Development of a mucoadhesive drug delivery system and its interaction with gastric cells

• Ahmet Baki Sahin,
• Serdar Karakurt and
• Deniz Sezlev Bilecen

Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28

• site. In situ mucoadhesion studies The ability of nanoparticles to stick to mucus, known as mucoadhesion, is important for retention at mucus-bearing sites and, thus, prolonged drug release into the environment [52]. The mucus interaction of the EudAlg NPs was first studied by DLS measurements, where

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• resulted in prolonged drug release due to the delayed penetration of water into the polymer scaffolds. The change in the water contact angle of PLA nanofiber scaffolds loaded with BBR powder and BBR NPs is presented in Table 1. The PLA nanofiber scaffold possessed typical hydrophobic property with a water

Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics

• Sedat Ünal,
• Osman Doğan and
• Yeşim Aktaş

Beilstein J. Nanotechnol. 2022, 13, 1393–1407, doi:10.3762/bjnano.13.115

• preserve a DCX amount of about 60% and a substantial amount of DCX was released at the colonic pH values. It is known that surface modification with CS provides a prolonged drug release profile to NP [51][52]. In vitro evaluation of nanoparticle interaction with mucus Orally administered drug molecules

Microneedle-based ocular drug delivery systems – recent advances and challenges

• Piotr Gadziński,
• Anna Froelich,
• Monika Wojtyłko,
• Antoni Białek,
• Julia Krysztofiak and
• Tomasz Osmałek

Beilstein J. Nanotechnol. 2022, 13, 1167–1184, doi:10.3762/bjnano.13.98

• scaffold to increase the matrix stability and to provide prolonged drug release. It was observed that the patches penetrated the rabbit corneal epidermis without irritation and, after removal, total recovery was observed after 12 h. The developed patch showed great potential as an alternative to ocular

Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects

• Çiğdem Yücel,
• Gökçe Şeker Karatoprak,
• Sena Yalçıntaş and
• Tuğba Eren Böncü

Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41

• kept in the skin for a longer period of time and penetrate into deeper layers. In a study by Fathalla et al., the gel-based formulations tested, especially with the ETH-based gel system, showed prolonged drug release in the treatment and yielded more successful results in the permeation study in rats

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

• an ideal drug loading capacity (38.44%) and prolonged drug release [69]. The results showed that the curcuminoid-loaded HA-CNPs suppressed the NF-kB pathway and decreased the expression of MMP-1 and MMP-13 while increasing the expression of type-II collagen in a knee OA chondrocyte model. Furthermore

A visible-light-controlled platform for prolonged drug release based on Ag-doped TiO₂ nanotubes with a hydrophobic layer

• Caihong Liang,
• Jiang Wen and
• Xiaoming Liao

Beilstein J. Nanotechnol. 2018, 9, 1793–1801, doi:10.3762/bjnano.9.170

• Caihong Liang Jiang Wen Xiaoming Liao College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China 10.3762/bjnano.9.170 Abstract In this work, a visible-light-controlled drug release platform was constructed for localized and prolonged drug release based on two

• exhibit promising application as a localized, prolonged drug delivery platform. Keywords: Ag doping; drug delivery; hydrophobic layer; prolonged drug release; TiO2 nanotubes; visible-light-controlled release; Introduction Titanium dioxide nanotubes (TNTs) are often employed as drug carriers, owing to

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• . Nanoparticle-based drug delivery systems can be prepared with synthetic and natural polymers. As an advantage, their surface properties can be modified to increase cellular penetration and prolonged drug release. Additionally, suitable nanoparticle-based drug delivery systems can bypass biological barriers or