Development of a mucoadhesive drug delivery system and its interaction with gastric cells

• Ahmet Baki Sahin,
• Serdar Karakurt and
• Deniz Sezlev Bilecen

Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28

• , positively charged nanoparticles have more potential to induce adherence to the mucus layer [43]. Thus, for this study, Eudragit RS100 polymer was chosen as a coating polymer to obtain positively charged nanoparticles. Upon coating the Alg nanoparticles, the zeta potential shifted to positive values (39.72

Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles

• Rouhollah Khodadust,
• Ozlem Unal and
• Havva Yagci Acar

Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6

• polypeptic nanoparticles (10–100 nm), which are capable of being absorbed by endocytosis [50][51]. The gel retardation of poly I:C (dsRNA analogue) happens after interacting with positively charged nanoparticles. According to our gel electrophoresis results and comparing between free poly I:C (well 8), at an

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• worked on three cell types, i.e., heart, kidney, and brain cell lines, with bare SPIONs and SPIONs with negative or positive surface charge. They showed that positively charged nanoparticles are highly toxic and that each cell type responds differently to every type of nanoparticles, genetically

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• also have an impact on the BBB crossing ability of nanoparticles. Nanoparticles expressing positive charges on their surface can cross the BBB through AMT. However, positively charged nanoparticles have a faster plasma clearance rate, which lowers their residence time in brain microvessels and

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

• Valentina Francia,
• Daphne Montizaan and
• Anna Salvati

Beilstein J. Nanotechnol. 2020, 11, 338–353, doi:10.3762/bjnano.11.25

• ]. Nanoparticle charge: Apart from size, charge is another easily tunable parameter that can greatly influence the behaviour of nanoparticles in biological media [135] and on cells [136]. In general, positively charged nanoparticles seem to be internalized more efficiently than neutral and negatively charged

Uptake and intracellular accumulation of diamond nanoparticles – a metabolic and cytotoxic study

• Antonín Brož,
• Lucie Bačáková,
• Pavla Štenclová,
• Alexander Kromka and
• Štěpán Potocký

Beilstein J. Nanotechnol. 2017, 8, 1649–1657, doi:10.3762/bjnano.8.165

• attractive for binding to the cell membrane than positively charged nanoparticles, which can be internalized more rapidly [44]. Positively charged nanoparticles have been reported to improve the efficacy of imaging, gene transfer and drug delivery. However, at the same time, negative effects like impaired

• integrity of cytoplasmic membrane and damage of other membranous organelles like mitochondria and lysosomes were observed. Also, more autophagosomes were produced by the cells cultivated with positively charged nanoparticles ([45] or for a review see [46]). Hydrogenated positively charged ND particles

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• cells can be clearly seen in Figure 8. Anticancer activity increases with increasing surface charge of nanoparticles. It was known that the cell membrane is negatively charged so that cationic nanoparticles enhance interaction with the biological membrane. Positively charged nanoparticles can bind with

Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles

• Olga Rotan,
• Katharina N. Severin,
• Simon Pöpsel,
• Alexander Peetsch,
• Melisa Merdanovic,
• Michael Ehrmann and
• Matthias Epple

Beilstein J. Nanotechnol. 2017, 8, 381–393, doi:10.3762/bjnano.8.40

• showed only a very low uptake of these anionic nanoparticles (Figure 4). Table 4 summarizes all results of the uptake experiments, including those with cationic CaP/PEI and anionic CaP/CMC nanoparticles (i.e., without proteins). It has been frequently reported that positively charged nanoparticles are

Ultrastructural changes in methicillin-resistant Staphylococcus aureus induced by positively charged silver nanoparticles

• Dulce G. Romero-Urbina,
• Humberto H. Lara,
• J. Jesús Velázquez-Salazar,
• M. Josefina Arellano-Jiménez,
• Eduardo Larios,
• Anand Srinivasan,
• Jose L. Lopez-Ribot and
• Miguel José Yacamán

Beilstein J. Nanotechnol. 2015, 6, 2396–2405, doi:10.3762/bjnano.6.246

• aureus. Future research should focus on defining the related molecular mechanisms and their importance to the antimicrobial activity of silver nanoparticles. Keywords: electron microscopy; methicillin-resistant Staphylococcus aureus (MRSA); positively charged nanoparticles; silver nanoparticles

Comparative evaluation of the impact on endothelial cells induced by different nanoparticle structures and functionalization

• Lisa Landgraf,
• Ines Müller,
• Peter Ernst,
• Miriam Schäfer,
• Christina Rosman,
• Isabel Schick,
• Oskar Köhler,
• Hartmut Oehring,
• Vladimir V. Breus,
• Thomas Basché,
• Carsten Sönnichsen,
• Wolfgang Tremel and
• Ingrid Hilger

Beilstein J. Nanotechnol. 2015, 6, 300–312, doi:10.3762/bjnano.6.28

• surface functionalization and had the highest impact on the cell viability for the positively charged QDs. These findings confirmed the results of previous studies and further reinforce the fact that the cytotoxicity of positively charged nanoparticles is mainly due to impairment of cellular membranes

Tailoring the ligand shell for the control of cellular uptake and optical properties of nanocrystals

• Johannes Ostermann,
• Christian Schmidtke,
• Christopher Wolter,
• Jan-Philip Merkl,
• Hauke Kloust and
• Horst Weller

Beilstein J. Nanotechnol. 2015, 6, 232–242, doi:10.3762/bjnano.6.22

• charged counterparts. However, this is in good agreement with literature findings concerning the uptake of positively charged nanoparticles [35][41]. Interestingly, a reverse size-dependent effect for the negatively charged nanocontainers was observed. While the smaller samples showed no interaction with

Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions

• Cornelia Loos,
• Tatiana Syrovets,
• Anna Musyanovych,
• Volker Mailänder,
• Katharina Landfester,
• G. Ulrich Nienhaus and
• Thomas Simmet

Beilstein J. Nanotechnol. 2014, 5, 2403–2412, doi:10.3762/bjnano.5.250

• about four times more negatively charged nanoparticles in cell culture medium. By contrast, monocytic leukemia cells, internalized more rapidly positively charged nanoparticles independently of the assay media. The ability of macrophages to preferentially internalize negatively charged nanoparticles

Inorganic Janus particles for biomedical applications

• Isabel Schick,
• Steffen Lorenz,
• Dominik Gehrig,
• Stefan Tenzer,
• Wiebke Storck,
• Karl Fischer,
• Dennis Strand,
• Frédéric Laquai and
• Wolfgang Tremel

Beilstein J. Nanotechnol. 2014, 5, 2346–2362, doi:10.3762/bjnano.5.244

• introducing amino-groups at the surface [108][109]. The resulting positively charged nanoparticles are known to be taken up more efficiently in in vitro cultures [110][111], whereby amine-functionalized silica-particles enable covalent conjugation of dyes, biomolecules, such as sugars, antibodies, and