design and characterization of polymeric microneedles containing extracts of Brazilian green propolis

• Camila Felix Vecchi,
• Rafaela Said dos Santos,
• Jéssica Bassi da Silva and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2022, 13, 503–516, doi:10.3762/bjnano.13.42

• ethanolic or glycolic extracts of Brazilian green PRP. A 32 full-factorial design was utilized to determine the influence of P407 and PRP extract on the morphology and mechanical characteristics of MNs. They were characterized macroscopically, microscopically, and regarding size and texture, yielding an

• yielded more malleable structures. Previous studies have shown that films containing PVA and propylene glycol are more malleable due to the breaking of hydrogen bonds by the effect of propylene glycol [34]. The factorial design chosen allowed us to evaluate the characteristics of the formulations

• , resulting in a factorial design of 32, totaling nine formulations for each type of extract, rendering a total of 18 formulations (Table 5). Firstly, each polymer was dispersed separately. To PVA, 8 mL of purified water were added, and the mixture was heated and stirred until completely dispersed. The

Effect of electrospinning process variables on the size of polymer fibers and bead-on-string structures established with a 2³ factorial design

• Paulina Korycka,
• Adam Mirek,
• Katarzyna Kramek-Romanowska,
• Marcin Grzeczkowicz and
• Dorota Lewińska

Beilstein J. Nanotechnol. 2018, 9, 2466–2478, doi:10.3762/bjnano.9.231

• diameter of uniform and heterogeneous fibers (with and without bead-on-string structures) and the size of beads obtained during the electrospinning process. A 23 factorial design was performed to determine the influence of the following factors: electrical voltage, flow rate and dynamic viscosity of the

• poly(vinylpyrrolidone) ethanolic solution. Factorial design enables the analysis of the mathematical relationship between the chosen factors and the response with a minimum number of experiments. The factor having the most significant impact on the size of beaded fibers and beads was the solution

• to be obtained with expected features. Keywords: bead-on-string structure; electrospinning; factorial design; polymer fiber; Introduction Since the beginning of the 21st century, the interest in electrospinning processes has been growing constantly. The reason for this is the wide range of

Prediction of the mechanical properties of zeolite pellets for aerospace molecular decontamination applications

• Guillaume Rioland,
• Patrick Dutournié,
• Delphine Faye,
• T. Jean Daou and
• Joël Patarin

Beilstein J. Nanotechnol. 2016, 7, 1761–1771, doi:10.3762/bjnano.7.169

• factorial design (orthogonal) and a set of axial points identical to the central point except for one parameter (values outside the studied range) [28][31]. All the experimental tests are systematically repeated 3 times. To explore relationships between the studied function and the operating parameters a