Search results
Search for "quality by design" in Full Text gives 5 result(s) in Beilstein Journal of Nanotechnology.
Breaking barriers: nanosystems to overcome solubility and permeability challenges of second-generation tyrosine kinase inhibitors
Beilstein J. Nanotechnol. 2026, 17, 1063–1086, doi:10.3762/bjnano.17.73
- stability, scalability, and feasibility for clinical transition. Keywords: BCS class-IV; bioavailability enhancement; biopharmaceutical limitation; bosutinib; dasatinib; drug delivery system; nanosystems; nilotinib; quality by design; second-generation TKI; Introduction Tyrosine kinases have emerged as
- DTB that have been explored recently, along with quality by design (QbD), regulatory challenges, translational status, and emerging trends in this class of drugs. Review Literature research methodology The process of the literature search is depicted in Figure 2. The literature included in this review
Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil
Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146
- poor physicochemical and organoleptic properties. This study aimed to develop and optimize a topical microemulsion (ME) system incorporating P. setacea seed oil using quality by design principles to address formulation challenges. The oil was extracted via Soxhlet and characterized by gas
- assays demonstrated high cell viability for ME at concentrations below 2 mg/mL in RAW 264.7 macrophages and 0.5 mg/mL in human umbilical vein endothelial cells. Overall, this work presents a promising nanotechnology-based topical delivery platform for P. setacea seed oil, employing quality by design
- principles to ensure formulation performance, stability, and skin cell compatibility. Keywords: design of experiments (DoE); microemulsions; nanotechnology; natural products; passion fruit; quality by design; skin delivery; Introduction Species of the Passiflora genus are known for their rich composition
Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects
Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118
- against MDA-MB-435s cells. Further, the targeted PLHNPs also showed better cytotoxic effects against MCF-7 cells. In another study, Ma et al. fabricated HCT-loaded PEGylated PLHNPs and optimized them by the “Quality by Design” approaches such as Plackett–Burman and Box–Behnken designs [127]. The developed
- CHS-based mucoadhesive PLHNPs in improving PRN’s intestinal permeation, oral bioavailability, and anti-BC activity [154]. The developed PLHNPs were optimized by the “Quality by Design” approach. The optimized PRN-PLHNPs were stable in the GI milieu and showed excellent mucoadhesive strength and
Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent
Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46
- increasingly pursued “quality by design” criteria [24]. The development of structurally simple formulations that facilitate their scaling and further characterization is, therefore, a critical task [25]. Also, targeting nanomedicines to circulating cells and vascular walls is difficult since it should occur
Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems
Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42
- smaller particle size. In addition, we used Quality by design (QbD) to generate parameters that can be applied to commercial products in the future. The QbD is a systematic approach to drug development that ensures that a product is of high quality and consistently meets the desired characteristics
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