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Beilstein J. Org. Chem. 2024, 20, 3182–3190, doi:10.3762/bjoc.20.263
Graphical Abstract
Figure 1: Representative examples of fluorine containing, biologically active compounds.
Scheme 1: Strategies for the synthesis of α-alkyl sulfoxonium ylides.
Scheme 2: Exploring substrate scope in the direct α-fluoroalkylation of sulfoxonium ylides.
Scheme 3: Synthetic applications of fluoroalkylated sulfoxonium ylides.
Figure 2: Possible mechanisms for the reaction of 1a and 2a leading to 3a (via B), proceeding via either halo...
Figure 3: Electrostatic potential of 2a’ from 0.075 e to 0.21 e, showing two sigma holes of potentials 0.20 a...
Figure 4: The optimized reaction coordinate diagrams for the halogen bond-mediated mechanism (path 1, left) a...