Total synthesis of ochnaflavone

Scholarly Works

• Patel, K.; Patel, D. K. Therapeutic Potential and Pharmacological Activities of Bioflavonoid 'Ochnaflavone' in Medicine: Diverse Scaffolds and Promise Leads for Drug Discovery. Anti-Infective Agents 2024, 22. doi:10.2174/0122113525284912240221115753
• Osorio-Olivares, M. E.; Vásquez-Martínez, Y.; Díaz, K.; Canelo, J.; Taborga, L.; Espinoza-Catalán, L. Antibacterial and Antioxidant Activity of Synthetic Polyoxygenated Flavonoids. International journal of molecular sciences 2024, 25, 5999. doi:10.3390/ijms25115999
• Lin, S.; Ganesan, A. R.; Vargas‐De‐La‐Cruz, C.; Ortiz‐Viedma, J.; Xiao, J. Advances in resources, biosynthesis pathway, bioavailability, bioactivity, and pharmacology of ochnaflavone. Future Postharvest and Food 2024, 1, 47–60. doi:10.1002/fpf2.12011
• Ren, M.; Li, S.; Gao, Q.; Qiao, L.; Cao, Q.; Yang, Z.; Chen, C.; Jiang, Y.; Wang, G.; Fu, S. Advances in the Anti-Tumor Activity of Biflavonoids in Selaginella. International journal of molecular sciences 2023, 24, 7731. doi:10.3390/ijms24097731
• Zhang, Y.-N.; Zhu, G.-H.; Liu, W.; Xiong, Y.; Hu, Q.; Zhuang, X.-Y.; Jia, G.-H.; Zhang, W.-D.; Ge, G.-B. Discovery and characterization of the covalent SARS-CoV-2 3CLpro inhibitors from Ginkgo biloba extract via integrating chemoproteomic and biochemical approaches. Phytomedicine : international journal of phytotherapy and phytopharmacology 2023, 114, 154796. doi:10.1016/j.phymed.2023.154796
• Yang, X.; Lim, S. H. M.; Lin, J.; Wu, J.; Tang, H.; Zhao, F.; Liu, F.; Sun, C.; Shi, X.; Kuang, Y.; Toy, J. Y. H.; Du, K.; Zhang, Y.; Wang, X.; Sun, M.; Song, Z.; Wang, T.; Wu, J.; Houk, K. N.; Huang, D. Oxygen mediated oxidative couplings of flavones in alkaline water. Nature communications 2022, 13, 6424. doi:10.1038/s41467-022-34123-w
• Gorai, D.; Jash, S. K.; Kundu, D. Progress in the Research of Naturally Occurring Biflavonoids: A Look Through. Frontiers in Natural Product Chemistry: Volume 10; BENTHAM SCIENCE PUBLISHERS, 2022; pp 73–153. doi:10.2174/9789815040760122100005
• Li, C.-Y.; Wang, H.-N.; He, R.-J.; Huang, J.; Song, L.-L.; Song, Y.-Q.; Huo, P.-C.; Hou, J.; Ji, G.; Ge, G.-B. Discovery and characterization of amentoflavone as a naturally occurring inhibitor against the bile salt hydrolase produced by Lactobacillus salivarius. Food & function 2022, 13, 3318–3328. doi:10.1039/d1fo03277a
• He, X.; Yang, F.; Huang, X.-A. Proceedings of Chemistry, Pharmacology, Pharmacokinetics and Synthesis of Biflavonoids. Molecules (Basel, Switzerland) 2021, 26, 6088. doi:10.3390/molecules26196088
• Song, Y.-Q.; He, R.-J.; Pu, D.; Guan, X.-Q.; Shi, J.-H.; Li, Y.-G.; Hou, J.; Jia, S.-N.; Qin, W.-W.; Fang, S.-Q.; Ge, G.-B. Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2. Frontiers in pharmacology 2021, 12, 655659. doi:10.3389/fphar.2021.655659
• Egbujor, M. C.; Saha, S.; Buttari, B.; Profumo, E.; Saso, L. Activation of Nrf2 signaling pathway by natural and synthetic chalcones: a therapeutic road map for oxidative stress. Expert review of clinical pharmacology 2021, 14, 465–480. doi:10.1080/17512433.2021.1901578
• Menezes, J. C.; Diederich, M. Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies. Pharmacological research 2021, 167, 105525. doi:10.1016/j.phrs.2021.105525
• Valdés, E.; González, C.; Díaz, K.; Vásquez-Martínez, Y.; Mascayano, C.; Torrent, C.; Cabezas, F.; Mejias, S.; Montoya, M.; Martín, M. C.-S.; Muñoz, M. A.; Joseph-Nathan, P.; Osorio, M.; Taborga, L. Biological Properties and Absolute Configuration of Flavanones From Calceolariathyrsiflora Graham. Frontiers in pharmacology 2020, 11, 1125. doi:10.3389/fphar.2020.01125
• Chen, T.-R.; Wei, L.-H.; Guan, X.-Q.; Huang, C.; Liu, Z.; Wang, F.; Hou, J.; Jin, Q.; Yifan, L.; Peihao, W.; Zhang, S.; Ge, G.-B.; Guo, W. Biflavones from Ginkgo biloba as inhibitors of human thrombin. Bioorganic chemistry 2019, 92, 103199. doi:10.1016/j.bioorg.2019.103199
• bin Break, M. K.; Hossan, S.; Khoo, Y.; Qazzaz, M. E.; Al-Hayali, M.; Chow, S. C.; Wiart, C.; Bradshaw, T. D.; Collins, H. M.; Khoo, T.-J. Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway. Fitoterapia 2018, 125, 161–173. doi:10.1016/j.fitote.2018.01.006
• Njock, G. B. B.; Grougnet, R.; Efstathiou, A.; Smirlis, D.; Genta-Jouve, G.; Michel, S.; Mbing, J. N.; Kritsanida, M. A Nitrile Glucoside and Biflavones from the Leaves of Campylospermum excavatum (Ochnaceae). Chemistry & biodiversity 2017, 14. doi:10.1002/cbdv.201700241
• Jackowski, J.; Popłoński, J.; Twardowska, K.; Magiera-Dulewicz, J.; Hurej, M.; Huszcza, E. Deterrent activity of hops flavonoids and their derivatives against stored product pests. Bulletin of entomological research 2017, 107, 592–597. doi:10.1017/s0007485317000050
• Ismail, A. M.; Musa, A. M.; Nasir, T.; Magaji, M. G.; Jega, Y. A.; Ibrahim, I. Anti-proliferative study and isolation of Ochnaflavone from the ethyl acetate-soluble fraction of Ochna kibbiensis Hutch & Dalziel. Natural product research 2016, 31, 2149–2152. doi:10.1080/14786419.2016.1274892
• Tong, D.; Duan, H.; Wang, J.; Yang, Z.; Lin, Y. Aggregation-enhanced excimer emission (AEEE) based on pyrenylchalcone and 2-to-4 molecular decoder by biothiols and polyanions in aqueous media. Sensors and Actuators B: Chemical 2014, 195, 80–84. doi:10.1016/j.snb.2014.01.003

Explore citations to this article at