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Cite the Following Article
Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists
Constantinos G. Neochoritis, Maryam Kazemi Miraki, Eman M. M. Abdelraheem, Ewa Surmiak, Tryfon Zarganes-Tzitzikas, Beata Łabuzek, Tad A. Holak and Alexander Dömling
Beilstein J. Org. Chem. 2019, 15, 513–520.
https://doi.org/10.3762/bjoc.15.45
How to Cite
Neochoritis, C. G.; Kazemi Miraki, M.; Abdelraheem, E. M. M.; Surmiak, E.; Zarganes-Tzitzikas, T.; Łabuzek, B.; Holak, T. A.; Dömling, A. Beilstein J. Org. Chem. 2019, 15, 513–520. doi:10.3762/bjoc.15.45
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Scholarly Works
- Kazemi, Z.; Rudbari, H. A.; Moini, N.; Momenbeik, F.; Carnamucio, F.; Micale, N. Indole-Containing Metal Complexes and Their Medicinal Applications. Molecules (Basel, Switzerland) 2024, 29, 484. doi:10.3390/molecules29020484
- Dewis, L. I.; Rudrakshula, M.; Williams, C.; Chiarparin, E.; Myers, E. L.; Butts, C. P.; Aggarwal, V. K. Conformationally Controlled sp3 -Hydrocarbon-Based α-Helix Mimetics. Angewandte Chemie (International ed. in English) 2023, 62, e202301209. doi:10.1002/anie.202301209
- Dewis, L. I.; Rudrakshula, M.; Williams, C.; Chiarparin, E.; Myers, E. L.; Butts, C. P.; Aggarwal, V. K. Conformationally Controlled sp3‐Hydrocarbon‐Based α‐Helix Mimetics. Angewandte Chemie 2023, 135. doi:10.1002/ange.202301209
- Fotopoulou, E.; Fragkiadakis, M.; Neochoritis, C. G. Macrocyclization tactics: The MCR approach. Tetrahedron Letters 2023, 120, 154453. doi:10.1016/j.tetlet.2023.154453
- Abdelraheem, E.; Lubberink, M.; Wang, W.; Li, J.; Reyes Romero, A.; van der Straat, R.; Du, X.; Groves, M.; Dömling, A. Multicomponent Macrocyclic IL-17a Modifier. ACS medicinal chemistry letters 2022, 13, 1468–1471. doi:10.1021/acsmedchemlett.2c00257
- Mohammadi Ziarani, G.; Hasani, S.; Mohajer, F.; Varma, R. S.; Rafiee, F. The Molecular Diversity of 1H-Indole-3-Carbaldehyde Derivatives and Their Role in Multicomponent Reactions. Topics in current chemistry (Cham) 2022, 380, 24. doi:10.1007/s41061-022-00379-5
- González-Muñiz, R.; Bonache, M. A.; de Vega, M. J. P. Modulating Protein–Protein Interactions by Cyclic and Macrocyclic Peptides. Prominent Strategies and Examples. Molecules (Basel, Switzerland) 2021, 26, 445. doi:10.3390/molecules26020445
- Romero, A. R.; Ruiz-Moreno, A. J.; Groves, M.; Velasco-Velázquez, M. A.; Dömling, A. Benchmark of Generic Shapes for Macrocycles. Journal of chemical information and modeling 2020, 60, 6298–6313. doi:10.1021/acs.jcim.0c01038
- Tripolitsiotis, N. P.; Thomaidi, M.; Neochoritis, C. G. The Ugi Three-Component Reaction; a Valuable Tool in Modern Organic Synthesis. European Journal of Organic Chemistry 2020, 2020, 6525–6554. doi:10.1002/ejoc.202001157
- Beloglazkina, A. A.; Zyk, N. V.; Majouga, A. G.; Beloglazkina, E. K. Recent Small-Molecule Inhibitors of the p53-MDM2 Protein-Protein Interaction. Molecules (Basel, Switzerland) 2020, 25, 1211. doi:10.3390/molecules25051211
Patents
- DURDAĞI SERDAR; AVŞAR TIMUÇIN; ORHAN MÜGE DIDEM; PAKSOY MAIDE NUR; AYDIN GÜLŞAH; YURTSEVER MINE. DRG-MDM2-4 FOR USE AS A NOVEL MOUSE DOUBLE MINUTE 2 (MDM2) INHIBITOR. WO 2021167573 A1, Aug 26, 2021.
- ARONICA PIETRO; BROWN CHRISTOPER; FERRER FERNANDO; JOHANNES CHARLES; KANNAN SRINIVASARAGHAVAN; LANE DAVID; PARTRIDGE ANTHONY; TAN YAW SING; VERMA CHANDRA; YUEN TSZ YING. P53 ACTIVATOR PEPTIDOMIMETIC MACROCYCLES. WO 2020257153 A1, Dec 24, 2020.
- ARONICA PIETRO; BROWN CHRISTOPER; FERRER FERNANDO; JOHANNES CHARLES; KANNAN SRINIVASARAGHAVAN; LANE DAVID; PARTRIDGE ANTHONY; TAN YAW SING; VERMA CHANDRA; YUEN TSZ YING. P53 ACTIVATOR PEPTIDOMIMETIC MACROCYCLES. WO 2020257133 A1, Dec 24, 2020.
