Formulation development, stability and anticancer efficacy of core-shell cyclodextrin nanocapsules for oral chemotherapy with camptothecin

Hale Ünal, Naile Öztürk and Erem Bilensoy
Beilstein J. Org. Chem. 2015, 11, 204–212. https://doi.org/10.3762/bjoc.11.22

Supporting Information

The Supporting Information includes pre-formulation studies of CD nanocapsules, physicochemical characterization of CPT-loaded CD nanocapsules, determination of CPT loading, in vitro CPT release studies, CPT stability in simulated GI fluids and cytotoxicity, anticancer efficacy and permeability assay of CD nanocapsules.

Supporting Information File 1: Experimental data.
Format: PDF Size: 321.4 KB Download

Cite the Following Article

Formulation development, stability and anticancer efficacy of core-shell cyclodextrin nanocapsules for oral chemotherapy with camptothecin
Hale Ünal, Naile Öztürk and Erem Bilensoy
Beilstein J. Org. Chem. 2015, 11, 204–212. https://doi.org/10.3762/bjoc.11.22

How to Cite

Ünal, H.; Öztürk, N.; Bilensoy, E. Beilstein J. Org. Chem. 2015, 11, 204–212. doi:10.3762/bjoc.11.22

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Srag El-Din, A. S.; Yehia, A.; Hamza, E.; A-Elgadir, T. M. E.; Abd El-Fattah, E. E. Selenium nanoparticle ameliorates LPS-induced acute lung injury in rats through inhibition of ferroptosis, inflammation, and HSPs. Journal of Drug Delivery Science and Technology 2024, 95, 105626. doi:10.1016/j.jddst.2024.105626
  • Sarabia-Vallejo, Á.; Caja, M. D. M.; Olives, A. I.; Martín, M. A.; Menéndez, J. C. Cyclodextrin Inclusion Complexes for Improved Drug Bioavailability and Activity: Synthetic and Analytical Aspects. Pharmaceutics 2023, 15, 2345. doi:10.3390/pharmaceutics15092345
  • Dehariya, D.; Eswar, K.; Tarafdar, A.; Balusamy, S.; Rengan, A. K. Recent advances of nanobubble-based systems in cancer therapeutics: A Review. Biomedical Engineering Advances 2023, 5, 100080. doi:10.1016/j.bea.2023.100080
  • Yang, J.; Jia, L.; He, Z.; Wang, Y. Recent advances in SN-38 drug delivery system. International journal of pharmaceutics 2023, 637, 122886. doi:10.1016/j.ijpharm.2023.122886
  • Ünal, S.; Varan, G.; Benito, J. M.; Aktaş, Y.; Bilensoy, E. Insight into oral amphiphilic cyclodextrin nanoparticles for colorectal cancer: comprehensive mathematical model of drug release kinetic studies and antitumoral efficacy in 3D spheroid colon tumors. Beilstein journal of organic chemistry 2023, 19, 139–157. doi:10.3762/bjoc.19.14
  • Daşkın, D.; Erdoğar, N.; İskit, A. B.; Bilensoy, E. Oral docetaxel delivery with cationic polymeric core-shell nanocapsules: In vitro and in vivo evaluation. Journal of Drug Delivery Science and Technology 2023, 80, 104163. doi:10.1016/j.jddst.2023.104163
  • Çetin, K.; Şarkaya, K.; Denizli, A. Clinical applications and future clinical trials of the drug delivery system. Nanotechnology for Drug Delivery and Pharmaceuticals; Elsevier, 2023; pp 259–294. doi:10.1016/b978-0-323-95325-2.00020-1
  • Sachdeva, A.; Dhawan, D.; Jain, G. K.; Yerer, M. B.; Collignon, T. E.; Tewari, D.; Bishayee, A. Novel Strategies for the Bioavailability Augmentation and Efficacy Improvement of Natural Products in Oral Cancer. Cancers 2022, 15, 268. doi:10.3390/cancers15010268
  • Ünal, S.; Doğan, O.; Aktaş, Y. Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics. Beilstein journal of nanotechnology 2022, 13, 1393–1407. doi:10.3762/bjnano.13.115
  • Rao, Y.; Li, R.; Liu, S.; Meng, L.; Wu, Q.; Yuan, Q.; Liang, H.; Qin, M. Enhanced bioavailability and biosafety of cannabidiol nanomicelles for effective anti-inflammatory therapy. Particuology 2022, 69, 1–9. doi:10.1016/j.partic.2021.11.010
  • Narayanan, G.; Shen, J.; Matai, I.; Sachdev, A.; Boy, R.; Tonelli, A. E. Cyclodextrin-based nanostructures. Progress in Materials Science 2022, 124, 100869. doi:10.1016/j.pmatsci.2021.100869
  • Das, S. S.; Kar, S.; Singh, S.; Verma, P. R. P.; Hussain, A.; Beg, S. Chitosan-based systems for oral drug delivery applications. Chitosan in Drug Delivery; Elsevier, 2022; pp 23–53. doi:10.1016/b978-0-12-819336-5.00009-1
  • Pandya, M.; Chatterjee, B.; Ganti, S. Self-emulsifying Drug Delivery System for Oral Anticancer Therapy: Constraints and Recent Development. Current pharmaceutical design 2022, 28, 2538–2553. doi:10.2174/03666220606143443
  • Daşkın, D.; Erdoğar, N.; İskit, A. B.; Bilensoy, E. Oral Docetaxel Delivery with Cationic Polymeric Core-Shell Nanocapsules For Gastrointestinal Cancers: In Vitro and in Vivo Evaluation. SSRN Electronic Journal 2022. doi:10.2139/ssrn.4177749
  • Ünal, S.; Öztürk, S. C.; Bilgiç, E.; Yanik, H.; Korkusuz, P.; Aktaş, Y.; Benito, J. M.; Esendagli, G.; Bilensoy, E. Therapeutic efficacy and gastrointestinal biodistribution of polycationic nanoparticles for oral camptothecin delivery in early and late-stage colorectal tumor-bearing animal model. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2021, 169, 168–177. doi:10.1016/j.ejpb.2021.10.010
  • González-Ruiz, V.; Cores, Á.; Martín-Cámara, O.; Orellana, K.; Cervera-Carrascón, V.; Michalska, P.; Olives, A. I.; León, R.; Martín, M. A.; Menéndez, J. C. Enhanced Stability and Bioactivity of Natural Anticancer Topoisomerase I Inhibitors through Cyclodextrin Complexation. Pharmaceutics 2021, 13, 1609. doi:10.3390/pharmaceutics13101609
  • Su, C.; Ren, X.; Nie, F.; Li, T.; Lv, W.; Li, H.; Zhang, Y. Current advances in ultrasound-combined nanobubbles for cancer-targeted therapy: a review of the current status and future perspectives. RSC advances 2021, 11, 12915–12928. doi:10.1039/d0ra08727k
  • Varan, G.; Varan, C.; Öztürk, S. C.; Benito, J. M.; Esendagli, G.; Bilensoy, E. Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo. Nanomaterials (Basel, Switzerland) 2021, 11, 515. doi:10.3390/nano11020515
  • Erdoğar, N.; Akkın, S.; Nielsen, T. T.; Özçelebi, E.; Erdogdu, B.; Nemutlu, E.; Iskit, A. B.; Bilensoy, E. Development of oral aprepitant-loaded chitosan–polyethylene glycol-coated cyclodextrin nanocapsules: formulation, characterization, and pharmacokinetic evaluation. Journal of Pharmaceutical Investigation 2021, 51, 297–310. doi:10.1007/s40005-020-00511-x
  • Pankaj. Cyclodextrin Modified Block Polymer for Oral Chemotherapy. Journal of Pharmaceutical Research International 2021, 21–29. doi:10.9734/jpri/2020/v32i3831009
Other Beilstein-Institut Open Science Activities