When nanomedicines meet tropical diseases

• Eder Lilia Romero,
• Katrien Van Bocxlaer and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 830–832, doi:10.3762/bjnano.15.69

• ; Chagas disease; leishmaniasis; nanomedicine; nanotechnology; neglected tropical diseases; schistosomiasis; In May 2021, the World Health Assembly from the World Health Organization (WHO) decided to officially recognize January 30th as the World Neglected Tropical Diseases Day. This initiative was done

• approach against leishmaniasis [4]. Dourado and collaborators, who showed the therapeutic potential of curcumin-loaded nanocarriers, have also focused their review on these vector-borne NTDs [5]. With an emphasis on the treatment of schistosomiasis using nanoparticles, Carvalho and colleagues provided a

• comprehensive review on the field. Herein, the authors have accessed different databases, finding inorganic and polymeric nanoparticles as the most investigated nanosystems towards schistosomiasis, an acute and chronic parasitic NTD caused by blood-feeding nematodes of the genus Schistosoma [6]. Another

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• Technological Innovation Laboratory - Department of Physiological Sciences, Biomedical Institute, R. Frei Caneca, 94, Rio de Janeiro, Brazil 10.3762/bjnano.15.2 Abstract Schistosomiasis causes over 200,000 deaths annually. The current treatment option, praziquantel, presents limitations, including low

• bioavailability and resistance. In this context, nanoparticles have emerged as a promising option for improving schistosomiasis treatment. Several narrative reviews have been published on this topic. Unfortunately, the lack of clear methodologies presented in these reviews leads to the exclusion of many important

• ; nanoformulation; nanotechnology; neglected diseases; praziquantel; schistosoma; Introduction Schistosomiasis is a disease common in tropical countries caused by trematodes from the genus Schistosoma. More than 220 million people are affected by this disease, in addition to 800 million at risk of infection [1][2

A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization

• Gabriel M. Misirli,
• Kishore Sridharan and
• Shirley M. P. Abrantes

Beilstein J. Nanotechnol. 2021, 12, 440–461, doi:10.3762/bjnano.12.36

• used in the future against the increase of multidrug-resistant pathogenic strains. In addition, AgNPs can also be used to combat neglected diseases such as dengue, leishmaniasis, malaria, schistosomiasis, and trypanosomiasis (Chagas disease) among other applications [5][19][24]. The unprecedented

• toxicity and improved efficacy [86]. In vivo and in vitro studies have demonstrated the efficacy of AgNPs in treating neglected diseases, such as dengue [87][88], leishmaniasis [89][90][91][92], malaria [93][94][95], schistosomiasis [96][97], and trypanosomiasis (Chagas disease) [98][99]. Mechanism of