Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• nanoparticles (AuNPs) with polyoxometalate and the peptides POMD and LPFFD (AuNPs@POMD-pep) have shown inhibition of Aβ1 aggregation and Aβ-induced cytotoxicity. However, the inherent toxicity of this formulation, challenges in particle digestion, and the potential for triggering immune reactions remain

• neuronal mitochondria, as evidenced by fluorescence intensities identified in brain homogenates, and reduced Aβ1 deposition, demonstrating the ability of the nanocomposite to cross the BBB [71]. Inorganic nanoparticles exhibit unique optical, magnetic, and chemical properties and stability. Gold

Enhanced catalytic reduction through in situ synthesized gold nanoparticles embedded in glucosamine/alginate nanocomposites

• Chi-Hien Dang,
• Le-Kim-Thuy Nguyen,
• Minh-Trong Tran,
• Van-Dung Le,
• Nguyen Minh Ty,
• T. Ngoc Han Pham,
• Hieu Vu-Quang,
• Tran Thi Kim Chi,
• Tran Thi Huong Giang,
• Nguyen Thi Thanh Tu and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2024, 15, 1227–1237, doi:10.3762/bjnano.15.99

• synthesizing gold nanoparticles (AuNPs) within a glucosamine/alginate (GluN/Alg) nanocomposite via an ionotropic gelation mechanism in aqueous environment. The resulting nanocomposite, AuNPs@GluN/Alg, underwent thorough characterization using UV–vis, EDX, FTIR, SEM, TEM, SAED, and XRD analyses. The spherical

• nanocomposite as a versatile catalyst with promising applications across various industrial sectors. Keywords: catalysis; gold nanoparticles; organic dyes; organometallic nanocomposites; reduction; Introduction Gold nanoparticles (AuNPs) have garnered significant attention because of their exceptional

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

• Nabojit Das,
• Vikas,
• Akash Kumar,
• Sanjeev Soni and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56

• anisotropic gold nanoparticles (AuNPs) have been synthesized and studied in recent years including nanorings, nanoprisms, nanoplates, crooked nanorods, dendrimers, nanocubes, nanodumbells, dogbones, and nanomakura [7][8][9][10][11][12][13][14]. Vis-à-vis to spherical nanoparticles, anisotropic nanoparticles

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• the conjugation of gold nanoparticles (AuNPs) with an anti-epithelial sodium channel (ENaC), known as a marker for arterial hypertension found in membrane platelets [186]. Beyond nanotechnology, the field has witnessed developments in metallic biomaterials for vascular tissue engineering. Titanium

N-Heterocyclic carbene-based gold etchants

• Robert B. Chevalier,
• Justin Pantano,
• Matthew K. Kiesewetter and
• Jason R. Dwyer

Beilstein J. Nanotechnol. 2023, 14, 865–871, doi:10.3762/bjnano.14.71

• reported the use of a benzimidazolium gold complex in dichloromethane (DCM) that readily functionalizes gold nanoparticles (AuNPs) in aqueous solution [15][19]. In our work using solution-based approaches to form NHC monolayers on gold thin films, we observed a loss of gold from our substrates. It is

Rapid and sensitive detection of box turtles using an electrochemical DNA biosensor based on a gold/graphene nanocomposite

• Abu Hashem,
• M. A. Motalib Hossain,
• Ab Rahman Marlinda,
• Mohammad Al Mamun,
• Khanom Simarani and
• Mohd Rafie Johan

Beilstein J. Nanotechnol. 2022, 13, 1458–1472, doi:10.3762/bjnano.13.120

• nanoparticles (AuNPs) [32] based nanocomposites are well established [41] due to their excellent performance. In particular, self-decorated AuNPs in the honeycomb-structured graphene lattice could facilitate the accommodation of a greater number of recognition probes. In addition, Gr is a nanomaterial with a

• the applications of impedance DNA hybridisation biosensors for the detection of a number of analytes [31][32][33][34]. Nanomaterials may significantly enhance biosensor performance, stability, repeatability, and sensitivity [35][36][37][38][39]. Among various nanomaterials, graphene (Gr) [40] and gold

Facile preparation of Au- and BODIPY-grafted lipid nanoparticles for synergized photothermal therapy

• Yuran Wang,
• Xudong Li,
• Haijun Chen and
• Yu Gao

Beilstein J. Nanotechnol. 2022, 13, 1432–1444, doi:10.3762/bjnano.13.118

• specificity and minimal invasiveness, it has attracted a great deal of attention as complementary modality for conventional cancer therapy options [1]. Gold nanoparticles (AuNPs) can absorb light and generate heat from light absorption because of the surface plasmon resonance (SPR) phenomenon and the tunable

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

• Se-Kwon Kim,
• Sesha Subramanian Murugan,
• Pandurang Appana Dalavi,
• Sebanti Gupta,
• Sukumaran Anil,
• Gi Hun Seong and
• Jayachandran Venkatesan

Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92

• . Further, the developed material shows apatite formation in SBF and it stimulates the growth of MG-63 osteoblast-like cells. In addition, antibacterial activity was discovered against Staphylococcus aureus [85]. Chitosan–gold nanocomposites Gold nanoparticles (AuNPs) have been extensively studied for

Impact of device design on the electronic and optoelectronic properties of integrated Ru-terpyridine complexes

• Max Mennicken,
• Sophia Katharina Peter,
• Corinna Kaulen,
• Ulrich Simon and
• Silvia Karthäuser

Beilstein J. Nanotechnol. 2022, 13, 219–229, doi:10.3762/bjnano.13.16

• the wire-growth protocol developed recently and, thus, to assemble Ru(TP)2-complex wire nanodevices [19]. Additionally, we will use our already successfully applied approach to fabricate nanodevices from ligand-stabilized gold nanoparticles (AuNPs) immobilized between nanoelectrodes [21][22][23][24

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• nanoparticles (AuNPs); blood–brain barrier (BBB); drug delivery; liposomes; nanomedicine; polymeric nanoparticles; solid lipid nanoparticles; superparamagnetic iron oxide nanoparticles (SPIONs); Introduction Neurological disorders and brain diseases are real burdens for modern societies and healthcare systems

• factors needs to be taken into account when developing a carrier system for this purpose. Depending on the chosen pathway to cross the BBB, nanoparticle material, size and surface properties such as functionalization and charge should be tailored to fit the specific route of BBB crossing. Keywords: gold

Luminescent gold nanoclusters for bioimaging applications

• Nonappa

Beilstein J. Nanotechnol. 2020, 11, 533–546, doi:10.3762/bjnano.11.42

• photostability, and the PL can be tuned from the visible to the NIR region [29]. Similar to SCQDs, SQDs undergo oxidation at room temperature and have limited water solubility. Recently, gold nanoparticles (AuNPs) with tunable size and shape-specific physicochemical properties have emerged as attractive

Long-term stability and scale-up of noncovalently bound gold nanoparticle-siRNA suspensions

• Anna V. Epanchintseva,
• Julia E. Poletaeva,
• Dmitrii V. Pyshnyi,
• Elena I. Ryabchikova and
• Inna A. Pyshnaya

Beilstein J. Nanotechnol. 2019, 10, 2568–2578, doi:10.3762/bjnano.10.248

• nanoparticles (AuNPs) are a platform for the creation of nanoconstructions that can have a variety of functions, including the delivery of therapeutic nucleic acids. We previously designed a AuNP/small interfering RNA (siRNA) nanoconstruction consisting of siRNA noncovalently bound on the AuNP surface and

• Anna V. Epanchintseva Julia E. Poletaeva Dmitrii V. Pyshnyi Elena I. Ryabchikova Inna A. Pyshnaya Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, Lavrent’ev av., 8, Novosibirsk, 630090, Russian Federation 10.3762/bjnano.10.248 Abstract Gold

Small protein sequences can induce cellular uptake of complex nanohybrids

• Jan-Philip Merkl,
• Malak Safi,
• Christian Schmidtke,
• Fadi Aldeek,
• Johannes Ostermann,
• Tatiana Domitrovic,
• Sebastian Gärtner,
• John E. Johnson,
• Horst Weller and
• Hedi Mattoussi

Beilstein J. Nanotechnol. 2019, 10, 2477–2482, doi:10.3762/bjnano.10.238

• hybrid system consisting of self-assembled gold nanoparticles (AuNPs) and polymer-encapsulated QDs. These constructs were further functionalized with polyhistidine-tagged proteins, yielding functional conjugates that exhibit fluorescent and plasmonic properties [8]. Over the last two decades several

Use of data processing for rapid detection of the prostate-specific antigen biomarker using immunomagnetic sandwich-type sensors

• Camila A. Proença,
• Tayane A. Freitas,
• Thaísa A. Baldo,
• Elsa M. Materón,
• Flávio M. Shimizu,
• Gabriella R. Ferreira,
• Frederico L. F. Soares,
• Ronaldo C. Faria and
• Osvaldo N. Oliveira Jr.

Beilstein J. Nanotechnol. 2019, 10, 2171–2181, doi:10.3762/bjnano.10.210

• polyclonal antibody, (3) capture of biomarker by the bioconjugate, (4) sandwich formation by injection of the biomarker captured by Ab2-MNP-HRP in the microfluidic system. The first step included the deposition of a bilayer of poly(diallyldimethylammonium) (PDDA) and gold nanoparticles (AuNPs) decorated with

Gold-coated plant virus as computed tomography imaging contrast agent

• Alaa A. A. Aljabali,
• Mazhar S. Al Zoubi,
• Khalid M. Al-Batanyeh,
• Ali Al-Radaideh,
• Mohammad A. Obeid,
• Abeer Al Sharabi,
• Walhan Alshaer,
• Bayan AbuFares,
• Tasnim Al-Zanati,
• Murtaza M. Tambuwala,
• Naveed Akbar and
• David J. Evans

Beilstein J. Nanotechnol. 2019, 10, 1983–1993, doi:10.3762/bjnano.10.195

• contrast agents including gold nanoparticles (AuNPs) [13], bromine [14], platinum [15], ytterbium [16], gadolinium [4], and tungsten [15]. Many of the systems are made up of a core that is coated with a polymeric material such as liposomes [17], micelles [13], lipoproteins or polymeric nanoparticles [18

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione

• Barbara Pem,
• Igor M. Pongrac,
• Lea Ulm,
• Ivan Pavičić,
• Valerije Vrček,
• Darija Domazet Jurašin,
• Marija Ljubojević,
• Adela Krivohlavek and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2019, 10, 1802–1817, doi:10.3762/bjnano.10.175

• Zagreb, Croatia 10.3762/bjnano.10.175 Abstract This study was designed to evaluate the nano–bio interactions between endogenous biothiols (cysteine and glutathione) with biomedically relevant, metallic nanoparticles (silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs)), in order to assess the

• with time. Transmission electron micrographs of silver (AgNPs) and gold nanoparticles (AuNPs) prepared in the presence of cysteine (CYS) or glutathione (GSH). (a) Viability of L929 cells exposed to silver (AgNPs) and gold nanoparticles (AuNPs) stabilized with cysteine (CYS) or glutathione (GSH), Ag

• reflective spots (g), while NP reflectance signals are visible as bright red signals and indicated by white arrows (c,d). The effect of silver (AgNPs) and gold nanoparticles (AuNPs) stabilized with cysteine (CYS) or glutathione (GSH), Ag+ and Au3+ ions on (a) total DNA damage and (b) DNA double-stranded

Growth dynamics and light scattering of gold nanoparticles in situ synthesized at high concentration in thin polymer films

• Corentin Guyot,
• Philippe Vandestrick,
• Ingrid Marenne,
• Olivier Deparis and
• Michel Voué

Beilstein J. Nanotechnol. 2019, 10, 1768–1777, doi:10.3762/bjnano.10.172

• properties of plasmonic nanocomposite materials from experimental, theoretical as well as numerical points of view [1][2]. Metal nanoparticles (NPs) play a central role in the development of nanotechnology-based optical devices. Gold nanoparticles (AuNPs) are used in spectrally selective coatings to block

Highly ordered mesoporous silica film nanocomposites containing gold nanoparticles for the catalytic reduction of 4-nitrophenol

• Mohamad Azani Jalani,
• Leny Yuliati,
• Siew Ling Lee and
• Hendrik O. Lintang

Beilstein J. Nanotechnol. 2019, 10, 1368–1379, doi:10.3762/bjnano.10.135

• the performance for the above-mentioned applications, it is crucial to find a method for template removal. As a host for metal nanoparticles, mesoporous matrixes have been extensively used for the controlled growth of gold nanoparticles (AuNPs) [11][19]. For mesoporous silica, gold sources derived

Correlation of surface-enhanced Raman scattering (SERS) with the surface density of gold nanoparticles: evaluation of the critical number of SERS tags for a detectable signal

• Vincenzo Amendola

Beilstein J. Nanotechnol. 2019, 10, 1016–1023, doi:10.3762/bjnano.10.102

• suitability of plasmonic SERS labels for ultrasensitive analytical and biomedical applications is evident. Keywords: discrete dipole approximation (DDA); gold nanoparticles (AuNPs); nanotags; surface-enhanced Raman scattering (SERS); surface plasmon resonance (SPR); Introduction In surface-enhanced Raman

Gold nanoparticles embedded in a polymer as a 3D-printable dichroic nanocomposite material

• Lars Kool,
• Anton Bunschoten,
• Aldrik H. Velders and
• Vittorio Saggiomo

Beilstein J. Nanotechnol. 2019, 10, 442–447, doi:10.3762/bjnano.10.43

• due to gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) of different sizes and shapes [9][10]. However, only the Lycurgus cup, now stored in the British Museum, and six other broken pieces showing the same dichroic effect were found worldwide, hinting that the achievement of such an optical

Comparison of four functionalization methods of gold nanoparticles for enhancing the enzyme-linked immunosorbent assay (ELISA)

• Paula Ciaurriz,
• Fátima Fernández,
• Edurne Tellechea,
• Jose F. Moran and
• Aaron C. Asensio

Beilstein J. Nanotechnol. 2017, 8, 244–253, doi:10.3762/bjnano.8.27

• functionalization for ELISA enhancement. In this work, we use 20 nm gold nanoparticles (AuNPs) as a vehicle for secondary antibodies and peroxidase (HRP). The design of experiments technique (DOE) and four different methods for biomolecule loading were compared using a rabbit IgG/goat anti-rabbit IgG ELISA model

• protein by functionalized multiwalled carbon nanotubes was observed by Zhang et al. [7]. However, the most significant improvements in signal have been rendered by gold nanoparticles (AuNPs), presenting promising unique chemical and physical properties, as well as biological compatibility [5][14][15

Influence of hydrofluoric acid treatment on electroless deposition of Au clusters

• Rachela G. Milazzo,
• Antonio M. Mio,
• Giuseppe D’Arrigo,
• Emanuele Smecca,
• Alessandra Alberti,
• Gabriele Fisichella,
• Filippo Giannazzo,
• Corrado Spinella and
• Emanuele Rimini

Beilstein J. Nanotechnol. 2017, 8, 183–189, doi:10.3762/bjnano.8.19

• Astronomy, v. S. Sofia 64, I-95123, Catania, Italy 10.3762/bjnano.8.19 Abstract The morphology of gold nanoparticles (AuNPs) deposited on a (100) silicon wafer by simple immersion in a solution containing a metal salt and hydrofluoric acid (HF) is altered by HF treatment both before and after deposition

Streptavidin-coated gold nanoparticles: critical role of oligonucleotides on stability and fractal aggregation

• Roberta D'Agata,
• Pasquale Palladino and
• Giuseppe Spoto

Beilstein J. Nanotechnol. 2017, 8, 1–11, doi:10.3762/bjnano.8.1

• Andrea Doria 6, I-95125, Catania, Italy 10.3762/bjnano.8.1 Abstract Gold nanoparticles (AuNPs) exhibit unique properties that can be modulated through a tailored surface functionalization, enabling their targeted use in biochemical sensing and medical diagnostics. In particular, streptavidin-modified

• colloids have been the focus of research for many decades because of their intriguing electronic and optical properties, depending on the size and shape of gold nanoparticles (AuNPs) [1], which support several biomedical and pharmaceutical applications [2]. The functionalization of AuNPs with biologically

Effect of Anderson localization on light emission from gold nanoparticle aggregates

• Mohamed H. Abdellatif,
• Marco Salerno,
• Gaser N. Abdelrasoul,
• Ioannis Liakos,
• Alice Scarpellini,
• Sergio Marras and
• Alberto Diaspro

Beilstein J. Nanotechnol. 2016, 7, 2013–2022, doi:10.3762/bjnano.7.192

• size and shape of the nanostructured system. In this work, we studied the photoluminescence dependence of aggregates of 14 nm diameter gold nanoparticles (AuNPs) synthesized by drop-casting a liquid suspension on two different substrates of glass and quartz. The AuNP aggregates were characterized by

• strong optical nonlinearity, which brings in many opportunities for useful applications. For example, the third order nonlinear susceptibility χ(3) of gold nanoparticles (AuNPs) (χ(3) < 1 nm2V−2) [13] is three orders of magnitude higher than that of nonlinear crystals such as potassium di-hydrogen

Layered composites of PEDOT/PSS/nanoparticles and PEDOT/PSS/phthalocyanines as electron mediators for sensors and biosensors

• Celia García-Hernández,
• Cristina García-Cabezón,
• Fernando Martín-Pedrosa,
• José Antonio De Saja and
• María Luz Rodríguez-Méndez

Beilstein J. Nanotechnol. 2016, 7, 1948–1959, doi:10.3762/bjnano.7.186

• EMs, three different materials with different characteristics and electrocatalytic activity towards phenols were tested, including gold nanoparticles (AuNPs), a copper phthalocyanine (CuPc) (a p-type semiconductor) and a lutetium bisphthalocyanine (LuPc2) (a sandwich-type derivative with free radical