Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Muhammad Waqas,
• Ahsan Nazir and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 591–612, doi:10.3762/bjnano.16.46

• kinetics. The degradation is also affected by surface-modifying macromolecules (SMMs). A variety of SMMs resists enzymatic action. Some SMM formulations are incompatible with PU, which can increase biodegradability. For the medical field, biodegradable polyester PU is derived from polycaprolactone diols

Water in nanoporous hexagonal boron nitride nanosheets: a first-principles study

• Juliana A. Gonçalves,
• Ronaldo J. C. Batista and
• Marcia C. Barbosa

Beilstein J. Nanotechnol. 2025, 16, 510–519, doi:10.3762/bjnano.16.39

• . Experimental evidence supports the occurrence of these kinds of vertex configurations [34]. Liu and colleagues [35] demonstrated that two-dimensional hexagonal boron nitride macromolecules exhibit enhanced stability when passivated with hydroxy (–OH) and secondary amino (–NH) groups. Inspired by this finding

• /atom smaller than that caused by the addition of B–OH moieties. This result differs from the findings of Liu and colleagues on h-BN macromolecules [35]. We attribute this difference to the heightened repulsion among atoms within the triangular pore, as B–OH moieties occupy more space than B–H pairs. In

• the case of h-BN macromolecules, as studied by Liu and colleagues, similar confinement effects do not exist, allowing B–OH terminations to enhance stability relative to B–H terminations. This is similar to the situation with larger pores, such as rhombic pores, where confinement effects are minimal or

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

• [111]. Thanks to the ability of PEI to efficiently bind negatively charged macromolecules and overcome cellular barriers, PEI-based systems have been extensively investigated for targeted antisense oligonucleotide and gene delivery. In 2011, Yang et al. studied the bioactivity in vitro and in vivo of

• coworkers [128], study and synthesis of poly(propylene imine) (PPI) dendrimers for drug and gene delivery have grown exponentially [129][130]. PPI dendrimers are highly branched, tree-like macromolecules with well-defined structures and dense positively surface charge comprised of a backbone of tertiary

Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

• Radmila Milenkovska,
• Nikola Geskovski,
• Dushko Shalabalija,
• Ljubica Mihailova,
• Petre Makreski,
• Dushko Lukarski,
• Igor Stojkovski,
• Maja Simonoska Crcarevska and
• Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

• -methylguanine lesions and/or mutations that ultimatively avoid mismatch repair system and lead to apoptosis, autophagia, and cell senescence. Aside from the methylation in the O6 position of guanine, TMZ has shown an ability to alkylate other macromolecules with an important role in many cell processes related

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• this context, biomimetic strategies using natural components emerge as revolutionary tools to overcome these challenges. The utilization of cellular components or parts thereof, such as macromolecules or membranes, can enhance drug delivery and therapeutic efficiency in the human body, representing a

Enhanced catalytic reduction through in situ synthesized gold nanoparticles embedded in glucosamine/alginate nanocomposites

• Chi-Hien Dang,
• Le-Kim-Thuy Nguyen,
• Minh-Trong Tran,
• Van-Dung Le,
• Nguyen Minh Ty,
• T. Ngoc Han Pham,
• Hieu Vu-Quang,
• Tran Thi Kim Chi,
• Tran Thi Huong Giang,
• Nguyen Thi Thanh Tu and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2024, 15, 1227–1237, doi:10.3762/bjnano.15.99

• electrostatic bonds with multivalent metal cations (such as Ca2+, Ba2+, and Cu2+) to create an extensive gel network in water [15][16]. The cross-linking of saccharide chains within alginate generates macromolecules ranging in size from micrometers to millimeters, resulting in gelispheres insoluble in water

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors

• Joyita Roy and
• Kunal Roy

Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27

• different areas [1]. However, the innovation of nanomaterials (NMs) is hindered because of potential adverse effects. It is believed that small particles can enter the body through inhalation, ingestion, and skin penetration and have the potency to interact with macromolecules for a long period. Many

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• delivered via these nanostructured systems. Polymeric nanoparticles Polymeric nanoparticles (PNPs) are colloidal systems made of natural or synthetic polymers [98]. These systems can encapsulate or adsorb active pharmaceutical ingredients (APIs) and macromolecules [99][100][101]. In addition, PNPs can

Upscaling the urea method synthesis of CoAl layered double hydroxides

• Camilo Jaramillo-Hernández,
• Víctor Oestreicher,
• Martín Mizrahi and
• Gonzalo Abellán

Beilstein J. Nanotechnol. 2023, 14, 927–938, doi:10.3762/bjnano.14.76

• < x < 0.33). An− symbolizes a constituent ranging from (in)organic anions to macromolecules, and Sv stands for solvent molecules. This general composition leads to a plethora of highly tunable systems [12][13][14][15][16] with relevance in environmental applications [17], photocatalysis [18], energy

Industrial perspectives for personalized microneedles

• Remmi Danae Baker-Sediako,
• Benjamin Richter,
• Matthias Blaicher,
• Michael Thiel and
• Martin Hermatschweiler

Beilstein J. Nanotechnol. 2023, 14, 857–864, doi:10.3762/bjnano.14.70

• are several subspecies of mosquitos, such as Aedes aegypti, that have evolved to specialize in human hosts [35]. An adapted design would be advantageous for painless transdermal delivery of macromolecules or biological sampling [38]. Adult ticks, as another example, live on their hosts for 7–10 days

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• macromolecules under aerobic and anaerobic conditions [5]. Cure rates are high when BNZ is administered during the acute phase [6]; however, in the chronic stage the cure rate is estimated to be less than 10% [7]. Some authors differ about this percentage owing to the variability in sensibility of the tests that

Polymer nanoparticles from low-energy nanoemulsions for biomedical applications

• Santiago Grijalvo and
• Carlos Rodriguez-Abreu

Beilstein J. Nanotechnol. 2023, 14, 339–350, doi:10.3762/bjnano.14.29

• cellulose, PLGA, and polyurethane/polyurea nanoparticles in the form of colloidal suspensions to enable the encapsulation of not only small molecule drugs but also macromolecules. This strategy improved pharmacokinetic properties and biological activities both in vitro and in vivo, showing great promise for

Solvent-induced assembly of mono- and divalent silica nanoparticles

• Bin Liu,
• Etienne Duguet and
• Serge Ravaine

Beilstein J. Nanotechnol. 2023, 14, 52–60, doi:10.3762/bjnano.14.6

• shell of approx. 15 nm (as estimated by transmission electron microscopy, TEM). The latter is made up of covalently grafted PS macromolecules resulting from the copolymerization of styrene with methacryloxymethyl groups. As previously demonstrated [25], these PS chains can serve as sticky patches when

• between nanoparticles due to negatively charged silanolate groups at their surface and also the solvent quality for the PS macromolecules. Minimization of the free surface energy of the system thus corresponds to the formation of physical bonds between the nanoparticles [34][35], which behave as sticky

Induced electric conductivity in organic polymers

• Konstantin Y. Arutyunov,
• Anatoli S. Gurski,
• Vladimir V. Artemov,
• Alexander L. Vasiliev,
• Azat R. Yusupov,
• Danfis D. Karamov and
• Alexei N. Lachinov

Beilstein J. Nanotechnol. 2022, 13, 1551–1557, doi:10.3762/bjnano.13.128

• temperature of 150–200 °C for 45 min. Depending on the concentration of the solutions, it was possible to obtain films of various thicknesses from several nm to several μm. The formation of films from dilute solutions occurs according to the mechanism of linear or loop adsorption, when macromolecules at the

• interface are completely or partially elongated. Also, film formation at such low concentrations strongly depends on the energy interaction of macromolecules with the substrate surface, which explains the weak dependence of the film thickness on the solution concentration. With an increase in concentration

• , associates of macromolecules are formed in the solution, and the influence of adhesion processes decreases, but the cohesive forces increase. In the entire thickness range from 3 nm to 1 µm, the films are solid, without significant defects and/or pin holes. The polymer films were studied by atomic force

Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics

• Sedat Ünal,
• Osman Doğan and
• Yeşim Aktaş

Beilstein J. Nanotechnol. 2022, 13, 1393–1407, doi:10.3762/bjnano.13.115

• adsorption of CS macromolecules on the surface of the NPs [42]. Besides coating, drug loading to NPs also led to remarkable changes in particle size. Moreover, after CS coating, the zeta potential of PLGA NPs changed from negative to positive. The negative zeta potential is attributed to the presence of

Studies of probe tip materials by atomic force microscopy: a review

• Ke Xu and
• Yuzhe Liu

Beilstein J. Nanotechnol. 2022, 13, 1256–1267, doi:10.3762/bjnano.13.104

• changes in the biological activity of proteins, so they are widely used as an immunolabeling probe in immunocytochemistry, and with the rapid development of molecular biology, colloidal gold labeling techniques are used as a means to perform precise localization of biological macromolecules such as cell

Design of surface nanostructures for chirality sensing based on quartz crystal microbalance

• Yinglin Ma,
• Xiangyun Xiao and
• Qingmin Ji

Beilstein J. Nanotechnol. 2022, 13, 1201–1219, doi:10.3762/bjnano.13.100

• ; chiral surface; chirality recognition; quartz crystal microbalance (QCM); sensing applications; surface architecture; Introduction Chirality is a prevalent phenomenon in nature. Many common biological macromolecules such as proteins, ribose, and cellulose are inherently chiral. Chiral molecules have two

• affinity between proteins and chiral selectors. It was elucidated that stereoselective hydrophobic interactions are the major driving forces that govern protein adsorption on ʟ-Val-modified surfaces. Besides small biomolecules, biological macromolecules, such as proteins and enzymes, also show natural

Bioselectivity of silk protein-based materials and their bio-inspired applications

• Hendrik Bargel,
• Vanessa T. Trossmann,
• Christoph Sommer and
• Thomas Scheibel

Beilstein J. Nanotechnol. 2022, 13, 902–921, doi:10.3762/bjnano.13.81

• organic and inorganic macromolecules that absorb on the underlying materials. The various locomotive appendices, the glycocalyx, and hydrophobic molecules mediating non-specific binding interactions help bacterial attachment even in presence of repulsive forces [77][78]. To address the target protein

Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading

• Agnes-Valencia Weiss,
• Daniel Schorr,
• Julia K. Metz,
• Metin Yildirim,
• Saeed Ahmad Khan and
• Marc Schneider

Beilstein J. Nanotechnol. 2022, 13, 778–787, doi:10.3762/bjnano.13.68

• macromolecules, such as proteins [12] and peptides [13], or in the field of gene delivery [14]. The surface charge of gelatin nanoparticles at physiological pH can be easily influenced by the choice of gelatin type [15]. Crosslinking of gelatin nanoparticles is still inevitable to obtain particles that are

Effects of substrate stiffness on the viscoelasticity and migration of prostate cancer cells examined by atomic force microscopy

• Xiaoqiong Tang,
• Yan Zhang,
• Jiangbing Mao,
• Yuhua Wang,
• Zhenghong Zhang,
• Zhengchao Wang and
• Hongqin Yang

Beilstein J. Nanotechnol. 2022, 13, 560–569, doi:10.3762/bjnano.13.47

• importance to the clinical management of PCa. There are many factors that mediate tumour metastasis. Of these, the extracellular matrix (ECM) is most closely associated with tumour metastasis. The ECM is made of extracellularly secreted macromolecules. It not only contains a large number of biochemical

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

• involvement of micro-/nanotechnological possibilities in the process of scaffold design and fabrication [4]. Since a lot of cellular mechanisms are controlled by environmental stimuli (cell signaling molecules, extracellular matrix, and bioactive macromolecules) on the nanoscale, the recognition and

Systematic studies into uniform synthetic protein nanoparticles

• Nahal Habibi,
• Ava Mauser,
• Jeffery E. Raymond and
• Joerg Lahann

Beilstein J. Nanotechnol. 2022, 13, 274–283, doi:10.3762/bjnano.13.22

• , the bias between the jetting needle and collection substrate. A stable jet is achieved with the assistance of a constant pumping rate, to generate a Taylor cone that resolves into individual microdroplets that contain a very limited amount of macromolecules. During travel from the onset of the cone

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• physiological cell activity, while greater levels result in signaling loss and unspecific damage to cellular macromolecules, contributing to various pathologies [28]. The generation of excessive ROS by TiO2 can lead to fibrosis, allergy, even organ failure, and other toxicities in the human body. It was also

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• and macromolecules including influenza vaccines and insulin [19][20][21]. Research showed effective delivery of solid-state influenza vaccine into mice skin by microneedles [22], and delivery of macromolecular drugs to deep skin tissues of rats by a minimally invasive system consisting of microneedles