Development of a mucoadhesive drug delivery system and its interaction with gastric cells

• Ahmet Baki Sahin,
• Serdar Karakurt and
• Deniz Sezlev Bilecen

Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28

• , hydrogen bonding, disulfide bond formation, or physical entanglement of polymers within the mesh-like mucus structure [9][10]. Sodium alginate is a linear polysaccharide composed of 1,4-linked β-ᴅ-mannuronic acid and α-ʟ-guluronic acid residues. Alginate can be used to form porous matrix-type drug delivery

• carrier towards gastric sites. By loading the nanoparticles with different drugs proposed for several gastric diseases such as gastric ulcers, gastritis, bacterial infections, or cancer, the efficacy of treatments for the diseases might be elevated. Experimental Materials Sodium alginate (medium viscosity

• nanoparticles (Alg NPs) were prepared with a technique similar to the one used in [77]. Briefly, sodium alginate (1.35 mL of 0.5% w/v) and sunflower oil (6.75 g) containing Span 80 (405 µL) were emulsified at 30000 rpm for 5 min. The emulsion was then probe-sonicated in an ice bath (50 s pulses on and 10 s off

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• inspiration from lollipops, Wang et al. developed a multilayered sodium alginate–chitosan hydrogel sphere drug delivery system, which uses ZnO-modified biocarbon (ZnO-BC) to enhance the photothermal conversion performance [70]. The hydrogel ball is embedded under the conjunctiva through surgery. ZnO-BC can

Enhanced catalytic reduction through in situ synthesized gold nanoparticles embedded in glucosamine/alginate nanocomposites

• Chi-Hien Dang,
• Le-Kim-Thuy Nguyen,
• Minh-Trong Tran,
• Van-Dung Le,
• Nguyen Minh Ty,
• T. Ngoc Han Pham,
• Hieu Vu-Quang,
• Tran Thi Kim Chi,
• Tran Thi Huong Giang,
• Nguyen Thi Thanh Tu and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2024, 15, 1227–1237, doi:10.3762/bjnano.15.99

• [10][11][12]. Sodium alginate, derived from marine algae, consists of β-ᴅ-mannuronic acid and its stereoisomer α-ʟ-guluronic acid, forming a linear block copolymer with branched chains [13][14]. This biopolymer possesses metal-binding functional groups that readily cross-link through strong

• . While gelispheres enhance the physical and mechanical properties of sodium alginate, their poor solubility limits their applicability. Recently, an ionotropic gelation method has been developed to produce nanoparticles from gelispheres through interaction between oligosaccharides (e.g., cyclodextrins

• Materials The study utilized reagents and chemicals without additional purification. Glucosamine, gold(III) chloride, calcium acetate hydrate, sodium alginate, sodium tetrahydroborate, 2-nitrophenol, 4-nitrophenol, and methyl orange were procured from Acros Scientific (Belgium). Distilled water was used

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• drug delivery and sensing applications because of their properties. Sodium alginate is a biopolymer from the sea, and it is one of the most commonly utilized natural materials in several pharmaceutical applications such as smart delivery systems and sensors [11][19]. The chemical structure of alginate

• indicates that it belongs to the hydrogel family and is insoluble in water. Sodium alginate is an odorless, tasteless powder that can be white or yellowish. Alginate is a linear polymer composed of ᴅ-mannuronic acid (M) and ʟ-guluronic acid (G) residues [28]. Alginate can be an effective absorbent and

• ease discomfort. Gastric dressing occurs when sodium alginate and hydrochloric acid are combined in the stomach. Additionally, alginate can prevent obesity by lowering body weight [30]. All the qualities make sodium alginate indispensable for a wide range of applications in medicine and sensing. As a

Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity

• Nguyen Thi Thanh Tu,
• T. Lan-Anh Vo,
• T. Thu-Trang Ho,
• Kim-Phuong T. Dang,
• Van-Dung Le,
• Phan Nhat Minh,
• Chi-Hien Dang,
• Vinh-Thien Tran,
• Van-Su Dang,
• Tran Thi Kim Chi,
• Hieu Vu-Quang,
• Radek Fajgar,
• Thi-Lan-Huong Nguyen,
• Van-Dat Doan and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2023, 14, 781–792, doi:10.3762/bjnano.14.64

• reagents were purchased from Acros (Belgium): silver nitrate (AgNO3), methyl orange (MO), rhodamine B (RhB), calcium acetate hydrate, sodium alginate, and sodium tetrahydroborate (NaBH4). Lactose was obtained from Yong Da (China). The chemicals were used without additional purification. Distilled water was

• , an aqueous solution of calcium acetate (14.36 mL; 6.5 mg·mL−1) was slowly added dropwise into an aqueous solution of sodium alginate (40 mL; 7 mg·mL−1) under stirring for 1 h at 1200 rpm. The mixture was allowed to equilibrate overnight. Subsequently, the Alg/Ca2+ spheres were separated by

Nanoarchitectonics to entrap living cells in silica-based systems: encapsulations with yolk–shell and sepiolite nanomaterials

• Celia Martín-Morales,
• Jorge Fernández-Méndez,
• Pilar Aranda and
• Eduardo Ruiz-Hitzky

Beilstein J. Nanotechnol. 2023, 14, 522–534, doi:10.3762/bjnano.14.43

• biopolymer solution under stirring until the formation of a homogeneous system with a final concentration of sepiolite between 2% and 5%. The employed biopolymer solutions were sodium alginate (8% w/v) or chitosan (4% w/v). Depending on the desired material, different final concentrations of sepiolite

• grade commercial product (>95% purity). A SEM image of this sepiolite sample showing its characteristic microfibrous morphology is provided in Figure S3 (Supporting Information File 1). Chemical reagents such as LUDOX® TMA colloidal silica, potassium hydroxide pellets ≥85%, sodium silicate 37%, sodium

• alginate of medium viscosity, CaCl2·2H2O (99%), medium molecular weight chitosan, and BG-11 culture medium have been purchased from Sigma-Aldrich. Protamine sulfate and PBS buffer (biochemistry grade) have been supplied by Thermo Scientific. Commercial food-grade apple juice (Granini) without additives has

A comprehensive review on electrospun nanohybrid membranes for wastewater treatment

• Senuri Kumarage,
• Imalka Munaweera and
• Nilwala Kottegoda

Beilstein J. Nanotechnol. 2022, 13, 137–159, doi:10.3762/bjnano.13.10

• mixture of PVA, sodium alginate, and PEO with incorporated nano-sized ZSM5 zeolite, which contains hydroxy functional groups (HZSM5). The maximum adsorption values of Th4+ and U6+ ions were found to be 274.6 and 144.7 mg/g, respectively, at a HZSM5 content of 10 wt %, an adsorbent dosage of 1 g/L, and pH

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

Plant growth regulation by seed coating with films of alginate and auxin-intercalated layered double hydroxides

• Vander A. de Castro,
• Valber G. O. Duarte,
• Danúbia A. C. Nobre,
• Geraldo H. Silva,
• Vera R. L. Constantino,
• Frederico G. Pinto,
• Willian R. Macedo and
• Jairo Tronto

Beilstein J. Nanotechnol. 2020, 11, 1082–1091, doi:10.3762/bjnano.11.93

• growth. This work describes (i) the synthesis and characterization of a zinc–aluminium LDH intercalated with NAA (ZnAl-NAA-LDH); (ii) the preparation a hybrid films for bean seed coating (Phaseolus vulgaris L.) containing a mixture of sodium alginate and ZnAl-NAA-LDH; (iii) bioassays with the coated

• All reagents used in this work were of analytical purity: Zn(NO3)2·6H2O (96.0%) and Al(NO3)3·9H2O (98.5%) were provided by Dinâmica; 1-naphthaleneacetic acid (C12H10O2, 97.0%), acetonitrile (C2H3N, 99.8%), sodium alginate (NaC6H7O6, >99.0%) and calcium nitrate (Ca(NO3)2, (99.0%) were supplied by Vetec

• sodium alginate in water for 2 h. The bean seeds were immersed in the gel and subsequently in a 5.0% solution of Ca(NO3)2 for 10 s to initiate the formation of films on the seeds surface. To homogenize the films, before being used in the bioassays, the seeds were dried in a drying oven at 25 °C for 2 h

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• cancer cells was achieved through folate-targeted sodium alginate/chitosan capsules. The lipid coating on the PAH/PSS microcapsule surface significantly reduced the permeability of the capsule walls [110]. Alternatively, carbohydrate functionalization has been widely used in hepatic drug delivery systems

Biological and biomimetic materials and surfaces

• Stanislav Gorb and
• Thomas Speck

Beilstein J. Nanotechnol. 2017, 8, 403–407, doi:10.3762/bjnano.8.42

• articles of this Thematic Series, Egorov et al. proposed a relatively simple protocol for 3D printing of complex-shaped biocompatible structures based on sodium alginate and calcium phosphate for bone tissue engineering [24]. The analysis of 3D printed structures shows that they possess large

3D printing of mineral–polymer bone substitutes based on sodium alginate and calcium phosphate

• Aleksey A. Egorov,
• Alexander Yu. Fedotov,
• Anton V. Mironov,
• Vladimir S. Komlev,
• Vladimir K. Popov and
• Yury V. Zobkov

Beilstein J. Nanotechnol. 2016, 7, 1794–1799, doi:10.3762/bjnano.7.172

• Research Centre "Crystallography and Photonics", Russian Academy of Sciences, 2 Pionerskaya St., 142092 Troitsk, Moscow, Russia 10.3762/bjnano.7.172 Abstract We demonstrate a relatively simple route for three-dimensional (3D) printing of complex-shaped biocompatible structures based on sodium alginate and

• Discussion 3D printing is a powerful tool for the production of custom-designed and complex bone substitutes [2][3]. In our work, the fabrication of 3D composite structures was performed using a binary system based on aqueous solutions of sodium alginate containing PO43− groups. A calcium chloride aqueous

• binary system based on aqueous solutions of sodium alginate. The polymer slurry of sodium alginate (CAS number 9005-38-3) with concentrations of 0.25, 1.0 and 2.0 wt % was prepared in distilled water in presence of glutamic acid (C5H9NO4) (CAS number 56-86-0) with concentrations of 0.25, 1.0 and 2.0 wt

Preparation of alginate–chitosan–cyclodextrin micro- and nanoparticles loaded with anti-tuberculosis compounds

• Albert Ivancic,
• Fliur Macaev,
• Fatma Aksakal,
• Veaceslav Boldescu,
• Serghei Pogrebnoi and
• Gheorghe Duca

Beilstein J. Nanotechnol. 2016, 7, 1208–1218, doi:10.3762/bjnano.7.112

• ; quaternary system; sodium alginate; Introduction Tuberculosis, together with HIV infection, is a leading cause of death with 1.5 million deaths in 2014 worldwide [1]. The biggest challenges regarding a successful treatment of tuberculosis infections are the necessary high dosages and various side effects of

• active site of InhA and isoconazole in order to discuss these interactions with the frontier molecular orbital (FMO) analysis of the electron density distribution. The main carriers used in our particles are β-cyclodextrin, sodium alginate, and chitosan. β-Cyclodextrin (β-CD), a cyclic oligosaccharide

• consisting of seven D-glucopyranonsyl units. Because of its size and specific structure it can form inclusion complexes with preferentially lipophilic low-molecular-weight compounds. Sodium alginate is a salt of alginic acid, a naturally occurring linear polysaccharide consisting of 1,4-linked β-D

Self-assembled anchor layers/polysaccharide coatings on titanium surfaces: a study of functionalization and stability

• Ognen Pop-Georgievski,
• Dana Kubies,
• Josef Zemek,
• Neda Neykova,
• Roman Demianchuk,
• Eliška Mázl Chánová,
• Miroslav Šlouf,
• Milan Houska and
• František Rypáček

Beilstein J. Nanotechnol. 2015, 6, 617–631, doi:10.3762/bjnano.6.63

• Materials Dopamine hydrochloride (98.5%) was purchased from Sigma and 3-triethoxysilylpropan-1-amine from Aldrich. 3-(Ethyliminomethyleneamino)-N,N-dimethylpropan-1-amine (EDC), 1-hydroxy-2,5-pyrrolidinedione (NHS) and 2-(morpholin-4-yl)ethanesulfonic acid (MES) were obtained from Fluka. Sodium alginate