Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold

Scholarly Works

• Janicka, M.; Sztanke, M.; Sztanke, K. Modeling the Blood-Brain Barrier Permeability of Potential Heterocyclic Drugs via Biomimetic IAM Chromatography Technique Combined with QSAR Methodology. Molecules (Basel, Switzerland) 2024, 29, 287. doi:10.3390/molecules29020287
• Tshiluka, N. R.; Bvumbi, M. V.; Tshishonga, U.; Mnyakeni-Moleele, S. S. Synthesis of new 5-benzylidene-hydantoin esters. Journal of Chemical Research 2022, 46, 174751982211041. doi:10.1177/17475198221104183
• Tzvetkov, N. T.; Peeva, M. I.; Tsakovska, I.; Milella, L.; Pajeva, I.; Stammler, H.-G. The crystal structure of (4SR)-7-(3,4-dichlorobenzyl)-4,8,8-trimethyl-7,8-dihydroimidazo[5,1c][1,2,4]triazine-3,6(2H,4H)-dione, C15H16Cl2N4O2. Zeitschrift für Kristallographie - New Crystal Structures 2022, 237, 319–321. doi:10.1515/ncrs-2022-0016
• David, O. R. Comprehensive Heterocyclic Chemistry IV - Bicyclic 5-6 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: Three Extra Heteroatoms 1:2. Comprehensive Heterocyclic Chemistry IV; Elsevier, 2022; pp 755–779. doi:10.1016/b978-0-12-818655-8.00058-5
• Ivanov, S. M. Comprehensive Heterocyclic Chemistry IV - 1,2,4-Triazines and Their Benzo Derivatives. Comprehensive Heterocyclic Chemistry IV; Elsevier, 2022; pp 29–180. doi:10.1016/b978-0-12-818655-8.00062-7
• Fetzer, C.; Korotkov, V. S.; Sieber, S. A. Hydantoin analogs inhibit the fully assembled ClpXP protease without affecting the individual peptidase and chaperone domains. Organic & biomolecular chemistry 2019, 17, 7124–7127. doi:10.1039/c9ob01339c
• Giannakopoulou, E.; Pardali, V.; Skrettas, I.; Zoidis, G. Transesterification instead of N-Alkylation: An Intriguing Reaction. ChemistrySelect 2019, 4, 3195–3198. doi:10.1002/slct.201900263
• Konnert, L.; Lamaty, F.; Martinez, J.; Colacino, E. Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold. Chemical reviews 2017, 117, 13757–13809. doi:10.1021/acs.chemrev.7b00067
• Tzvetkov, N. T.; Neumann, B.; Stammler, H.-G. The twinned crystal structure of (4SR)-7-benzyl-2, 4,8,8-tetramethyl-7,8-dihydroimidazo[5,1-c] [1,2,4] triazine-3,6( 2H, 4H)-dione, C16H20N4O2. Zeitschrift für Kristallographie - New Crystal Structures 2017, 232, 231–233. doi:10.1515/ncrs-2016-0218
• Konnert, L.; Gonnet, L.; Halasz, I.; Suppo, J.-S.; de Figueiredo, R. M.; Campagne, J.-M.; Lamaty, F.; Martinez, J.; Colacino, E. Mechanochemical Preparation of 3,5-Disubstituted Hydantoins from Dipeptides and Unsymmetrical Ureas of Amino Acid Derivatives. The Journal of organic chemistry 2016, 81, 9802–9809. doi:10.1021/acs.joc.6b01832
• Tzvetkov, N. T.; Neumann, B.; Stammler, H.-G.; Antonov, L. A simple approach to multifunctionalized N1-alkylated 7-amino-6-azaoxindole derivatives using their in situ stabilized tautomer form. Tetrahedron 2016, 72, 6455–6466. doi:10.1016/j.tet.2016.08.055
• Ghorbani-Vaghei, R.; Shahriari, A.; Salimi, Z.; Hajinazari, S. Solvent-free synthesis of triazines using N-halosulfonamides. RSC Advances 2015, 5, 3665–3669. doi:10.1039/c4ra10892b
• Tzvetkov, N. T.; Hinz, S.; Küppers, P.; Gastreich, M.; Müller, C. E. Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency. Journal of medicinal chemistry 2014, 57, 6679–6703. doi:10.1021/jm500729a

Explore citations to this article at