Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

• .15.131 Abstract Endosomal entrapment significantly limits the efficacy of drug delivery systems. This study investigates sodium oleate-modified liposomes (SO-Lipo) as an innovative strategy to enhance endosomal escape and improve cytosolic delivery in 4T1 triple-negative breast cancer cells. We aimed to

• elucidate the mechanistic role of sodium oleate in promoting endosomal escape and compared the performance of SO-Lipo with unmodified liposomes (Unmodified-Lipo) and Aurein 1.2-modified liposomes (AUR-Lipo). Liposomes were prepared using the thin-film hydration method, resulting in Unmodified-Lipo, SO-Lipo

• measuring the colocalization of labeled liposomes with lysosomal markers, quantified using Pearson’s correlation coefficient. Lipid mixing assays assessed the potential fusogenic effect, and molecular dynamics (MD) simulations explored the interactions of protonated sodium oleate (SO) with the endosomal

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

• Cynthia Kembuan,
• Helena Oliveira and
• Christina Graf

Beilstein J. Nanotechnol. 2021, 12, 35–48, doi:10.3762/bjnano.12.3

• -aminopropyltrimethoxysilane (APS, 99%), rhodamine B isothiocyanate (RBITC, ≥95%), polyoxyethylene-(5)-nonylphenyl ether (Igepal® CO-520), ammonium fluoride (NH4F, 99.8%), 1-octadecene (tech. 95%), sodium oleate (82%), tetraethyl orthosilicate (TEOS, 98%), as well as erbium, yttrium, and ytterbium standards for ICP-OES

Uniform Fe₃O₄/Gd₂O₃-DHCA nanocubes for dual-mode magnetic resonance imaging

• Miao Qin,
• Yueyou Peng,
• Mengjie Xu,
• Hui Yan,
• Yizhu Cheng,
• Xiumei Zhang,
• Di Huang,
• Weiyi Chen and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2020, 11, 1000–1009, doi:10.3762/bjnano.11.84

• (C2H6O), sodium hydroxide (NaOH) and tetrahydrofuran (C4H8O, THF) were purchased from Tianjin Kaitong Chemical Reagent Co, Ltd. Oleylamine (C18H37N), 1-octadecene (C18H36), sodium oleate (C18H33NaO2), 3,4-dihydroxyhydrocinnamic acid (C9H10O4, DHCA), gadolinium acetate hydrate (Gd(CH3CO2)3·xH2O) and

• methods used for synthesizing metal oleate precursors were described in detail in a previous study [34]. 10 mmol sodium oleate was dissolved in a solution containing 60 mL ultrapure water and 20 mL ethanol, 5.0 mmol iron(III) chloride and 1.0 mmol gadolinium chloride hexahydrate were dissolved in 20 mL

• significance was assessed using the Student’s t-test and the values were considered significant at P < 0.05. “*”, “**”, and “***” represent P < 0.05, P < 0.01, and P < 0.001, respectively. Schematic illustration of FGDA nanocube synthesis. Briefly, a mixture containing sodium oleate, water, ethanol and metal

Coating of upconversion nanoparticles with silica nanoshells of 5–250 nm thickness

• Cynthia Kembuan,
• Maysoon Saleh,
• Bastian Rühle,
• Ute Resch-Genger and
• Christina Graf

Beilstein J. Nanotechnol. 2019, 10, 2410–2421, doi:10.3762/bjnano.10.231

• -octadecene (tech. 95%), sodium oleate (82%), tetraethyl orthosilicate (TEOS, 98%) as well as yttrium-, ytterbium- and erbium standards for inductively coupled plasma optical emission spectroscopy (ICP-OES) measurements (TraceCERT®, c = 1000 mg/mL) were purchased from Sigma Aldrich. All chemicals were used

The role of ligands in coinage-metal nanoparticles for electronics

• Ioannis Kanelidis and
• Tobias Kraus

Beilstein J. Nanotechnol. 2017, 8, 2625–2639, doi:10.3762/bjnano.8.263

• , which grew into micrometer-long uniform silver nanowires [20][69]. Ligands also affect the geometry of gold and copper nanostructures that form in liquid. Cetyltrimethylammonium bromide and sodium oleate in an aqueous reaction mixture with hydrogen tetrachloroaurate trihydrate as precursor led to the

• formation of gold nanorods with controllable aspect ratios. In the presence of CTAB alone, rods with a broad size distribution formed (see above [65]) in a mixture with other shapes. An improved protocol with a binary surfactant mixture of CTAB and sodium oleate led to gold nanorods with a narrower size

• distribution (full width at half maximum between 110 and 170 nm) and shape impurities of less than 0.5% of the total number of nanoparticles. This uniformity was attributed to the coexistence of CTAB and sodium oleate; the oleate appears to mediate the binding between CTAB and certain facets of the growing

Comparison of four methods for the biofunctionalization of gold nanorods by the introduction of sulfhydryl groups to antibodies

• Xuefeng Wang,
• Zhong Mei,
• Yanyan Wang and
• Liang Tang

Beilstein J. Nanotechnol. 2017, 8, 372–380, doi:10.3762/bjnano.8.39

• trihydrate (HAuCl4·3H2O; 99%), cetyltrimethylammonium bromide (CTAB), sodium borohydride (NaBH4; 99%), silver nitrate (AgNO3; 99%), L-ascorbic acid (AA), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimidehydrochloride (EDC), sodium oleate (NaOL; >97%), hydrochloric acid (HCl, 37%), (3-mercaptopropyl

From iron coordination compounds to metal oxide nanoparticles

• Mihail Iacob,
• Carmen Racles,
• Codrin Tugui,
• George Stiubianu,
• Adrian Bele,
• Liviu Sacarescu,
• Daniel Timpu and
• Maria Cazacu

Beilstein J. Nanotechnol. 2016, 7, 2074–2087, doi:10.3762/bjnano.7.198

• method Samples NPS1–NPS3 were prepared by a solvothermal method (Supporting Information File 1, Figure S10) from a mixture of μ3-oxo trinuclear iron acetate ([Fe3O(CH3COO)6(H2O)3]NO3·4H2O), FeAc2, used as the source of iron, sodium oleate (NaOI) and/or DA used as stabilizing agents, and TCAA as solvent