PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• , particularly the pathways of anti-PEG antibody production and complement activation. Building on these understandings, functionalized PEG lipids are reviewed for ligand conjugation and targeted LNP delivery function. Promising alternatives to replace the benchmark PEG lipids are also systematically reviewed to

• properties of LNPs including particle size, surface charge, and encapsulation efficiency. Subsequent sections explore the roles of PEG lipids in modulating protein corona formation and cellular uptake. The latter parts highlight the potential of functionalized PEG lipids for targeted delivery and the

• effect on LNPs can also impede cellular uptake in various tissues [29][30][32]. To overcome this trade-off, the use of functionalized PEG lipids may be able to facilitate receptor-specific targeting while maintaining the protection to LNP surface [33]. Functionalized PEG lipids for ligand conjugation and

Mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) as multivalent lectin-binding nanomaterials

• Stefania Ordanini,
• Wanda Celentano,
• Anna Bernardi and
• Francesco Cellesi

Beilstein J. Nanotechnol. 2019, 10, 2192–2206, doi:10.3762/bjnano.10.212

• (lower panels) of the mannose-functionalized PEG-PCL copolymers. A) Kinetic profiles obtained for the synthesis of (A4-)PEG9-PCL1 and (A4-)PEG8-PCL2 copolymers. Reactions were conducted using CuBr/HMTETA as catalytic system, at 50 °C under nitrogen atmosphere. B) GPC chromatograms of PEG9-PCL1 and A4

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

• Qura Tul Ain,
• Samina Hyder Haq,
• Abeer Alshammari,
• Moudhi Abdullah Al-Mutlaq and
• Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

• ability of PEGylated GO (PEG-GO) to deliver proteins into cells [26]. In addition, functionalized PEG-GO has been used as a nano-carrier of photosensitizers and synergistic anticancer agents [27]. PEG-GO has been widely used in vivo studies. Li et al. demonstrated that PEG coating reduced the retention of

• nGO in organs including lung, liver, and spleen and promoted its clearance from these organs [28]. Zhang et al. treated a tumour with a chemo-photothermal therapy based on PEG-GO [29]. The safety and tumour accumulation of PEG-GO has been reported by Miao and co-workers [30]. Functionalized PEG-nGO