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Beilstein J. Org. Chem. 2024, 20, 2946–2953, doi:10.3762/bjoc.20.247
Graphical Abstract
Scheme 1: Generation of gem-difluorovinyl and trifluorovinyl Michael acceptors and their use in the synthesis...
Scheme 2: Formation of α,β-difluorinated and α-fluorinated α,β-unsaturated amides.
Scheme 3: Formation of β-fluorinated and nonfluorinated α,β-unsaturated amides.
Scheme 4: Michael addition of 1a–d with tert-BuLi.
Scheme 5: Michael addition of 2a–d with tert-BuLi.
Scheme 6: Formation of N-methylation products.