Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

Electrospun nanofibers: building blocks for the repair of bone tissue

• Tuğrul Mert Serim,
• Gülin Amasya,
• Tuğba Eren-Böncü,
• Ceyda Tuba Şengel-Türk and
• Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

• scaffolds containing poly(ε-caprolactone) developed by Stellenbosch Nanofiber Company are used in tissue regeneration [104]. Patents regarding polymeric nanofibers used in bone regeneration The patent search database https://worldwide.espacenet.com/ of the European Patent Office lists 700 results for the

Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material

• Veronika Pálos,
• Krisztina S. Nagy,
• Rita Pázmány,
• Krisztina Juriga-Tóth,
• Bálint Budavári,
• Judit Domokos,
• Dóra Szabó,
• Ákos Zsembery and
• Angela Jedlovszky-Hajdu

Beilstein J. Nanotechnol. 2024, 15, 781–796, doi:10.3762/bjnano.15.65

• Polymer mixtures contain at least one component besides the polymer, such as nanoparticles, inorganic salts, or other polymers. These types of polymer mixtures are used for medical purposes; for example, metronidazole/poly(ε-caprolactone) (PCL)/alginate for dental implants or poly(lactic acid

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• of a polycaprolactone (PCL) core, a mixed poly(2-dimethylamino)ethyl methacrylate/poly(ethylene oxide) (PDMAEMA(TPP+)/PEO) middle layer, and a PEO corona. The system was self-assembled using poly(ethylene oxide)-poly(ε-caprolactone)-b-poly(ethylene oxide) (PEO113-b-PCL70-b-PEO113) and poly(2

• -(dimethylamino)ethyl methacrylate)-b-poly(ε-caprolactone)-b-poly(2-(dimethylamino)ethyl methacrylate (PDMAEMA20(TPP+)-b-PCL70-b-PDMAEMA20(TPP+)) block copolymers. PEO-PCL blocks were linked using acetal groups to enable the cleavage of the PEO blocks from the NP surface in the acidic environment of a tumor and

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• addition of Gd3+ ions (magnetic resonance imaging, MRI) or 64Cu2+ (positron emission tomography, PET). A pH-sensitive acetal bond between poly(ε-caprolactone) and porphyrin was used to release porphyrin at pH 5 (Figure 5c) [79]. In a poly(ethylene glycol)-block-poly(ε-caprolactone) polymer conjugated with

Mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) as multivalent lectin-binding nanomaterials

• Stefania Ordanini,
• Wanda Celentano,
• Anna Bernardi and
• Francesco Cellesi

Beilstein J. Nanotechnol. 2019, 10, 2192–2206, doi:10.3762/bjnano.10.212

• , Università degli Studi di Milano, via Golgi 19, Milano 20133, Italy 10.3762/bjnano.10.212 Abstract A class of linear and four-arm mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) is presented here. The synthesis through ring-opening and atom transfer radical

• : atom transfer radical polymerization (ATRP); glycopolymer; lectin; poly(ethylene glycol); poly(ε-caprolactone); ring-opening polymerization (ROP); Introduction Carbohydrate–protein interactions are involved in many biological processes, including cell recognition and cell–cell adhesion. These

• -functionalized monomer, starting from a four-arm initiator based on poly(ε-caprolactone), led to a library of glucose-functionalized aggregates able to bind the glucose- and mannose-binding lectin Concanavalin A (Con A) [12]. The combination of ATRP of protected alkyne monomers and a copper-catalyzed azide

Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

• Aniela Bittner,
• Angélique D. Ducray,
• Hans Rudolf Widmer,
• Michael H. Stoffel and
• Meike Mevissen

Beilstein J. Nanotechnol. 2019, 10, 941–954, doi:10.3762/bjnano.10.95

• and specialized structures such as the blood–brain barrier (BBB). To be able to safely employ LTS in nanomedicine, such unwanted effects need to be studied. Previously, we investigated effects of silica (Si-), namely silica-ICG/poly(ε-caprolactone) (PCL) and silica-ICG/poly(ε-caprolactone-poly(L

• , UK) at 37 °C and 5% CO2. Nanoparticles Silica-ICG/poly(ε-caprolactone) (PCL) and silica-ICG/poly(ε-caprolactone-poly(L-lactide) (PLLA) NPs were constructed and provided by Prof. Dr. Uwe Pieles, Department of Chemistry and Bioanalytics, Academy of Life Science, Switzerland. Both types of NPs consisted

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

• Qura Tul Ain,
• Samina Hyder Haq,
• Abeer Alshammari,
• Moudhi Abdullah Al-Mutlaq and
• Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

• ) [5], poly(ε-caprolactone) (PCL) [6], hydroxypropyl-β-cyclodextrin (HPCD) [7], and poly(L-lactic acid) (PLLA) [8]. Biocompatible GO has many prospective uses in tissue engineering [9], drug delivery [10], cancer therapy [11][12], and treatment of bacterial infections [13][14]. Dinescu et al. designed

Effect of electrospinning process variables on the size of polymer fibers and bead-on-string structures established with a 2³ factorial design

• Paulina Korycka,
• Adam Mirek,
• Katarzyna Kramek-Romanowska,
• Marcin Grzeczkowicz and
• Dorota Lewińska

Beilstein J. Nanotechnol. 2018, 9, 2466–2478, doi:10.3762/bjnano.9.231

• vascular grafts made of poly(ε-caprolactone) electrospun nanofibers [27]. However, works on the implementation of the factorial design to describe bead-on-string structures have not been conducted yet. All of the dependencies, described in the abovementioned studies, are usually established empirically and

Nanoconjugates of a calixresorcinarene derivative with methoxy poly(ethylene glycol) fragments for drug encapsulation

• Alina M. Ermakova,
• Julia E. Morozova,
• Yana V. Shalaeva,
• Victor V. Syakaev,
• Aidar T. Gubaidullin,
• Alexandra D. Voloshina,
• Vladimir V. Zobov,
• Irek R. Nizameev,
• Olga B. Bazanova,
• Igor S. Antipin and
• Alexander I. Konovalov

Beilstein J. Nanotechnol. 2018, 9, 2057–2070, doi:10.3762/bjnano.9.195

• the NMR time scale and, consequently, to the broadening of the signals of calixresorcinarene platform in the NMR spectra. The same broadening in the spectra of tetraundecylcalix[4]resorcinarene with poly-ε-caprolactone fragments on the upper rim was described earlier [22]. In the FTIR spectrum of 3

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• film formulations as post-surgical local delivery systems for docetaxel (DOC). PCL and its derivative poly(ethylene glycol)-block-poly(ε−caprolactone) methyl ether (mePEG-PCL) were used to prepare these nanoparticles by the nanoprecipitation technique with surface modification by coating with CS. The

Intercalation and structural aspects of macroRAFT agents into MgAl layered double hydroxides

• Dessislava Kostadinova,
• Ana Cenacchi Pereira,
• Muriel Lansalot,
• Franck D’Agosto,
• Elodie Bourgeat-Lami,
• Fabrice Leroux,
• Christine Taviot-Guého,
• Sylvian Cadars and
• Vanessa Prevot

Beilstein J. Nanotechnol. 2016, 7, 2000–2012, doi:10.3762/bjnano.7.191

• ], elastomers [27], epoxy polymers [28], poly(ε-caprolactone) [29], polyesters [30], polyurethane [31] and polyimide [21]. Alternatively, Leroux et al. described the preparation of a hybrid LDH phase intercalated by an anionic polymerizable surfactant acting further as an anchor that compatibilizes the

Fabrication and characterization of novel multilayered structures by stereocomplexion of poly(D-lactic acid)/poly(L-lactic acid) and self-assembly of polyelectrolytes

• Elena Dellacasa,
• Li Zhao,
• Gesheng Yang,
• Laura Pastorino and
• Gleb B. Sukhorukov

Beilstein J. Nanotechnol. 2016, 7, 81–90, doi:10.3762/bjnano.7.10

• well as other biocompatible polymers such as poly(methyl methacrylate) (PMMA) [39][40][41], poly(lactic-co-glycolic acid) (PLGA) [42] and poly-ε-caprolactone (PCL) [43][44], is extremely interesting for the fabrication of innovative multilayer structures to be used in drug delivery applications. In

Nanoscale rippling on polymer surfaces induced by AFM manipulation

• Mario D’Acunto,
• Franco Dinelli and
• Pasqualantonio Pingue

Beilstein J. Nanotechnol. 2015, 6, 2278–2289, doi:10.3762/bjnano.6.234

• wide spectrum of polymers has been investigated including polystyrene (PS) [13][20], poly(methyl methacrylate) (PMMA) [25], poly(ethylene terephthalate) (PET) [23], poly(vinyl acetate) (PVAc) [26] and poly(ε-caprolactone) (PCL) [23]. Recently, we have reviewed wear occurring on polymeric surfaces and

Oxygen-plasma-modified biomimetic nanofibrous scaffolds for enhanced compatibility of cardiovascular implants

• Anna Maria Pappa,
• Varvara Karagkiozaki,
• Silke Krol,
• Spyros Kassavetis,
• Dimitris Konstantinou,
• Charalampos Pitsalidis,
• Lazaros Tzounis,
• Nikos Pliatsikas and
• Stergios Logothetidis

Beilstein J. Nanotechnol. 2015, 6, 254–262, doi:10.3762/bjnano.6.24

• complications of thrombosis and implant failure. Thus, we herein fabricated poly-ε-caprolactone (PCL) electrospun nanofibrous scaffolds, to serve as coatings for cardiovascular implants and guide tissue regeneration. Oxygen plasma treatment was applied in order to modify the surface chemistry of the scaffold

Cyclodextrin-poly(ε-caprolactone) based nanoparticles able to complex phenolphthalein and adamantyl carboxylate

• Daniela Ailincai and
• Helmut Ritter

Beilstein J. Nanotechnol. 2014, 5, 651–657, doi:10.3762/bjnano.5.76

• Chemie, Geb. 26.33, Eb. 00, Universitätsstr. 1, 40225 Düsseldorf, Germany 10.3762/bjnano.5.76 Abstract A new compound composed of poly(ε-caprolactone) and β-cyclodextrin (β-CD) was synthesized by click chemistry. This compound was used to obtain stable nanoparticles, which have been proven to be able to

• studied and used is poly(ε-caprolactone), a linear aliphatic polyester, obtained by ring-opening polymerization of ε-caprolactone. Poly(ε-caprolactone) was used in several combinations, including click reaction products. Functionalized polyester was obtained, which was further used for grafting β-CD on it

• . The final product has been proven to exhibit a host–guest ability with different compounds [7]. Pseudo-polyrotaxanes based on propargyl functionalized poly(ε-caprolactone) and mono-(6-azido-6-desoxy)-ß-CD have been successfully obtained [8]. Here, we propose to obtain an amphiphilic behavior by using