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Beilstein J. Org. Chem. 2024, 20, 1029–1036, doi:10.3762/bjoc.20.91
Graphical Abstract
Figure 1: Structure of HeE1-2Tyr (1) and of the derivatives synthesized in this work.
Scheme 1: Synthetic pathway to benzoxazole analogue 2 of HeE1-2Tyr (1). Reagents and conditions: a) TMSN3, Tf...
Scheme 2: Synthetic pathway to pyridone derivatives 3a–c of HeE1-2Tyr (1). Reagents and conditions: a) MeI, K2...
Scheme 3: Synthetic pathway to thiazolopyridone derivatives 4a,b of HeE1-2Tyr (1). Reagents and conditions: a...
Figure 2: Analysis of inhibitory activity against SARS-CoV-2 RdRp using primer extension assay. A) Gel-based ...