Selectivity in multiple multicomponent reactions: types and synthetic applications

Ouldouz Ghashghaei, Francesca Seghetti and Rodolfo Lavilla
Beilstein J. Org. Chem. 2019, 15, 521–534. https://doi.org/10.3762/bjoc.15.46

Cite the Following Article

Selectivity in multiple multicomponent reactions: types and synthetic applications
Ouldouz Ghashghaei, Francesca Seghetti and Rodolfo Lavilla
Beilstein J. Org. Chem. 2019, 15, 521–534. https://doi.org/10.3762/bjoc.15.46

How to Cite

Ghashghaei, O.; Seghetti, F.; Lavilla, R. Beilstein J. Org. Chem. 2019, 15, 521–534. doi:10.3762/bjoc.15.46

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 218.5 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Motamed, N. K.; Larijani, K.; Pournamdari, E.; Saeidian, H.; Hargalani, F. Z. One pot multicomponent reaction of curcumin: Green synthesis of novel 1,4‐dihydropyridine‐2,3‐dicarboxylates. Journal of Heterocyclic Chemistry 2024. doi:10.1002/jhet.4857
  • Javahershenas, R.; Makarem, A.; Klika, K. D. Recent advances in microwave-assisted multicomponent synthesis of spiro heterocycles. RSC advances 2024, 14, 5547–5565. doi:10.1039/d4ra00056k
  • Pich, R.; Mallet‐Ladeira, S.; Lavedan, P.; Lahitte, J.; Remigy, J.; Pla, D.; Gómez, M. A Mechanistic Insight on CuI‐Catalyzed Synthesis of Oxazolidinones through a Four‐Component Reaction. Advanced Synthesis & Catalysis 2024, 366, 822–829. doi:10.1002/adsc.202301303
  • Mohamed, M. A.; Abouzied, A. S.; Reyad, A.; Sayed Abdelsalam Zaki, M. E.; Abdelgawad, F. E.; Al-Humaidi, J. Y.; Gomha, S. M. Novel terpyridines as Staphylococcus aureus gyrase inhibitors: efficient synthesis and antibacterial assessment via solvent-drop grinding. Future medicinal chemistry 2024, 16, 205–220. doi:10.4155/fmc-2023-0278
  • Javahershenas, R.; Makarem, A.; Mei, H.; Koley, M.; Soloshonok, V. A. Recent Advances in the Multicomponent Synthesis of Heterocycles Using 5-Aminotetrazole. Synthesis 2024. doi:10.1055/s-0042-1751526
  • Javahershenas, R.; Nikzat, S. Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles. Ultrasonics sonochemistry 2023, 102, 106741. doi:10.1016/j.ultsonch.2023.106741
  • Mei, L.; Shu, X.-R.; Liu, F.-L.; Li, J.-Z.; Zhang, J.-F.; Tang, K.; Wei, W.-T. Multicomponent hydrosulfonylation of alkynes for the synthesis of vinyl sulfones. Green Chemistry 2023, 25, 8820–8825. doi:10.1039/d3gc02284f
  • Sakthivel, K.; Gana, R. J.; Shoji, T.; Takenaga, N.; Dohi, T.; Singh, F. V. Recent progress in metal assisted multicomponent reactions in organic synthesis. Frontiers in chemistry 2023, 11, 1217744. doi:10.3389/fchem.2023.1217744
  • Javahershenas, R. Recent advances in the application of deep eutectic solvents for the synthesis of Spiro heterocyclic scaffolds via multicomponent reactions. Journal of Molecular Liquids 2023, 385, 122398. doi:10.1016/j.molliq.2023.122398
  • Yakkanti, C.; L, V. R.; Kerru, N.; Gorle, S.; Madhavaram, S.; Akula, R.; Bhaskaruni, S. V. H. S. One-Pot Multi-Component Synthesis of Polysubstituted Pyridines Using DBU-SiO 2 as a Robust Recyclable Catalyst. Polycyclic Aromatic Compounds 2023, 44, 2855–2862. doi:10.1080/10406638.2023.2225673
  • Nadal Rodríguez, P.; Ghashghaei, O.; Schoepf, A. M.; Benson, S.; Vendrell, M.; Lavilla, R. Charting the Chemical Reaction Space around a Multicomponent Combination: Controlled Access to a Diverse Set of Biologically Relevant Scaffolds. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 2023, 135, e202303889. doi:10.1002/ange.202303889
  • Nadal Rodríguez, P.; Ghashghaei, O.; Schoepf, A. M.; Benson, S.; Vendrell, M.; Lavilla, R. Charting the Chemical Reaction Space around a Multicomponent Combination: Controlled Access to a Diverse Set of Biologically Relevant Scaffolds. Angewandte Chemie (International ed. in English) 2023, 62, e202303889. doi:10.1002/anie.202303889
  • Javahershenas, R.; Nikzat, S. Recent advances in the multicomponent synthesis of heterocycles using tetronic acid. RSC advances 2023, 13, 16619–16629. doi:10.1039/d3ra02505e
  • Javahershenas, R. Application of phenacyl bromide analogs as a versatile organic intermediate for the synthesis of heterocyclic compounds via multicomponent reactions. Molecular diversity 2022, 27, 2399–2430. doi:10.1007/s11030-022-10544-z
  • Anaikutti, P.; Selvaraj, M.; Prabhakaran, J.; Pooventhiran, T.; Jeyakumar, T. C.; Thomas, R.; Makam, P. Indolyl-4H-chromenes: Multicomponent one-pot green synthesis, in vitro and in silico, anticancer and antioxidant studies. Journal of Molecular Structure 2022, 1266, 133464. doi:10.1016/j.molstruc.2022.133464
  • Hooshmand, S. E.; Yazdani, H.; Hulme, C. Six‐Component Reactions and Beyond: The Nuts and Bolts. European Journal of Organic Chemistry 2022, 2022. doi:10.1002/ejoc.202200569
  • Schlimpen, F.; Ast, T.; Bénéteau, V.; Pale, P.; Chassaing, S. From A3/KA2to AYA/KYA multicomponent coupling reactions with terminal ynamides as alkyne surrogates – a direct, green route to γ-amino-ynamides. Green Chemistry 2022, 24, 6467–6475. doi:10.1039/d2gc00966h
  • Ma, X.; Zhang, W. Recent developments in one-pot stepwise synthesis (OPSS) of small molecules. iScience 2022, 25, 105005. doi:10.1016/j.isci.2022.105005
  • Gobinath, P.; Packialakshmi, P.; Hatamleh, A. A.; Al-Dosary, M. A.; Al-Wasel, Y. A.; Balasubramani, R.; Surendrakumar, R.; Idhayadhulla, A. Calotropis gigantea Assisted Synthesis of Zinc Oxide Nanoparticle Catalysis: Synthesis of Novel 3-Amino Thymoquinone Connected 1,4-Dihyropyridine Derivatives and Their Cytotoxic Activity. Journal of Nanomaterials 2022, 2022, 1–10. doi:10.1155/2022/9697057
  • Molaei Yielzoleh, F.; Nikoofar, K. Metal-bio functionalized bismuthmagnetite [Fe3-x Bi x O4/SiO2@l-ArgEt3 +I-/Zn(ii)]: a novel bionanocomposite for the synthesis of 1,2,4,5-tetrahydro-2,4-dioxobenzo[b][1,4]diazepine malononitriles and malonamides at room temperature and under sonication. RSC advances 2022, 12, 10219–10236. doi:10.1039/d2ra00212d
Other Beilstein-Institut Open Science Activities