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Search for "poloxamer" in Full Text gives 17 result(s) in Beilstein Journal of Nanotechnology.

Aprepitant-loaded solid lipid nanoparticles: a novel approach to enhance oral bioavailability

  • Mazhar Hussain,
  • Muhammad Farooq,
  • Muhammad Asad Saeed,
  • Muhammad Ijaz,
  • Sherjeel Adnan,
  • Zeeshan Masood,
  • Muhammad Waqas,
  • Wafa Ishaq and
  • Nabeela Ameer

Beilstein J. Nanotechnol. 2025, 16, 652–663, doi:10.3762/bjnano.16.50

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  • , Robert Stevenson Road, Edinburgh, EH9 3FB, United Kingdom 10.3762/bjnano.16.50 Abstract Objectives of the present study are the development of aprepitant (APT)-loaded solid lipid nanoparticles (SLNs) using the polymers poloxamer 407 and β-cyclodextrin for enhanced solubility and their pharmacokinetic
  • . Therefore, the optimal SLN formulation APT-CD-NP4 is a promising tool for oral administration with sustained release to improve the bioavailability of the BCS class-IV drug APT. Keywords: aprepitant; β-cyclodextrin; pharmacokinetic study; poloxamer; solid lipid nanoparticles; Introduction Cancer is a
  • than that of APT in PBS (pH 7.4) and acidic medium (0.1 M HCl, pH 1.2). The samples APT-CD-NP1 to APT-CD-NP4 contained β-cyclodextrin (β-CD), while samples APT-PX-NP5 to APT-PX-NP8 contained poloxamer 407, both in different proportions (Figure 1). The order of solubility was APT-CD-NP1 > APT-CD-NP2
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Published 15 May 2025

Development of a mucoadhesive drug delivery system and its interaction with gastric cells

  • Ahmet Baki Sahin,
  • Serdar Karakurt and
  • Deniz Sezlev Bilecen

Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28

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  • , A2033), poloxamer 407 (16758), calcium chloride, and mucin from porcine stomach (M1778) were purchased from Sigma-Aldrich, USA. Sunflower oil and sorbitan monooleate (Span 80) were from TCI Chemicals, USA. For in vitro studies, high-glucose DMEM and Pen-Step solution were purchased from Sartorius
  • , 40% Amp) for 10 min. At the end of sonication, CaCl2 (0.22 M, 1 mL) containing poloxamer 407 (1%, w/v) was dripped with an injector (Genject, Türkiye) into the mixing emulsion with a syringe pump at a rate of 6 mL/h. The final emulsion was probe-sonicated in an ice bath (50 s pulses on and 10 s off
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Published 13 Mar 2025

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

  • Naths Grazia Sukubo,
  • Paolo Bigini and
  • Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

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Published 31 Jan 2025

Nanomedicines against Chagas disease: a critical review

  • Maria Jose Morilla,
  • Kajal Ghosal and
  • Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

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  • the cumulative dose of BNZ would reduce its toxicity without losing effectiveness [48], BNZ has recently been formulated as nanocrystals (NCs). The solubility of BNZ formulated as nanocrystals prepared by nanoprecipitation using the non-ionic surfactant poloxamer 188 as a stabilizer (BNZ-NC) was
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Published 27 Mar 2024

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

  • Giuliana Muraca,
  • María Esperanza Ruiz,
  • Rocío C. Gambaro,
  • Sebastián Scioli-Montoto,
  • María Laura Sbaraglini,
  • Gisel Padula,
  • José Sebastián Cisneros,
  • Cecilia Yamil Chain,
  • Vera A. Álvarez,
  • Cristián Huck-Iriart,
  • Guillermo R. Castro,
  • María Belén Piñero,
  • Matias Ildebrando Marchetto,
  • Catalina Alba Soto,
  • Germán A. Islan and
  • Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

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  • bioavailability by modifying the absorption, distribution, and elimination of the drug. In this study, BNZ was successfully loaded into nanocarriers composed of myristyl myristate/Crodamol oil/poloxamer 188 prepared by ultrasonication. A stable NLC formulation was obtained, with ≈80% encapsulation efficiency (%EE
  • bulk material, considering the disarrangement caused by the incorporation of the drug and the surfactant. For that reason, it might require less energy to melt in comparison to the pure crystalline substance [25]. Thermogravimetric curves of myristyl myristate, poloxamer 188, and BNZ showed one thermal
  • degradation process, whereas NLC-BNZ and NLC-VEHICLE presented two events (Figure 3). That was also observed in the derivative curves. The weight loss process for the lipid started at 180 °C and finished at 320 °C. The poloxamer 188 thermogram showed a decomposition process starting at 300 °C and ending at
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Published 28 Jul 2023

Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading

  • Agnes-Valencia Weiss,
  • Daniel Schorr,
  • Julia K. Metz,
  • Metin Yildirim,
  • Saeed Ahmad Khan and
  • Marc Schneider

Beilstein J. Nanotechnol. 2022, 13, 778–787, doi:10.3762/bjnano.13.68

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  • ), Poloxamer 188 (Kolophor® P 188), 25% glutaraldehyde solution, branched polyethylene imine (25 kDa, PEI), sodium metabisulfite, trinitrobenzenesulfonic acid 5% in methanol, sodium hydrogen carbonate, lysozyme from chicken egg white, and solvents (HPLC grade) have been obtained from Sigma-Aldrich (Steinheim
  • nanoprecipitation method described in [17]. In brief, 20 mg gelatin was dissolved in 1 mL of deionized water at 50 °C and added to the antisolvent phase, consisting of 2.8% poloxamer 188 dissolved in a mixture of acetone and deionized water in a ratio of 15:1, with an injection rate of 0.25 mL/min using a syringe
  • ] with sodium metabisulfite, which forms a complex with glutaraldehyde, thus, terminating the crosslinking process [23]. The complex, unreacted material, and excess poloxamer 188 were removed by purification via tangential flow filtration (Minimate TFF capsule, 300 kDa, Pall Corporation, Port Washington
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Published 16 Aug 2022

Design and characterization of polymeric microneedles containing extracts of Brazilian green propolis

  • Camila Felix Vecchi,
  • Rafaela Said dos Santos,
  • Jéssica Bassi da Silva and
  • Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2022, 13, 503–516, doi:10.3762/bjnano.13.42

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  • taken orally, the extracts have a strong and unpleasant taste. The aim of this work was to fabricate and characterize microneedles containing polyvinyl alcohol, polyvinylpyrrolidone, poloxamer P407, and an ethanolic or glycolic extract of PRP. Also, the obtained structures were microscopically and
  • and lower toxicity [26][27]. In our previous studies, polymeric systems composed of polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), and poloxamer 407 (P407) were obtained and characterized. P407 could improve structuring and rapid dispersion of polymeric matrices, which showed promising
  • regarding in vitro and in vivo evaluation of the biological activity and cytotoxicity of the MNs, the vitro PRP release profile, the cutaneous permeation using porcine and human skin, and photoacoustic spectroscopy. Experimental Materials Poloxamer 407 (P407), gelatin, and propylene glycol were purchased
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Published 08 Jun 2022

Use of nanosystems to improve the anticancer effects of curcumin

  • Andrea M. Araya-Sibaja,
  • Norma J. Salazar-López,
  • Krissia Wilhelm Romero,
  • José R. Vega-Baudrit,
  • J. Abraham Domínguez-Avila,
  • Carlos A. Velázquez Contreras,
  • Ramón E. Robles-Zepeda,
  • Mirtha Navarro-Hoyos and
  • Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

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  • -loaded polymeric (PNP with PLGA) and lipid nanoparticles (SLN with hydrogenated coco-glycerides and poloxamer 188). They reported greater stability at 135 days (>90% retention), lower average particle size (127.10 ± 11.30 nm), and higher EE% (90.49 ± 1.20%) in CUR-SL, as compared to CUR-PNP (338.20
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Published 15 Sep 2021

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

  • Nikola Geskovski,
  • Nadica Matevska-Geshkovska,
  • Simona Dimchevska Sazdovska,
  • Marija Glavas Dodov,
  • Kristina Mladenovska and
  • Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

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  • ). Illum and Davis were among the first researchers that reported on the possibility of guiding colloidal particles to the BM [21]. The initial goal of the group was to evaluate the effects of different PEO–PPO-based hydrophilic copolymer (poloxamer) shells upon the biodistribution, primarily the
  • circulation half-life of polystyrene colloidal particles [21][22]. In their experiments, besides the groundbreaking work on the steric barrier and the so-called “stealth” effect of the poloxamer, they have further noticed that the adsorbed poloxamer 338 and 407 shells directed the polystyrene beads to the
  • sinusoidal endothelial cells of rabbit BM [23]. Even though the authors eliminated the possibility of a BM distribution mediated through macrophage phagocytosis, the exact mechanism of localization remained unknown. Moreover, the poloxamer-coated polystyrene beads circulated in the blood for up to eight days
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Published 29 Apr 2021

Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms

  • Mykola Borzenkov,
  • Piersandro Pallavicini,
  • Angelo Taglietti,
  • Laura D’Alfonso,
  • Maddalena Collini and
  • Giuseppe Chirico

Beilstein J. Nanotechnol. 2020, 11, 1134–1146, doi:10.3762/bjnano.11.98

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  • microorganisms with limited cytotoxicity. In another recent publication, the photothermal effect of phospholipid-coated gold nanorods loaded into a poloxamer 407 hydrogel resulted in ≈4.5–5 log cycle reduction in the viable counts of a P. aeruginosa biofilm in comparison to the control sample [55]. The authors
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Published 31 Jul 2020

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

  • Maria Suciu,
  • Corina M. Ionescu,
  • Alexandra Ciorita,
  • Septimiu C. Tripon,
  • Dragos Nica,
  • Hani Al-Salami and
  • Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

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  • , dendrimers, albumin, silicones, liposomes, poloxamer, poly-ʟ-lysine, sugars, or polyethylene glycol (PEG) [27][28][29][30][31][32][33]. Hyperthermia treatment for cancer therapy is still under scrutiny. It shows great potential due to the property of SPIONs to produce local heat when placed under an
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Published 27 Jul 2020

Key for crossing the BBB with nanoparticles: the rational design

  • Sonia M. Lombardo,
  • Marc Schneider,
  • Akif E. Türeli and
  • Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

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  • 20, 40, 60 and 80, poloxamer 184, 188, 388, 407 and 908, Brij® 35 and Cremophors® EZ and RH. Only PBCA nanoparticles coated with polysorbates showed a significant analgesic effect, and the highest effect was obtained for PS80-coated nanoparticles. Further studies showed that PS80 did not cause any
  • on uncoated nanoparticles or nanoparticles coated with poloxamer 338 and 407, Cremophor® EL or Cremophor® RH40. Building on this work and to study the mechanism behind the transcytosis of PBCA nanoparticles, dalargin-loaded PBCA nanoparticles were coated with apolipoproteins A-II, B, C-II, E and J
  • selectively in the blood and cross the BBB through RMT by interacting with LDL receptors present on the luminal side of brain endothelial cells. In another study by Kreuter’s team, PBCA nanoparticles loaded with doxorubicin and coated with either PS80 or poloxamer 188 (P188) could increase the survival of
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Published 04 Jun 2020

Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects

  • Sabrina Barbosa de Souza Ferreira,
  • Gustavo Braga,
  • Évelin Lemos Oliveira,
  • Jéssica Bassi da Silva,
  • Hélen Cássia Rosseto,
  • Lidiane Vizioli de Castro Hoshino,
  • Mauro Luciano Baesso,
  • Wilker Caetano,
  • Craig Murdoch,
  • Helen Elizabeth Colley and
  • Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222

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  • , The University of Sheffield, Sheffield, UK 10.3762/bjnano.10.222 Abstract Mucoadhesive nanostructured systems comprising poloxamer 407 and Carbopol 974P® have already demonstrated good mucoadhesion, as well as improved mechanical and rheological properties. Curcumin displays excellent biological
  • selectivity targeting cancer cells. Keywords: curcumin; mucoadhesion; oral squamous cell carcinoma; permeation; poloxamer 407; Introduction The development of nanostructured systems containing poloxamer 407 (P407) and Carbopol 974P® (C974P) have previously been shown to have rheological and mechanical
  • studies should be performed in tissue-engineered and in vivo models in order to test the performance of these systems in a more complex environment. Experimental Materials Curcumin (>98% purity), poloxamer 407 and mucin from porcine stomach type II were purchased from Sigma-Aldrich (St. Louis, MO, USA
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Published 25 Nov 2019

Microfluidics as tool to prepare size-tunable PLGA nanoparticles with high curcumin encapsulation for efficient mucus penetration

  • Nashrawan Lababidi,
  • Valentin Sigal,
  • Aljoscha Koenneke,
  • Konrad Schwarzkopf,
  • Andreas Manz and
  • Marc Schneider

Beilstein J. Nanotechnol. 2019, 10, 2280–2293, doi:10.3762/bjnano.10.220

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  • , Germany) and poly(lactic-co-glycolic acid) (PLGA) (Resomer RG 503 H, 50:50 ratio, average Mw = 24,000–38,000 Da) was obtained from Evonik Industries (Darmstadt, Germany). Amphiphilic block copolymer Poloxamer (Pluronic F68, F127, 9400, 6200, 3100, 10500 and 6400) was a kind gift from BASF SE (Ludwigshafen
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Published 19 Nov 2019

Preservation of rutin nanosuspensions without the use of preservatives

  • Pascal L. Stahr and
  • Cornelia M. Keck

Beilstein J. Nanotechnol. 2019, 10, 1902–1913, doi:10.3762/bjnano.10.185

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  • freeze–thaw method is suitable for the production of long-term stable non-preserved nanosuspensions with high microbial quality, previously developed nanosuspensions containing the flavonoid rutin as model substance and either Plantacare 2000 or Poloxamer 188 (PLX 188) as stabilizers were produced by
  • the Poloxamer-stabilized formulations, which possessed a narrower size distribution, i.e., no agglomerates at the day of production (c.f. Table 2), were found to be more stable than the Plantacare-stabilized formulations with a broader size distribution due to a slight agglomeration of the
  • , whereas Plantacare-stabilized formulations remained stable. Reasons for the differences might be the different stabilizers that interact differently with the preservative. Poloxamer 188 is a non-ionic surfactant, providing steric stabilization for the nanocrystals. In general, a thick surfactant layer
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Published 19 Sep 2019

Lipid nanostructures for antioxidant delivery: a comparative preformulation study

  • Elisabetta Esposito,
  • Maddalena Sguizzato,
  • Markus Drechsler,
  • Paolo Mariani,
  • Federica Carducci,
  • Claudio Nastruzzi,
  • Giuseppe Valacchi and
  • Rita Cortesi

Beilstein J. Nanotechnol. 2019, 10, 1789–1801, doi:10.3762/bjnano.10.174

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  • oxide) (27) (poloxamer 188) was a gift from BASF ChemTrade GmbH (Burgbernheim, Germany). Miglyol 812 N, caprylic/capric triglycerides (miglyol) was a gift of Cremer Oleo Division (Witten, Germany). Glyceryl distearate (precirol ATO5, precirol), glyceryl dibehenate (compritol 888ATO, compritol) and mono
  • nanoparticles Lipid nanoparticles were prepared by a hot homogenization technique based on ultrasound treatment. In both cases the dispersing phase was an aqueous solution of poloxamer 188 (2.5% w/w) [37]. In the case of SLN the disperse phase was constituted of one solid lipid (i.e., tristearin, precirol
  • dispersion acronyms and compositions are reported in Table 1 and Table 2. Firstly, an emulsion was obtained adding the poloxamer 188 aqueous phase (4.5/4.75 mL) heated at 80 °C to the molten lipid phase (250/500 mg), followed by mixing at 15000 rpm, at 80 °C for 1 min (IKA T25 digital ultraturrax). Secondly
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Published 29 Aug 2019

Multiwalled carbon nanotube hybrids as MRI contrast agents

  • Nikodem Kuźnik and
  • Mateusz M. Tomczyk

Beilstein J. Nanotechnol. 2016, 7, 1086–1103, doi:10.3762/bjnano.7.102

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  • vivo studies. It is not clear whether the polyether chains of the poloxamer Pluronic® served as a non-ionic wrapping agent securing solid anchoring of the MWCNTs on the cell membrane [23][24]. Alternatively, its role might be more focused on stabilizing a disperse system by preventing the CNTs from
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Published 27 Jul 2016
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