Beilstein J. Nanotechnol.2025,16, 229–251, doi:10.3762/bjnano.16.18
, temozolomide (TMZ), a drug used for the treatment of anaplastic astrocytoma and glioblastoma multiforme (GBM), was incorporated into multiwalled carbon nanotubes (MWCNTs) and a MWCNTs–graphene (MWCNTs-G) hybrid compound, covalently functionalized with polyethylene glycol (PEG) 6000 and folic acid (FA), with an
nanostructures; cytotoxicity; glioblastoma multiforme; radiosensitizing properties; temozolomide; Introduction
Carbon-based nanostructures (CNs) such as graphene and its derivatives, carbon nanotubes (CNTs), fullerenes, carbon quantum dots, carbon nanohorns and nanodiamonds (NDs), and their hybrids are becoming
, and photodynamic therapy.
Cytotoxic drugs acting by preventing DNA replication and apoptosis via methylation of guanine-rich areas in DNA and by cross-linking guanine and cytosine in DNA strains are a standard in chemotherapy. Among them, the prodrug temozolomide (TMZ) with its active metabolite 5-(3
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Figure 1:
SEM images of (a) MWCNTs-PEG6000, (b) MWCNTs-PEG6000-FA, (c) MWCNTs-PEG6000-TMZ, (d) MWCNTs-PEG6000...
Beilstein J. Nanotechnol.2020,11, 866–883, doi:10.3762/bjnano.11.72
another study, arginine–glycine–aspartic acid peptide (RGD)-modified NLCs were used for the delivery of temozolomide (TMZ) and their efficacy was tested on a glioblastoma multiforme mouse model. The RGD-TMZ/NLCs displayed high antitumor efficacy in vivo, with an inhibition of the tumor four times higher
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Figure 1:
Blood–brain barrier anatomy. Inspired by [5].