Beilstein J. Nanotechnol.2026,17, 176–185, doi:10.3762/bjnano.17.11
tests are the black box (see Figure 2). They provide no mechanistic insights to explain the observed impacts. However, extending traditional animal tests with approaches such as toxicogenomics analyses increases the transparency of the box (system). Incorporating alternative test methods (also called
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Figure 1:
Nanomaterial life cycle underpinned by AI.
Beilstein J. Nanotechnol.2015,6, 2438–2448, doi:10.3762/bjnano.6.252
; toxicogenomics; Introduction
Metadata analysis that leverages genomics data has become increasingly popular as more experiments populate publicly available data repositories such as the Gene Expression Omnibus (GEO; http://www.ncbi.nlm.nih.gov/geo/) and European Bioinformatics Institute (EBI; https
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Figure 1:
Heatmap of the gene symbols obtained from the bicluster data analysis. The distance metric used for...