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Search for "smart nanopolymers" in Full Text gives 1 result(s) in Beilstein Journal of Nanotechnology.

Synthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers

  • Ömür Acet,
  • Pavel Kirsanov,
  • Burcu Önal Acet,
  • Inessa Halets-Bui,
  • Dzmitry Shcharbin,
  • Şeyda Ceylan Cömert and
  • Mehmet Odabaşı

Beilstein J. Nanotechnol. 2024, 15, 1189–1196, doi:10.3762/bjnano.15.96

Graphical Abstract
  • extremely useful for drug delivery and release. We analyzed the possibility to include the known antitumor drug doxorubicin (DOX), which has antimitotic and antiproliferative effects, in a nanopolymer complex. Thus, doxorubicin-loaded temperature- and pH-sensitive smart nanopolymers (DOX-SNPs) were produced
  • that observed for the commercial liposomal formulation of doxorubicin Doxil. The obtained results demonstrated that smart nanopolymers can be efficiently used to create new types of doxorubicin-based drugs. Keywords: cancer cell line HeLa; cytotoxicity; doxorubicin; drug delivery; smart nanopolymers
  • structure with a low carrying capacity may not provide the desired effect. DOX loading of SNPs was conducted as previously mentioned in section “Preparation of DOX-SNPs”. The DOX-loading capacity of smart nanopolymers was investigated in the concentration range of 1–9 µM (5 mg SNPs in 5 mL 0.05 M phosphate
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Published 26 Sep 2024
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