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Beilstein J. Org. Chem. 2024, 20, 2592–2598, doi:10.3762/bjoc.20.218
Graphical Abstract
Figure 1: Aminoquinazolines and our new target molecules.
Scheme 1: Synthesis of the desired targets 4.
Figure 2: Target molecules 4 prepared with the yields for the last step.
Beilstein J. Org. Chem. 2017, 13, 2115–2121, doi:10.3762/bjoc.13.208
Figure 1: Representative examples of bioactive imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, imidazopyr...
Scheme 1: Retrosynthetic scheme for the preparation of our target molecules A.
Scheme 2: Synthesis of enones 6 with a gem-difluoroalkyl side chain.
Scheme 3: Synthesis of 7a.
Figure 2: Structures of 7a and 7e by X-ray crystallography analysis.
Scheme 4: One-pot synthesis of 7a.
Beilstein J. Org. Chem. 2013, 9, 1943–1948, doi:10.3762/bjoc.9.230
Scheme 1: Strategy towards the target molecules.
Scheme 2: Synthesis of enones with a gem-difluoroalkyl side chain.
Scheme 3: Synthesis of pyrazolines with a gem-difluoro side chain.
Scheme 4: One-pot synthesis of pyrazolines with a gem-difluoro side chain.
Scheme 5: Synthesis of pyrrolines with a gem-difluoro alkyl side chain.
Scheme 6: One-pot synthesis of pyrrolines with a gem-difluoro side chain.
Scheme 7: Pd-catalyzed coupling reactions towards chemical libraries of pyrazolines with a gem-difluoro side ...
Scheme 8: Pd-catalyzed coupling reactions towards chemical libraries of pyrrolines with a gem-difluoro side c...