Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

• Hsuan-Ang Tsai,
• Tsai-Miao Shih,
• Theodore Tsai,
• Jhe-Wei Hu,
• Yi-An Lai,
• Jui-Fu Hsiao and
• Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

• , matrix, and microneedle systems [24][25][26]. In addition, enteric-coated solid dosage forms for oral administration have shown significant improvement in providing better absorption and targeted delivery [27][28]. In this study, due to high water solubility of DCS (Log P = −1.72) and difficulty to

Industrial perspectives for personalized microneedles

• Remmi Danae Baker-Sediako,
• Benjamin Richter,
• Matthias Blaicher,
• Michael Thiel and
• Martin Hermatschweiler

Beilstein J. Nanotechnol. 2023, 14, 857–864, doi:10.3762/bjnano.14.70

• Remmi Danae Baker-Sediako Benjamin Richter Matthias Blaicher Michael Thiel Martin Hermatschweiler Nanoscribe Gmbh & Co, Hermann-von-Helmholtz-Platz 6, 76344 Eggenstein-Leopoldshafen, Germany 10.3762/bjnano.14.70 Abstract Microneedles and, subsequently, microneedle arrays are emerging miniaturized

• medical devices for painless transdermal drug delivery. New and improved additive manufacturing methods enable novel microneedle designs to be realized for preclinical and clinical trial assessments. However, current literature reviews suggest that industrial manufacturers and researchers have focused

• their efforts on one-size-fits-all designs for transdermal drug delivery, regardless of patient demographic and injection site. In this perspective article, we briefly review current microneedle designs, microfabrication methods, and industrialization strategies. We also provide an outlook where

Microneedle patches – the future of drug delivery and vaccination?

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2023, 14, 494–495, doi:10.3762/bjnano.14.40

• , and MN patch diagnostic systems barely appear on the research landscape. Microneedle vaccination patches are closer to clinical acceptance and have enormous promise, given the demand for high volume, low cost, rapidly deployable vaccination in response to pandemics like COVID-19 [4], and companies

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• immunotherapy can trigger antitumor-specific immune responses and establish long-term immune memory [118]. Cancer cell membranes have become a unique method for the preparation of biomimetic nanovaccines due to the numerous tumor-specific antigens carried on their surfaces [118]. A type of microneedle

Microneedle-based ocular drug delivery systems – recent advances and challenges

• Piotr Gadziński,
• Anna Froelich,
• Monika Wojtyłko,
• Antoni Białek,
• Julia Krysztofiak and
• Tomasz Osmałek

Beilstein J. Nanotechnol. 2022, 13, 1167–1184, doi:10.3762/bjnano.13.98

• developments in microtechnology, in recent years, there has been a remarkable advance in the development of microneedle-based systems as an alternative, non-invasive form for administering drugs to the eye. This review summarizes the latest achievements in the field of obtaining microneedle ocular patches. In

• the manuscript, the most important manufacturing technologies, microneedle classification, and the research studies related to ophthalmic application of microneedles are presented. Finally, the most important advantages and drawbacks, as well as potential challenges related to the unique anatomy and

• and revolutionize the treatment of ophthalmic diseases [99]. However, due to the very small size, injections with the use of microneedles require properly trained specialists as well as the use of advanced equipment [95][100]. Simultaneously with the development of single-microneedle technologies

Fabrication and testing of polymer microneedles for transdermal drug delivery

• Vahid Ebrahiminejad,
• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2022, 13, 629–640, doi:10.3762/bjnano.13.55

• -Thames, OX10 7HN, United Kingdom Faculty of Engineering, University of New South Wales, Sydney, NSW 2052, Australia College of Engineering & Physical Sciences, School of Engineering, University of Birmingham, Birmingham, B15 2TT, United Kingdom 10.3762/bjnano.13.55 Abstract Microneedle (MN) patches have

Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections

• Sharif Abdelghany,
• Walhan Alshaer,
• Yazan Al Thaher,
• Maram Al Fawares,
• Amal G. Al-Bakri,
• Saja Zuriekat and
• Randa SH. Mansour

Beilstein J. Nanotechnol. 2022, 13, 517–527, doi:10.3762/bjnano.13.43

• incorporated into a polymer matrix of PVA and PVP with a weight ratio of (9:1), and CIP_MN2, composed of 10 mg ciprofloxacin incorporated into PVA polymer. CIP_MN1 and CIP_MN2 showed a mean microneedle height of 188 and 179 µm, respectively. Since Parafilm has been proven as a model to examine the perforation

• model. This was evidenced by a zone of inhibition of 29 mm for the microneedle formulation of ciprofloxacin (CIP_MN1) compared to 2 mm for the free gel of ciprofloxacin. Furthermore, the CIP_MN1 showed complete dissolution in human skin after 60 min from application. Finally, the skin deposition of

• microneedles in reducing the microbial burden in bacterial and fungal skin infections [6][7]. Herein, we are aiming at providing a potential microneedle delivery system for the treatment of staphylococcal skin and soft tissue infections such as cellulitis. Cellulitis, as an example of common bacterial skin

Design and characterization of polymeric microneedles containing extracts of Brazilian green propolis

• Camila Felix Vecchi,
• Rafaela Said dos Santos,
• Jéssica Bassi da Silva and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2022, 13, 503–516, doi:10.3762/bjnano.13.42

• : development; mechanical; microneedles; propolis extract; technology; Introduction In recent decades, microneedle devices have been widely used for non-invasive dermal delivery of various drugs [1][2][3]. Microneedles (MNs) are large enough to penetrate and open small holes only in the stratum corneum and the

• determinations were performed for each assay [36][46][47][48]. Preparation of silicone molds The master structure utilized to fabricate the molds was a stainless-steel microneedle system (cartridge) from DermaPen (Belrose, Australia) containing 36 microneedles of 2 mm in length. The molds developed were inverse

• another 5 min. The microneedle cartridge was inserted into the mixture and placed under ultrasound for 5 min to remove all air bubbles. The plate containing the silicone and the microneedle cartridge was placed in a vacuum desiccator for silicone curing. After 24 h, the cartridge was carefully removed and

Tubular glassy carbon microneedles with fullerene-like tips for biomedical applications

• Sharali Malik and
• George E. Kostakis

Beilstein J. Nanotechnol. 2022, 13, 455–461, doi:10.3762/bjnano.13.38

• glassy carbons relevant to the application of glassy carbons as a biomaterial, for example, as a new form of carbon-based microneedles. Since metallic needles can introduce toxic/allergenic species into susceptible subjects, this alternative carbon-based microneedle form has great potential as a

• replacement biomedical material for metallic needles in the field of neural engineering and as acupuncture needles. Keywords: biomedical; glassy carbon; microneedle; neural engineering; COST Action EsSENce CA19118; Introduction Glassy carbon, also known as “glass-like carbon” or “vitreous carbon” is an

• procedure utilising catalytic methane pyrolysis to fabricate glassy carbon microneedle electrodes for biomedical applications. Results and Discussion Growth of glassy carbon microneedles Previously, glassy carbon microneedles have been made by the pyrolysis of commercially available polymers. The polymer

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• -on-Thames, OX10 7HN, United Kingdom Faculty of Engineering, UNSW Australia, NSW 2052, Australia College of Engineering & Physical Sciences, School of Engineering, University of Birmingham, Birmingham, B15 2TT, United Kingdom 10.3762/bjnano.12.77 Abstract Microneedle-based microdevices promise to

• expand the scope for delivery of vaccines and therapeutic agents through the skin and withdrawing biofluids for point-of-care diagnostics – so-called theranostics. Unskilled and painless applications of microneedle patches for blood collection or drug delivery are two of the advantages of microneedle

• arrays over hypodermic needles. Developing the necessary microneedle fabrication processes has the potential to dramatically impact the health care delivery system by changing the landscape of fluid sampling and subcutaneous drug delivery. Microneedle designs which range from sub-micron to millimetre