Supporting Information
| Supporting Information File 1: Synthetic procedures and 1H and 13C NMR spectra of all new compounds; HMQC and HMBC spectra from Figure 5; supporting Figure S1 and Table S1. | ||
| Format: PDF | Size: 2.7 MB | Download |
| Supporting Information File 2: 1H and 13C NMR spectra of all new compounds in jcamp-dx format. | ||
| Format: ZIP | Size: 2.0 MB | Download |
| Supporting Information File 3: X-ray crystal structure of 2. | ||
| Format: CIF | Size: 39.0 KB | Download |
| Supporting Information File 4: Structure factors for 2. | ||
| Format: HKL | Size: 387.8 KB | Download |
Cite the Following Article
Studies toward bivalent κ opioids derived from salvinorin A: heteromethylation of the furan ring reduces affinity
Thomas A. Munro, Wei Xu, Douglas M. Ho, Lee-Yuan Liu-Chen and Bruce M. Cohen
Beilstein J. Org. Chem. 2013, 9, 2916–2924.
https://doi.org/10.3762/bjoc.9.328
How to Cite
Munro, T. A.; Xu, W.; Ho, D. M.; Liu-Chen, L.-Y.; Cohen, B. M. Beilstein J. Org. Chem. 2013, 9, 2916–2924. doi:10.3762/bjoc.9.328
Download Citation
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window
below.
Citation data in RIS format can be imported by all major citation management software, including EndNote,
ProCite, RefWorks, and Zotero.
Citations to This Article
Up to 20 of the most recent references are displayed here.
Scholarly Works
- Zha, J.; He, J.; Wu, C.; Zhang, M.; Liu, X.; Zhang, J. Designing drugs and chemical probes with the dualsteric approach. Chemical Society reviews 2023, 52, 8651–8677. doi:10.1039/d3cs00650f
- Root-Bernstein, R. Biased, Bitopic, Opioid-Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction. Pharmaceuticals (Basel, Switzerland) 2022, 15, 214. doi:10.3390/ph15020214
- Salem, M. A.; Zayed, A.; Ezzat, S. M. Psychoactive plants and phytochemicals. Phytochemistry, the Military and Health; Elsevier, 2021; pp 121–150. doi:10.1016/b978-0-12-821556-2.00028-1
- Feng, L. Y.; Battulga, A.; Han, E.; Chung, H.; Li, J.-H. New psychoactive substances of natural origin: A brief review. Journal of food and drug analysis 2017, 25, 461–471. doi:10.1016/j.jfda.2017.04.001
- Phipps, S. M.; Grundmann, O. Pharmacology and Structure-Activity Relationship of Natural Products With Psychoactive Effects From Salvia divinorum, Mitragyna speciosa, and Ayahuasca. Studies in Natural Products Chemistry 2017, 53, 1–44. doi:10.1016/b978-0-444-63930-1.00001-6
- Maillet, E.; Milon, N.; Heghinian, M. D.; Fishback, J. A.; Schürer, S. C.; Garamszegi, N.; Mash, D. C. Noribogaine is a G-protein biased κ-opioid receptor agonist. Neuropharmacology 2015, 99, 675–688. doi:10.1016/j.neuropharm.2015.08.032
- Guerrieri, E.; Mallareddy, J. R.; Tóth, G.; Schmidhammer, H.; Spetea, M. Synthesis and Pharmacological Evaluation of [3H]HS665, a Novel, Highly Selective Radioligand for the Kappa Opioid Receptor. ACS chemical neuroscience 2014, 6, 456–463. doi:10.1021/cn5002792
- Riley, A. P.; Groer, C. E.; Young, D.; Ewald, A.; Kivell, B. M.; Prisinzano, T. E. Synthesis and κ-Opioid Receptor Activity of Furan-Substituted Salvinorin A Analogues. Journal of medicinal chemistry 2014, 57, 10464–10475. doi:10.1021/jm501521d
- Bodnar, R. J. Endogenous opiates and behavior: 2013. Peptides 2014, 62, 67–136. doi:10.1016/j.peptides.2014.09.013
Patents
- AUSTIN JOEL FRANCIS; VANHEYST MICHAEL DAVID; HARVEY JAMES S; ROWLEY ELIZABETH GERIG; LAMARQUE-LACOSTE CHRISTOPHE. Allosteric modulators of the mu opioid receptor. US 11071731 B2, July 27, 2021.
- AUSTIN JOEL FRANCIS; VANHEYST MICHAEL DAVID; HARVEY JAMES S; ROWLEY ELIZABETH GERIG; LAMARQUE-LACOSTE CHRISTOPHE. Allosteric modulators of the mu opioid receptor. US 10603313 B2, March 31, 2020.
