Beilstein J. Nanotechnol.2025,16, 435–463, doi:10.3762/bjnano.16.34
oligomer (PMO); phosphorothioate (PS); polyplexes; ribose substitutions; small interfering RNA (siRNA); synthetic polymers; tricyclo-DNA (tcDNA); Introduction
The development and use of personalised therapies tailored to individual patients have emerged as a powerful strategy for treating various
PDF
Figure 1:
Common chemical modifications used in antisense oligonucleotides (ASOs). First-generation ASOs invo...