Beilstein J. Nanotechnol.2024,15, 1189–1196, doi:10.3762/bjnano.15.96
extremely useful for drug delivery and release. We analyzed the possibility to include the known antitumor drug doxorubicin (DOX), which has antimitotic and antiproliferative effects, in a nanopolymer complex. Thus, doxorubicin-loaded temperature- and pH-sensitive smartnanopolymers (DOX-SNPs) were produced
that observed for the commercial liposomal formulation of doxorubicin Doxil. The obtained results demonstrated that smartnanopolymers can be efficiently used to create new types of doxorubicin-based drugs.
Keywords: cancer cell line HeLa; cytotoxicity; doxorubicin; drug delivery; smartnanopolymers
structure with a low carrying capacity may not provide the desired effect. DOX loading of SNPs was conducted as previously mentioned in section “Preparation of DOX-SNPs”. The DOX-loading capacity of smartnanopolymers was investigated in the concentration range of 1–9 µM (5 mg SNPs in 5 mL 0.05 M phosphate
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Figure 1:
Solutions utilized during polymerization.