Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

• of PLG (DP = 20) in the development of a novel gene delivery system. In this study, surface-modified complexes were designed using PLG as a backbone to which polyethylene glycol (PEG, Mw = 5, 10, and 20 kDa) or epidermal growth factor (EGF) were conjugated [101]. This approach aimed to enhance the

• stability and transfection efficiency of DNA–PLL complexes. The study found that the incorporation of PLG significantly improved the performance of the gene delivery system, with the PLG-conjugated complexes achieving up to 25-fold higher transfection efficiency compared to unmodified complexes. Although

Cardiomyocyte uptake mechanism of a hydroxyapatite nanoparticle mediated gene delivery system

• Hiroaki Komuro,
• Masahiro Yamazoe,
• Kosuke Nozaki,
• Akiko Nagai and
• Tetsuo Sasano

Beilstein J. Nanotechnol. 2020, 11, 1685–1692, doi:10.3762/bjnano.11.150

• . Furthermore, this HL-1 cell uptake was generated in response to HAp stimulation. Thus, HAp is a positive regulator of macropinocytosis in HL-1 cells and a good system for gene delivery in cardiomyocytes. Keywords: cardiomyocyte; endocytosis; gene delivery system; hydroxyapatite nanoparticles

• acquisition at inflammation sites. Further studies regarding the role of CaSR and its downstream signaling pathways in HL-1 cells are required. Although the HAp-based vector used here has a low transfection efficiency, it has already been used as a gene delivery system in in vivo cancer research experiments

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

• Yasuhiko Onishi,
• Yuki Eshita,
• Rui-Cheng Ji,
• Masayasu Onishi,
• Takashi Kobayashi,
• Masaaki Mizuno,
• Jun Yoshida and
• Naoji Kubota

Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238

• an anticancer agent can be prevented if the agent promotes positive allosteric modulation according to the enzyme reaction model of a 1:1 ratio of a substrate and enzyme, which is the ratio utilized in vivo. Gene delivery system On the other hand, development of the gene delivery system in field of