Regiodivergent synthesis of functionalized pyrimidines and imidazoles through phenacyl azides in deep eutectic solvents

Scholarly Works

• Cicco, L.; Perna, F. M.; Capriati, V.; Vitale, P. A Sustainable Synthetic Approach to Tacrine and Cholinesterase Inhibitors in Deep Eutectic Solvents under Aerobic Conditions. Molecules (Basel, Switzerland) 2024, 29, 1399. doi:10.3390/molecules29061399
• She, C.; Wang, A.; Liu, S.; Shu, W.; Yu, W. Preparation of Phenacyl Azides and Their Application Advances in Organic Synthesis. Chinese Journal of Organic Chemistry 2024, 44, 481. doi:10.6023/cjoc202307009
• Zlotin, S. G.; Egorova, K. S.; Ananikov, V. P.; Akulov, A. A.; Varaksin, M. V.; Chupakhin, O. N.; Charushin, V. N.; Bryliakov, K. P.; Averin, A. D.; Beletskaya, I. P.; Dolengovski, E. L.; Budnikova, Y. H.; Sinyashin, O. G.; Gafurov, Z. N.; Kantyukov, A. O.; Yakhvarov, D. G.; Aksenov, A. V.; Elinson, M. N.; Nenajdenko, V. G.; Chibiryaev, A. M.; Nesterov, N. S.; Kozlova, E. A.; Martyanov, O. N.; Balova, I. A.; Sorokoumov, V. N.; Guk, D. A.; Beloglazkina, E. K.; Lemenovskii, D. A.; Chukicheva, I. Y.; Frolova, L. L.; Izmest'ev, E. S.; Dvornikova, I. A.; Popov, A. V.; Kutchin, A. V.; Borisova, D. M.; Kalinina, A. A.; Muzafarov, A. M.; Kuchurov, I. V.; Maximov, A. L.; Zolotukhina, A. V. The green chemistry paradigm in modern organic synthesis. Russian Chemical Reviews 2023, 92, RCR5104. doi:10.59761/rcr5104
• Perrone, S.; Messa, F.; Troisi, L.; Salomone, A. N-, O- and S-Heterocycles Synthesis in Deep Eutectic Solvents. Molecules (Basel, Switzerland) 2023, 28, 3459. doi:10.3390/molecules28083459
• Newar, U. D.; Bora, K.; Borra, S.; Maurya, R. A. DBU mediated coupling of isatin with phenacyl azides: synthesis of 2-oxoindolin-3-ylbenzoates. New Journal of Chemistry 2023, 47, 2464–2473. doi:10.1039/d2nj05661e
• Cicco, L.; Roggio, M.; López-Aguilar, M.; Ramos-Martín, M.; Perna, F. M.; García-Álvarez, J.; Vitale, P.; Capriati, V. Selective Aerobic Oxidation of Alcohols in Low Melting Mixtures and Water and Use for Telescoped One-Pot Hybrid Reactions. ChemistryOpen 2022, 11, e202200160. doi:10.1002/open.202200160
• Dilauro, G.; Cicco, L.; Vitale, P.; Perna, F. M.; Capriati, V. Ligand‐Free Pd‐Catalyzed Reductive Mizoroki‐Heck Reaction Strategy for the One‐Pot Synthesis of Functionalized Oxygen Heterocycles in Deep Eutectic Solvents. European Journal of Organic Chemistry 2022, 26. doi:10.1002/ejoc.202200814
• Cicco, L.; Perna, F. M.; Falcicchio, A.; Altomare, A.; Messa, F.; Salomone, A.; Capriati, V.; Vitale, P. 1,3‐Dipolar Cycloaddition of Alkanone Enolates with Azides in Deep Eutectic Solvents for the Metal‐Free Regioselective Synthesis of Densely Functionalized 1,2,3‐Triazoles. European Journal of Organic Chemistry 2022, 2022. doi:10.1002/ejoc.202200843
• Borkotoky, L.; Maurya, R. A. Recent Advances onα‐Azidoketones and Esters in the Synthesis ofN‐Heterocycles. Asian Journal of Organic Chemistry 2022, 11. doi:10.1002/ajoc.202200254
• Quivelli, A. F.; Rossi, F. V.; Vitale, P.; García-Álvarez, J.; Perna, F. M.; Capriati, V. Sustainable and Scalable Two-Step Synthesis of Thenfadil and Some Analogs in Deep Eutectic Solvents: From Laboratory to Industry. ACS Sustainable Chemistry & Engineering 2022, 10, 4065–4072. doi:10.1021/acssuschemeng.2c00417
• Quivelli, A. F.; Marinò, M.; Vitale, P.; García-Álvarez, J.; Perna, F. M.; Capriati, V. Ligand-free Copper-Catalyzed Ullmann-type C-O Bond Formation in Non-innocent Deep Eutectic Solvents under Aerobic Conditions. ChemSusChem 2021, 15, e202102211. doi:10.1002/cssc.202102211
• Shaibuna, M.; Kuniyil, M. J. K.; Sreekumar, K. Deep eutectic solvent assisted synthesis of dihydropyrimidinones/thiones via Biginelli reaction: theoretical investigations on their electronic and global reactivity descriptors. New Journal of Chemistry 2021, 45, 20765–20775. doi:10.1039/d1nj03879f
• Vitale, P.; Cicco, L.; Perna, F. M.; Capriati, V. Introducing deep eutectic solvents in enolate chemistry: synthesis of 1-arylpropan-2-ones under aerobic conditions. Reaction Chemistry & Engineering 2021, 6, 1796–1800. doi:10.1039/d1re00297j
• Giofrè, S. V.; Tiecco, M.; Ferlazzo, A.; Romeo, R.; Ciancaleoni, G.; Germani, R.; Iannazzo, D. Base-Free Copper-Catalyzed Azide-Alkyne Click Cycloadditions (CuAAc) in Natural Deep Eutectic Solvents as Green and Catalytic Reaction Media**. European Journal of Organic Chemistry 2021, 2021, 4777–4789. doi:10.1002/ejoc.202100698
• Tiuftiakov, N. Y.; Strelnikova, J. O.; Filippov, I. P.; Khaidarov, A. R.; Khlebnikov, A. F.; Bunev, A. S.; Novikov, M. S.; Rostovskii, N. V. Rhodium-Catalyzed Synthesis of 2-Aroylpyrimidines via Cascade Heteropolyene Rearrangement. Organic letters 2021, 23, 6998–7002. doi:10.1021/acs.orglett.1c02706
• Ríos-Lombardía, N.; Cicco, L.; Yamamoto, K.; Hernández-Fernández, J. A.; Morís, F.; Capriati, V.; García-Álvarez, J.; González-Sabín, J. Deep eutectic solvent-catalyzed Meyer-Schuster rearrangement of propargylic alcohols under mild and bench reaction conditions. Chemical communications (Cambridge, England) 2020, 56, 15165–15168. doi:10.1039/d0cc06584f

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