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Beilstein J. Org. Chem. 2024, 20, 2827–2833, doi:10.3762/bjoc.20.238
Graphical Abstract
Scheme 1: Synthesis of polyfunctionalized methane derivatives through successive nucleophilic additions to th...
Scheme 2: Cyclization of 4a quenched by D2O.
Scheme 3: Plausible mechanisms for the ring closure of 4.
Scheme 4: Hydration of the ethynyl group of 4a.
Beilstein J. Org. Chem. 2023, 19, 892–900, doi:10.3762/bjoc.19.67
Scheme 1: Versatile reactivities of cyclopropanes 1a.
Scheme 2: Preparative methods for cyclopropanedicarboxylates 1a.
Scheme 3: Bromination of ethyl acetoacetate (3c) and reaction with nitrostyrene 2a.
Scheme 4: Reaction of 4b with (diacetoxyiodo)benzene (top); structural determination of product 9 (bottom).
Figure 1: Monitoring the cyclization reaction using 4e by 1H NMR.
Scheme 5: A plausible mechanism for formation of cyclopropane 1 and dihydrofuran 8.
Scheme 6: Tin(II)-mediated ring expansion of nitrocyclopropane 1e.