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Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N‑acetylamino malonic acid monoesters

Olesja Koleda, Janis Sadauskis, Darja Antonenko, Edvards Janis Treijs, Raivis Davis Steberis and Edgars Suna

Beilstein J. Org. Chem. 2025, 21, 630–638. https://doi.org/10.3762/bjoc.21.50

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Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N‑acetylamino malonic acid monoesters

Olesja Koleda, Janis Sadauskis, Darja Antonenko, Edvards Janis Treijs, Raivis Davis Steberis and Edgars Suna

Beilstein J. Org. Chem. 2025, 21, 630–638. https://doi.org/10.3762/bjoc.21.50

How to Cite

Koleda, O.; Sadauskis, J.; Antonenko, D.; Treijs, E. J.; Steberis, R. D.; Suna, E. Beilstein J. Org. Chem. 2025, 21, 630–638. doi:10.3762/bjoc.21.50

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TY  - JOUR
A1  - Koleda, Olesja
A1  - Sadauskis, Janis
A1  - Antonenko, Darja
A1  - Treijs, Edvards Janis
A1  - Steberis, Raivis Davis
A1  - Suna, Edgars
T1  - Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N‑acetylamino malonic acid monoesters
JF  - Beilstein Journal of Organic Chemistry
PY  - 2025///
VL  - 21
SP  - 630
EP  - 638
SN  - 1860-5397
DO  - 10.3762/bjoc.21.50
PB  - Beilstein-Institut
JA  - Beilstein J. Org. Chem.
UR  - https://doi.org/10.3762/bjoc.21.50
KW  - anodic oxidation
KW  - decarboxylation
KW  - electrosynthesis
KW  - Hofer–Moest reaction
KW  - non-proteinogenic amino acids
N2  - The electrochemical synthesis of 2-aminoprolines based on anodic decarboxylation–intramolecular amidation of readily available N-acetylamino malonic acid monoesters is reported. The decarboxylative amidation under Hofer–Moest reaction conditions proceeds in an undivided cell under constant current conditions in aqueous acetonitrile and provides access to N-sulfonyl, N-benzoyl, and N-Boc-protected 2-aminoproline derivatives.
ER  -

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aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)