Supporting Information
Supporting Information File 1: 1D and 2D NMR spectra for 2 and d4-2 and all details for the NMR stability study of GHB glucuronide 2. | ||
Format: PDF | Size: 1.9 MB | Download |
Cite the Following Article
Synthesis and stability study of a new major metabolite of γ-hydroxybutyric acid
Ida Nymann Petersen, Jesper Langgaard Kristensen, Christian Tortzen, Torben Breindahl and Daniel Sejer Pedersen
Beilstein J. Org. Chem. 2013, 9, 641–646.
https://doi.org/10.3762/bjoc.9.72
How to Cite
Nymann Petersen, I.; Langgaard Kristensen, J.; Tortzen, C.; Breindahl, T.; Sejer Pedersen, D. Beilstein J. Org. Chem. 2013, 9, 641–646. doi:10.3762/bjoc.9.72
Download Citation
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window
below.
Citation data in RIS format can be imported by all major citation management software, including EndNote,
ProCite, RefWorks, and Zotero.
Citations to This Article
Up to 20 of the most recent references are displayed here.
Scholarly Works
- Son, S. U.; Jang, S.; Kang, B.; Kim, J.-S.; Lim, J.; Seo, S.; Kang, T.; Jung, J.; Lee, K.-S.; Kim, H.; Lim, E. K. Colorimetric paper sensor for visual detection of date-rape drug γ-hydroxybutyric acid (GHB). Sensors and Actuators B: Chemical 2021, 347, 130598. doi:10.1016/j.snb.2021.130598
- Jarsiah, P.; Kueting, T.; Roehrich, J.; Germerott, T.; Remane, D.; Toennes, S. W.; Scholtis, S.; Krumbiegel, F.; Hess, C. GHB related acids (dihydroxy butyric acids, glycolic acid) can help in the interpretation of post mortem GHB results. Forensic science international 2020, 316, 110536. doi:10.1016/j.forsciint.2020.110536
- Pedersen, D. S.; Bélanger, P.; Frykman, M.; Andreasen, K.; Goudreault, D.; Pedersen, H.; Hindersson, P.; Breindahl, T. Ethylene glycol: Evidence of glucuronidation in vivo shown by analysis of clinical toxicology samples. Drug testing and analysis 2019, 11, 1094–1108. doi:10.1002/dta.2584
- Busardò, F. P.; Gottardi, M.; Tini, A.; Mortali, C.; Giorgetti, R.; Pichini, S. Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry Assay for Determination of Endogenous GHB and GHB-Glucuronide in Nails. Molecules (Basel, Switzerland) 2018, 23, 2686. doi:10.3390/molecules23102686
- Piper, T.; Mehling, L.-M.; Spottke, A.; Heidbreder, A.; Young, P.; Madea, B.; Hess, C.; Schänzer, W.; Thevis, M. Potential of GHB phase-II-metabolites to complement current approaches in GHB post administration detection. Forensic science international 2017, 279, 157–164. doi:10.1016/j.forsciint.2017.08.023
- Busardò, F. P.; Pichini, S.; Zaami, S.; Pacifici, R.; Kintz, P. Hair testing of GHB: an everlasting issue in forensic toxicology. Clinical chemistry and laboratory medicine 2017, 56, 198–208. doi:10.1515/cclm-2017-0397
- Mehling, L.-M.; Wang, X.; Johansen, S.-S.; Spottke, A.; Heidbreder, A.; Young, P.; Madea, B.; Hess, C. Determination of GHB and GHB-β-O-glucuronide in hair of three narcoleptic patients-Comparison between single and chronic GHB exposure. Forensic science international 2017, 278, e8–e13. doi:10.1016/j.forsciint.2017.07.027
- Mehling, L.-M.; Piper, T.; Spottke, A.; Heidbreder, A.; Young, P.; Madea, B.; Thevis, M.; Hess, C. GHB-O-β-glucuronide in blood and urine is not a suitable tool for the extension of the detection window after GHB intake. Forensic Toxicology 2017, 35, 263–274. doi:10.1007/s11419-016-0352-7
- Busardò, F. P.; Kyriakou, C.; Marchei, E.; Pacifici, R.; Pedersen, D. S.; Pichini, S. Ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) for determination of GHB, precursors and metabolites in different specimens: Application to clinical and forensic cases. Journal of pharmaceutical and biomedical analysis 2017, 137, 123–131. doi:10.1016/j.jpba.2017.01.022
- Mehling, L.-M.; Piper, T.; Dib, J.; Pedersen, D. S.; Madea, B.; Hess, C.; Thevis, M. Development and validation of a HPLC–QTOF-MS method for the determination of GHB-β- O -glucuronide and GHB-4-sulfate in plasma and urine. Forensic Toxicology 2016, 35, 77–85. doi:10.1007/s11419-016-0339-4
- Wang, X.; Linnet, K.; Johansen, S. S. Development of a UPLC–MS/MS method for determining γ-hydroxybutyric acid (GHB) and GHB glucuronide concentrations in hair and application to forensic cases. Forensic Toxicology 2015, 34, 51–60. doi:10.1007/s11419-015-0285-6
- Petersen, I. N.; Tortzen, C.; Kristensen, J. L.; Pedersen, D. S.; Breindahl, T. Identification of a New Metabolite of GHB: Gamma-Hydroxybutyric Acid Glucuronide. Journal of analytical toxicology 2013, 37, 291–297. doi:10.1093/jat/bkt027
Patents
- LOURENÇO EVA CORREIA; ASCENSO OSVALDO. Neutral glycosylated amides and dianionic glucuronidated acids as stabilizers for biological molecules. US 12098162 B2, Sept 24, 2024.