Multicomponent reactions III
Heinrich-Heine-Universität Düsseldorf
Multicomponent reactions (MCR) are highly efficient one-pot processes, where three or more compounds are selectively transformed into a product that contains substantial amounts of the starting materials atoms. These sequences proceed as a reactivity-based concept by the perpetual generation of reactive functionalities, void of any isolation intermediate products. In their nature MCR are particularly interesting for exploring huge structural and functional spaces, a domain of the development of active pharmaceutical ingredients, and increasingly more, of functional organic materials.
This thematic issue on multicomponent reactions continues the previously released two series presenting again a snap shot view on a highly dynamic field.
Multicomponent reactions III
- Thomas J. J. Müller
Beilstein J. Org. Chem. 2019, 15, 1974–1975, doi:10.3762/bjoc.15.192
Mn-mediated sequential three-component domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction towards annulated imidazo[1,2-a]pyridines
- Olga A. Storozhenko,
- Alexey A. Festa,
- Delphine R. Bella Ndoutoume,
- Alexander V. Aksenov,
- Alexey V. Varlamov and
- Leonid G. Voskressensky
Beilstein J. Org. Chem. 2018, 14, 3078–3087, doi:10.3762/bjoc.14.287
Microwave-assisted synthesis of N,N-bis(phosphinoylmethyl)amines and N,N,N-tris(phosphinoylmethyl)amines bearing different substituents on the phosphorus atoms
- Erika Bálint,
- Anna Tripolszky,
- László Hegedűs and
- György Keglevich
Beilstein J. Org. Chem. 2019, 15, 469–473, doi:10.3762/bjoc.15.40
Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists
- Constantinos G. Neochoritis,
- Maryam Kazemi Miraki,
- Eman M. M. Abdelraheem,
- Ewa Surmiak,
- Tryfon Zarganes-Tzitzikas,
- Beata Łabuzek,
- Tad A. Holak and
- Alexander Dömling
Beilstein J. Org. Chem. 2019, 15, 513–520, doi:10.3762/bjoc.15.45
Selectivity in multiple multicomponent reactions: types and synthetic applications
- Ouldouz Ghashghaei,
- Francesca Seghetti and
- Rodolfo Lavilla
Beilstein J. Org. Chem. 2019, 15, 521–534, doi:10.3762/bjoc.15.46
Catalyst-free assembly of giant tris(heteroaryl)methanes: synthesis of novel pharmacophoric triads and model sterically crowded tris(heteroaryl/aryl)methyl cation salts
- Rodrigo Abonia,
- Luisa F. Gutiérrez,
- Braulio Insuasty,
- Jairo Quiroga,
- Kenneth K. Laali,
- Chunqing Zhao,
- Gabriela L. Borosky,
- Samantha M. Horwitz and
- Scott D. Bunge
Beilstein J. Org. Chem. 2019, 15, 642–654, doi:10.3762/bjoc.15.60
The LANCA three-component reaction to highly substituted β-ketoenamides – versatile intermediates for the synthesis of functionalized pyridine, pyrimidine, oxazole and quinoxaline derivatives
- Tilman Lechel,
- Roopender Kumar,
- Mrinal K. Bera,
- Reinhold Zimmer and
- Hans-Ulrich Reissig
Beilstein J. Org. Chem. 2019, 15, 655–678, doi:10.3762/bjoc.15.61
Synthesis of a novel category of pseudo-peptides using an Ugi three-component reaction of levulinic acid as bifunctional substrate, amines, and amino acid-based isocyanides
- Maryam Khalesi,
- Azim Ziyaei Halimehjani and
- Jürgen Martens
Beilstein J. Org. Chem. 2019, 15, 852–857, doi:10.3762/bjoc.15.82
Synthesis of (macro)heterocycles by consecutive/repetitive isocyanide-based multicomponent reactions
- Angélica de Fátima S. Barreto and
- Carlos Kleber Z. Andrade
Beilstein J. Org. Chem. 2019, 15, 906–930, doi:10.3762/bjoc.15.88
Novel (2-amino-4-arylimidazolyl)propanoic acids and pyrrolo[1,2-c]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds
- Victoria V. Lipson,
- Tetiana L. Pavlovska,
- Nataliya V. Svetlichnaya,
- Anna A. Poryvai,
- Nikolay Yu. Gorobets,
- Erik V. Van der Eycken,
- Irina S. Konovalova,
- Svetlana V. Shiskina,
- Alexander V. Borisov,
- Vladimir I. Musatov and
- Alexander V. Mazepa
Beilstein J. Org. Chem. 2019, 15, 1032–1045, doi:10.3762/bjoc.15.101
A three-component, Zn(OTf)2-mediated entry into trisubstituted 2-aminoimidazoles
- Alexei Lukin,
- Anna Bakholdina,
- Anna Kryukova,
- Alexander Sapegin and
- Mikhail Krasavin
Beilstein J. Org. Chem. 2019, 15, 1061–1064, doi:10.3762/bjoc.15.103
Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams
- Edorta Martínez de Marigorta,
- Jesús M. de Los Santos,
- Ana M. Ochoa de Retana,
- Javier Vicario and
- Francisco Palacios
Beilstein J. Org. Chem. 2019, 15, 1065–1085, doi:10.3762/bjoc.15.104
Ugi reaction-derived prolyl peptide catalysts grafted on the renewable polymer polyfurfuryl alcohol for applications in heterogeneous enamine catalysis
- Alexander F. de la Torre,
- Gabriel S. Scatena,
- Oscar Valdés,
- Daniel G. Rivera and
- Márcio W. Paixão
Beilstein J. Org. Chem. 2019, 15, 1210–1216, doi:10.3762/bjoc.15.118
Steroid diversification by multicomponent reactions
- Leslie Reguera,
- Cecilia I. Attorresi,
- Javier A. Ramírez and
- Daniel G. Rivera
Beilstein J. Org. Chem. 2019, 15, 1236–1256, doi:10.3762/bjoc.15.121
Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction
- Maryna V. Murlykina,
- Oleksandr V. Kolomiets,
- Maryna M. Kornet,
- Yana I. Sakhno,
- Sergey M. Desenko,
- Victoriya V. Dyakonenko,
- Svetlana V. Shishkina,
- Oleksandr A. Brazhko,
- Vladimir I. Musatov,
- Alexander V. Tsygankov,
- Erik V. Van der Eycken and
- Valentyn A. Chebanov
Beilstein J. Org. Chem. 2019, 15, 1281–1288, doi:10.3762/bjoc.15.126
One-pot activation–alkynylation–cyclization synthesis of 1,5-diacyl-5-hydroxypyrazolines in a consecutive three-component fashion
- Christina Görgen,
- Katharina Boden,
- Guido J. Reiss,
- Walter Frank and
- Thomas J. J. Müller
Beilstein J. Org. Chem. 2019, 15, 1360–1370, doi:10.3762/bjoc.15.136
Efficiency Effsyn of complex syntheses as multicomponent reactions, its algorithm and calculations based on concrete criteria
- Heiner Eckert
Beilstein J. Org. Chem. 2019, 15, 1425–1433, doi:10.3762/bjoc.15.142
A novel three-component reaction between isocyanides, alcohols or thiols and elemental sulfur: a mild, catalyst-free approach towards O-thiocarbamates and dithiocarbamates
- András György Németh,
- György Miklós Keserű and
- Péter Ábrányi-Balogh
Beilstein J. Org. Chem. 2019, 15, 1523–1533, doi:10.3762/bjoc.15.155
