Preparation of new alkyne-modified ansamitocins by mutasynthesis

Scholarly Works

• Skrzypczak, N.; Buczkowski, A.; Bohusz, W.; Nowak, E.; Tokarska, K.; Leśniewska, A.; Alzebari, A. M.; Ruszkowski, P.; Gdaniec, M.; Bartl, F.; Przybylski, P. Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicity. European journal of medicinal chemistry 2023, 256, 115450. doi:10.1016/j.ejmech.2023.115450
• Skrzypczak, N.; Przybylski, P. Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners. Natural product reports 2022, 39, 1678–1704. doi:10.1039/d2np00004k
• Bergueiro, J.; Glitscher, E. A.; Calderón, M. A hybrid thermoresponsive plasmonic nanogel designed for NIR-mediated chemotherapy. Biomaterials advances 2022, 137, 212842. doi:10.1016/j.bioadv.2022.212842
• Sundar, K.; Prabu, T. R. Microbial metabolites in nutrition and healthcare. Volatiles and Metabolites of Microbes; Elsevier, 2021; pp 235–256. doi:10.1016/b978-0-12-824523-1.00012-2
• Skrzypczak, N.; Pyta, K.; Ruszkowski, P.; Mikołajczak, P.; Kucinska, M.; Murias, M.; Gdaniec, M.; Bartl, F.; Przybylski, P. Anticancer activity and toxicity of new quaternary ammonium geldanamycin derivative salts and their mixtures with potentiators. Journal of enzyme inhibition and medicinal chemistry 2021, 36, 1898–1904. doi:10.1080/14756366.2021.1960829
• Wesemann, F.; Heutling, A.; Wienecke, P.; Kirschning, A. First Ring-Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant. Chembiochem : a European journal of chemical biology 2020, 21, 2927–2930. doi:10.1002/cbic.202000336
• Padilla-Salinas, R.; Sun, L.; Anderson, R.; Yang, X.; Zhang, S.; Chen, Z. J.; Yin, H. Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors. The Journal of organic chemistry 2020, 85, 1579–1600. doi:10.1021/acs.joc.9b02666
• Porterfield, W. B.; Zhang, W. Mutasynthesis for Natural Product Bioengineering. Comprehensive Natural Products III; Elsevier, 2020; pp 336–351. doi:10.1016/b978-0-12-409547-2.14633-5
• Klahn, P.; Fetz, V.; Ritter, A.; Collisi, W.; Hinkelmann, B.; Arnold, T.; Tegge, W.; Rox, K.; Hüttel, S.; Mohr, K. I.; Wink, J.; Stadler, M.; Wissing, J.; Jänsch, L.; Brönstrup, M. The nuclear export inhibitor aminoratjadone is a potent effector in extracellular-targeted drug conjugates. Chemical science 2019, 10, 5197–5210. doi:10.1039/c8sc05542d
• Dehimat, Z. I.; Yaşar, S.; Tebbani, D.; Özdemir, İ. Sonogashira cross-coupling reaction catalyzed by N-heterocyclic carbene-Pd(II)-PPh3 complexes under copper free and aerobic conditions. Inorganica Chimica Acta 2018, 469, 325–334. doi:10.1016/j.ica.2017.09.048
• de Cassia Pessotti, R.; Caraballo-Rodríguez, A. M.; Ortega-Domínguez, H. E.; Pupo, M. T.; Newman, D. J.; Cragg, G. M.; Grothaus, P. G. Terrestrial Microbial Natural Products Discovery Guided by Symbiotic Interactions and Revealed by Advanced Analytical Methods. Chemical Biology of Natural Products; CRC Press, 2017; pp 161–188. doi:10.1201/9781315117089-5
• Devkule, S.; Chavan, S. Copper(I) complexes of N -(2-quinolynylmethylene)-1 H -benzimidazole and triphenylphosphine: Synthesis, characterization, luminescence and catalytic properties. Inorganica Chimica Acta 2017, 466, 122–129. doi:10.1016/j.ica.2017.05.076
• Classen, T.; Pietruszka, J. Complex molecules, clever solutions – Enzymatic approaches towards natural product and active agent syntheses. Bioorganic & medicinal chemistry 2017, 26, 1285–1303. doi:10.1016/j.bmc.2017.06.045
• Lin, J.; Zhong, J.-J. Proteomic studies on anti-tumor agent ansamitocin P-3 producer Actinosynnema pretiosum in response to ammonium and isobutanol. Bioprocess and biosystems engineering 2017, 40, 1133–1139. doi:10.1007/s00449-017-1763-5
• Dewan, A.; Sarmah, M.; Bora, U.; Thakur, A. J. A green protocol for ligand, copper and base free Sonogashira cross-coupling reaction. Tetrahedron Letters 2016, 57, 3760–3763. doi:10.1016/j.tetlet.2016.07.021
• Pošta, M.; Soós, V.; Beier, P. Design of photoaffinity labeling probes derived from 3,4,5-trimethylfuran-2(5H)-one for mode of action elucidation. Tetrahedron 2016, 72, 3809–3817. doi:10.1016/j.tet.2016.03.096
• Boecker, S.; Zobel, S.; Meyer, V.; Süssmuth, R. D. Rational biosynthetic approaches for the production of new-to-nature compounds in fungi. Fungal genetics and biology : FG & B 2016, 89, 89–101. doi:10.1016/j.fgb.2016.02.003
• Lehmann, J.; Wright, M. H.; Sieber, S. A. Making a Long Journey Short: Alkyne Functionalization of Natural Product Scaffolds. Chemistry (Weinheim an der Bergstrasse, Germany) 2016, 22, 4666–4678. doi:10.1002/chem.201504419
• Bułyszko, I.; Dräger, G.; Klenge, A.; Kirschning, A. Evaluation of the Synthetic Potential of an AHBA Knockout Mutant of the Rifamycin Producer Amycolatopsis mediterranei. Chemistry (Weinheim an der Bergstrasse, Germany) 2015, 21, 19231–19242. doi:10.1002/chem.201503548
• Song, Y. N.; Jiao, R. H.; Zhang, W. J.; Zhao, G. Y.; Dou, H.; Jiang, R.; Zhang, A. H.; Hou, Y. Y.; Bi, S. F.; Ge, H. M.; Tan, R.-X. New ansamycin derivatives generated by simultaneous mutasynthesis. Organic letters 2015, 17, 556–559. doi:10.1021/ol5035639

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